1.
Bioorg Med Chem Lett
; 16(10): 2800-3, 2006 May 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16497499
RESUMEN
A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [(125)I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.