1.
Org Lett
; 5(23): 4249-51, 2003 Nov 13.
Artículo
en Inglés
| MEDLINE
| ID: mdl-14601972
RESUMEN
[structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.
2.
Bioorg Med Chem Lett
; 12(17): 2355-8, 2002 Sep 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12161132
RESUMEN
By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. This SAR study led to the identification of a benzimidazolinone series of compounds which display single digit nanomolar NK(1)/NK(2) affinity and near micromolar binding for the NK(3) receptor.