RESUMEN
Complex clinical, functional an laboratory examination of children living under unacceptable risk conditions due to aerogenous exposure to cadmium, chromium, lead and phenol revealed that kidney diseases associated with exposure to metals and phenol develop in children with genetic predisposition to disordered biotransformation of chemicals--polymorphism of genes CYPOX, RCYT 450, SULTA1 in homozygous and heterozygous variants. Increased levels of chemicals in blood causes microcirculation disorders in renal cortex, direct toxic effect in nephrons, suppresses activity of anitoxidant defense on cellular and systemic levels. The authors specified pathogenetically based complex of clinical and laboratory diagnostic markers of chronic kidney diseases associated with exposure to metals (cadmium, chromium, lead) and oxygen-containing (phenol) organic compounds.
Asunto(s)
Contaminantes Atmosféricos/toxicidad , Exposición a Riesgos Ambientales/análisis , Glomerulonefritis/diagnóstico , Metales Pesados/toxicidad , Nefritis Intersticial/diagnóstico , Fenol/toxicidad , Adolescente , Contaminantes Atmosféricos/sangre , Biomarcadores/análisis , Biotransformación/genética , Niño , Preescolar , Exposición a Riesgos Ambientales/efectos adversos , Glomerulonefritis/inducido químicamente , Glomerulonefritis/epidemiología , Glomerulonefritis/genética , Humanos , Industrias , Metales Pesados/sangre , Nefritis Intersticial/inducido químicamente , Nefritis Intersticial/epidemiología , Nefritis Intersticial/genética , Fenol/sangre , Federación de RusiaRESUMEN
There are presented directions of the improvement of strategic approaches to the prevention of respiratory diseases associated with exposure to chemical environmental factors in children. There were substantiated principles of construction of health-preventive technologies, target groups, hygienic and clinical criteria for their formation, volumes and forms of implementation, targeted indices of efficacy.
Asunto(s)
Contaminantes Atmosféricos/efectos adversos , Exposición a Riesgos Ambientales/efectos adversos , Guías como Asunto/normas , Sustancias Peligrosas/efectos adversos , Servicios Preventivos de Salud/organización & administración , Trastornos Respiratorios/prevención & control , Niño , Humanos , Trastornos Respiratorios/inducido químicamenteRESUMEN
303 children with the diagnosis "Hepatobiliary disorders of cystic duct or gall bladder" and "Sphincter Oddu's spasm" have been examined. After a profound children's examination, the data of objective survey, and also laboratory, biochemical, immune, functional rates (such as ultrasound survey, cardiointervalography) and findings of chemical-analytical survey of the toxics rate (such as aroma carbons, phenol, aldehydes, aliphatic alcohols) in biospheres of children's organisms were a nalysed. The evaluation of the effectiveness of children's hepatobilliary disorders'treatment in conditions of the environmentae negative factors' influence.