Detalles de la búsqueda
1.
Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure.
J Proteome Res;
22(4): 1116-1126, 2023 04 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36977373
2.
Determination of Degradation Kinetics and Effect of Anion Exchange Resin on Dissolution of Novel Anticancer Drug Rigosertib in Acidic Conditions.
AAPS PharmSciTech;
19(1): 93-100, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28600665
3.
Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy.
Hematol Oncol;
33(2): 57-66, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24777753
4.
Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad.
Sci Rep;
14(1): 4518, 2024 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38402257
5.
Phase I clinical trial of oral rigosertib in patients with myelodysplastic syndromes.
Br J Haematol;
162(4): 517-24, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23789936
6.
Effects of formulation and route of administration on the systemic availability of Ex-RAD®, a new radioprotectant, in preclinical species.
Biopharm Drug Dispos;
32(2): 99-111, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21341279
7.
Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure.
Sci Rep;
11(1): 11449, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34075191
8.
Rigosertib in combination with azacitidine in patients with myelodysplastic syndromes or acute myeloid leukemia: Results of a phase 1 study.
Leuk Res;
94: 106369, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32442785
9.
Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms.
Radiat Res;
171(2): 173-9, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19267542
10.
Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats.
Eur J Drug Metab Pharmacokinet;
44(4): 531-538, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-30701428
11.
Development and validation of a sensitive liquid chromatographic method for the analysis of a novel radioprotectant: ON 01210.Na.
J Pharm Biomed Anal;
43(5): 1796-803, 2007 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17184951
12.
Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies.
Clin Cancer Res;
20(6): 1656-65, 2014 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24493827
13.
Determination of intestinal permeability of rigosertib (ON 01910.Na, Estybon): correlation with systemic exposure.
J Pharm Pharmacol;
65(7): 960-9, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23738723
14.
Disposition of ON 01210.Na (Ex-RAD(R)), a novel radioprotectant, in the isolated perfused rat liver: probing metabolic inhibition to increase systemic exposure.
J Pharm Sci;
102(2): 732-40, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23212688
15.
Phase 1 study of intravenous rigosertib (ON 01910.Na), a novel benzyl styryl sulfone structure producing G2/M arrest and apoptosis, in adult patients with advanced cancer.
Am J Cancer Res;
3(3): 323-38, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23841031
16.
Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response.
Radiat Oncol;
7: 6, 2012 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22264334
17.
Radioprotective effects of ON 01210.Na upon oral administration.
J Radiat Res;
53(3): 368-76, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22739006
18.
Phase I study of Rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and Polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer.
Clin Cancer Res;
18(7): 2048-55, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22338014
19.
Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice.
J Radiat Res;
53(4): 526-36, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22843617
20.
Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na.
Leuk Res;
36(8): 982-9, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22524974