Venous wall graft in the eyelid reconstruction: observations drawn from 64 cases.

The aim of this report is to illustrate the venous wall graft and to present the observations drawn from a large series of eyelid reconstructions performed with this method. Sixty-four patients underwent venous wall grafts, mostly after resection of invasive carcinomas of the eyelids and, in only one case, after traumatic injury. All patients had good functional and cosmetic results. The average follow-up time was 6.5 years. Few negligible complications were observed. Only two cases (3.1%) needed further surgical treatment. Vein graft is a reliable alternative to traditional procedures in replacing tarsus-conjunctival layer, achieving satisfactory results. A single surgical session is required, usually without complications.

Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial.

As lactoferrin is a nutritional supplement with proven antiviral and immunomodulatory abilities, it may be used to improve the clinical course of COVID-19. The clinical efficacy and safety of bovine lactoferrin were evaluated in the LAC randomized double-blind placebo-controlled trial. A total of 218 hospitalized adult patients with moderate-to-severe COVID-19 were randomized to receive 800 mg/die oral bovine lactoferrin (n = 113) or placebo (n = 105), both given in combination with standard COVID-19 therapy. No differences in lactoferrin vs. placebo were observed in the primary outcomes: the proportion of death or intensive care unit admission (risk ratio of 1.06 (95% CI 0.63-1.79)) or proportion of discharge or National Early Warning Score 2 (NEWS2) ≤ 2 within 14 days from enrollment (RR of 0.85 (95% CI 0.70-1.04)). Lactoferrin showed an excellent safety and tolerability profile. Even though bovine lactoferrin is safe and tolerable, our results do not support its use in hospitalized patients with moderate-to-severe COVID-19.

Reconstruction of the tarsus-conjunctival layer using a venous wall graft.

PURPOSE: The repair of full-thickness defects of the eyelids poses a challenge, because the reconstruction of the tarsus-conjunctival layer often results in aesthetically and functionally unsatisfactory outcomes. The authors' aim was to create a new method to repair large tarsus-conjunctival losses and to examine the outcomes of its use. METHODS: Seven patients with invasive carcinoma of the eyelids underwent a venous wall graft. RESULTS: All patients had good to outstanding results and no complications. CONCLUSION: This new reconstruction of the deeper layer of the eyelid provides a useful alternative to traditional methods (composite grafts and full-thickness flaps). Our new surgical technique is easy to execute and has good functional and aesthetic results.