Detalles de la búsqueda
1.
A novel semi-mechanistic tumor growth fraction model for translation of preclinical efficacy of anti-glypican 3 antibody drug conjugate to human.
Biopharm Drug Dispos;
41(8-9): 319-333, 2020 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-32678919
2.
Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
J Pharmacol Exp Ther;
368(1): 136-145, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30361237
3.
Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.
Drug Metab Dispos;
47(11): 1352-1360, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31427432
4.
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Mol Pharm;
16(9): 4065-4076, 2019 09 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31335150
5.
Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.
Mol Pharm;
16(6): 2342-2353, 2019 06 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31039308
6.
Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Drug Metab Dispos;
46(2): 178-188, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29162614
7.
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.
Drug Metab Dispos;
45(8): 908-919, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28576766
8.
Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.
J Pharmacol Exp Ther;
357(2): 382-93, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26907622
9.
Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.
J Pharmacol Exp Ther;
358(3): 397-404, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27317801
10.
Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.
Drug Metab Dispos;
44(2): 238-49, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26608080
11.
Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.
Drug Metab Dispos;
44(3): 320-8, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26714763
12.
Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.
Mol Pharm;
13(4): 1206-16, 2016 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26910619
13.
Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans.
Biopharm Drug Dispos;
37(2): 93-106, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25869904
14.
Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.
J Pharmacol Exp Ther;
353(2): 380-91, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25740896
15.
Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.
J Pharmacol Exp Ther;
355(3): 506-15, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26442523
16.
Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
Drug Metab Dispos;
43(7): 984-93, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25904762
17.
Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.
Drug Metab Dispos;
43(11): 1788-94, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26341276
18.
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.
Biopharm Drug Dispos;
36(6): 385-397, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25832562
19.
Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.
Mol Pharm;
11(2): 477-85, 2014 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24380373
20.
Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.
Xenobiotica;
44(12): 1108-16, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24947446