Detalles de la búsqueda
1.
'Getting Better'-Is It a Feasible Strategy of Broad Pan-Antiherpesviral Drug Targeting by Using the Nuclear Egress-Directed Mechanism?
Int J Mol Sci;
25(5)2024 Feb 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38474070
2.
The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.
J Biol Chem;
298(3): 101625, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35074430
3.
Autofluorescent Artemisinin-Benzimidazole Hybrids via Organo-Click Reaction: Study of Antiviral Properties and Mode of Action in Living Cells.
Chemistry;
29(48): e202301194, 2023 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37267160
4.
The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7-Cyclin H Determines Individual Patterns of Transcription in Infected Cells.
Int J Mol Sci;
24(24)2023 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38139252
5.
Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models.
Chemistry;
28(4): e202200039, 2022 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35043485
6.
Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models.
Chemistry;
28(4): e202103861, 2022 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34859926
7.
Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations.
Int J Mol Sci;
23(5)2022 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35269635
8.
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.
Int J Mol Sci;
23(19)2022 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36233116
9.
High-resolution crystal structures of two prototypical ß- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity.
J Biol Chem;
295(10): 3189-3201, 2020 03 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31980459
10.
Phosphosite Analysis of the Cytomegaloviral mRNA Export Factor pUL69 Reveals Serines with Critical Importance for Recruitment of Cellular Proteins Pin1 and UAP56/URH49.
J Virol;
94(8)2020 03 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-31969433
11.
Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity.
Int J Mol Sci;
22(23)2021 Nov 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34884662
12.
Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs).
Int J Mol Sci;
22(2)2021 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33430060
13.
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.
J Biol Chem;
294(15): 6188-6203, 2019 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30782840
14.
Investigational Antiviral Therapy Models for the Prevention and Treatment of Congenital Cytomegalovirus Infection during Pregnancy.
Antimicrob Agents Chemother;
65(1)2020 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33077661
15.
Differential upregulation of host cell protein kinases by the replication of α-, ß- and γ-herpesviruses provides a signature of virus-specific signalling.
J Gen Virol;
101(3): 284-289, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31958050
16.
(Iso)Quinoline-Artemisinin Hybrids Prepared through Click Chemistry: Highly Potent Agents against Viruses.
Chemistry;
26(52): 12019-12026, 2020 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32485071
17.
The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism.
Int J Mol Sci;
21(15)2020 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32759737
18.
Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro.
Antimicrob Agents Chemother;
63(9)2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31262766
19.
Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.
J Virol;
92(15)2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29743376
20.
Visible-Light-Driven C-H Oxidation of Cyclic Tertiary Amines: Access to Synthetic Strychnos Alkaloids with Antiviral Activity.
Chemistry;
25(16): 4062-4066, 2019 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30620121