RESUMEN
We report a case of a 13-year-old girl with soft tissue sarcoma of the hand, which showed muscle and neuroectodermal immunophenotypes. Molecular studies were performed on RNA collected from fine-needle aspiration (FNA) cytology and peripheral blood samples by nested reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis. This biphenotypic tumor showed simultaneous expression of EWS-FLI1 and PAX3-FKHR transcripts, specific of Ewing family tumors and alveolar rhabdomyosarcoma, respectively. Although childhood sarcomas with simultaneous muscle and neural differentiation have been described to have EWS-FLI1 transcripts, there are no reports of tumors with both transcripts. Cytological specimens are a good source of RNA for molecular studies.
Asunto(s)
Neoplasias de los Músculos/patología , Tumores Neuroectodérmicos Periféricos Primitivos/patología , Sarcoma de Células Pequeñas/patología , Adolescente , Biomarcadores de Tumor/análisis , Southern Blotting , Quimera/genética , Femenino , Mano , Humanos , Inmunohistoquímica , Inmunofenotipificación , Hibridación Fluorescente in Situ , Imagen por Resonancia Magnética , Neoplasias de los Músculos/genética , Neoplasias de los Músculos/inmunología , Músculo Esquelético/inmunología , Músculo Esquelético/patología , Tumores Neuroectodérmicos Periféricos Primitivos/genética , Tumores Neuroectodérmicos Periféricos Primitivos/inmunología , Reacción en Cadena de la Polimerasa , ARN Neoplásico/análisis , Sarcoma de Células Pequeñas/genética , Sarcoma de Células Pequeñas/inmunologíaRESUMEN
Medullary thyroid carcinoma (MTC) is a rare malignancy which spreads frequently to cervical lymph nodes. We report the CT findings of MTC metastatic cervical adenopathies in two patients with previously resected MTC. The CT scans showed calcifications (one patient) and massive homogeneous postcontrast nodal enhancement. Medullary thyroid carcinoma should be included in the differential diagnosis of entities showing calcifications and intense homogeneous adenopathic enhancement on CT studies.