Detalles de la búsqueda
1.
Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis.
Neurobiol Dis;
192: 106430, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38325718
2.
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.
J Enzyme Inhib Med Chem;
39(1): 2301767, 2024 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38205514
3.
Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).
J Neurochem;
156(3): 379-390, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32628315
4.
Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3ß as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis.
Int J Mol Sci;
22(16)2021 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34445680
5.
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Proc Natl Acad Sci U S A;
114(6): E999-E1008, 2017 02 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28119500
6.
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.
J Enzyme Inhib Med Chem;
34(1): 87-96, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30362380
7.
Derivatives of the ß-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease.
Molecules;
24(7)2019 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30987121
8.
Designing multitarget ligands for neurodegenerative diseases with improved permeability trough PLGA nanoencapsulation.
Biomed Pharmacother;
175: 116626, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38663103
9.
Prenylated Flavanone Isolated from Dalea Species as a Potential Multitarget-Neuroprotector in an In Vitro Alzheimer's Disease Mice Model.
Neurotox Res;
42(2): 23, 2024 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38578482
10.
Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis.
Expert Opin Investig Drugs;
32(2): 141-160, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36762798
11.
TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer's disease patients.
Front Mol Neurosci;
16: 1243277, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37621404
12.
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J Med Chem;
65(2): 1585-1607, 2022 01 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34978799
13.
Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles.
Pharmaceutics;
13(2)2021 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33525757
14.
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
Eur J Med Chem;
210: 112968, 2021 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33139113
15.
Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment.
Sci Rep;
10(1): 4449, 2020 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32157143
16.
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3ß Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease.
ACS Chem Neurosci;
11(17): 2728-2740, 2020 09 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32663009
17.
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients.
Mol Neurobiol;
56(4): 2424-2432, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-30030753
18.
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library.
Nat Commun;
10(1): 2798, 2019 06 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31243268
19.
A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential.
ACS Chem Neurosci;
10(1): 279-294, 2019 01 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30253086
20.
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators.
J Med Chem;
61(14): 5910-5921, 2018 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29966094