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1.
Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy.
Breast Cancer Res Treat;
172(1): 69-82, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30056566
2.
Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.
PLoS Pathog;
12(6): e1005717, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27336364
3.
SU9516 Increases α7ß1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.
Mol Ther;
25(6): 1395-1407, 2017 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28391962
4.
Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.
Proc Natl Acad Sci U S A;
112(40): 12480-5, 2015 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26396258
5.
Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.
Proc Natl Acad Sci U S A;
111(31): 11365-70, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25049379
6.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Proc Natl Acad Sci U S A;
111(6): 2349-54, 2014 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-24469833
7.
Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling.
Mol Cancer Res;
21(4): 316-331, 2023 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36790955
8.
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
J Med Chem;
65(12): 8303-8331, 2022 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35696646
9.
Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.
Cancer Res;
80(12): 2689-2702, 2020 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32341035
10.
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J Med Chem;
63(5): 2013-2027, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31059256
11.
Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors.
Front Oncol;
9: 994, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31632920
12.
Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy.
SLAS Technol;
24(1): 28-40, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30289729
13.
Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype.
Mol Cancer Ther;
18(11): 2097-2110, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31395684
14.
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.
Cancer Res;
78(6): 1537-1548, 2018 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29343524
15.
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J Med Chem;
60(12): 4869-4881, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28557458
16.
Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens.
J Biomol Screen;
21(9): 942-55, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27112173
17.
Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins.
PLoS One;
11(8): e0161415, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27556570
18.
Large-scale pharmacological profiling of 3D tumor models of cancer cells.
Cell Death Dis;
7(12): e2492, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27906188
19.
Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma.
Oncotarget;
6(34): 35247-62, 2015 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-26497213
20.
High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.
Sci Rep;
5: 13891, 2015 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26403635