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1.

Oxidative addition of carbon dioxide into mesoionics.

Mathieu, Simon; Trinquier, Georges.

Phys Chem Chem Phys; 21(10): 5531-5565, 2019 Mar 06.

Artículo en Inglés | MEDLINE | ID: mdl-30785431

2.

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.

Lee, Wendy; Crawford, James J; Aliagas, Ignacio; Murray, Lesley J; Tay, Suzanne; Wang, Weiru; Heise, Christopher E; Hoeflich, Klaus P; La, Hank; Mathieu, Simon; Mintzer, Robert; Ramaswamy, Sreemathy; Rouge, Lionel; Rudolph, Joachim.

Bioorg Med Chem Lett; 26(15): 3518-24, 2016 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-27346791

3.

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.

Wenglowsky, Steve; Ren, Li; Grina, Jonas; Hansen, Joshua D; Laird, Ellen R; Moreno, David; Dinkel, Victoria; Gloor, Susan L; Hastings, Gregg; Rana, Sumeet; Rasor, Kevin; Sturgis, Hillary L; Voegtli, Walter C; Vigers, Guy; Willis, Brandon; Mathieu, Simon; Rudolph, Joachim.

Bioorg Med Chem Lett; 24(8): 1923-7, 2014 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-24675381

4.

Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.

Visser, Michael; Papillon, Julien P N; Luzzio, Michael; LaMarche, Matthew J; Fan, Jianmei; Michael, Walter; Wang, David; Zhang, Alan; Straub, Christopher; Mathieu, Simon; Kato, Mitsunori; Palermo, Mark; Chen, Christine; Ramsey, Timothy; Joud, Carol; Barrett, Rosemary; Vattay, Anthony; Guo, Ribo; Bric, Anka; Chung, Franklin; Liang, Guiqing; Romanowski, Michael J; Lam, Joni; Thohan, Sanjeev; Atassi, Faraj; Wylie, Andrew; Cooke, Vesselina G.

J Med Chem; 67(2): 1447-1459, 2024 Jan 25.

Artículo en Inglés | MEDLINE | ID: mdl-38198520

5.

The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.

Ren, Li; Ahrendt, Kateri A; Grina, Jonas; Laird, Ellen R; Buckmelter, Alex J; Hansen, Joshua D; Newhouse, Brad; Moreno, David; Wenglowsky, Steve; Dinkel, Victoria; Gloor, Susan L; Hastings, Gregg; Rana, Sumeet; Rasor, Kevin; Risom, Tyler; Sturgis, Hillary L; Voegtli, Walter C; Mathieu, Simon.

Bioorg Med Chem Lett; 22(10): 3387-91, 2012 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-22534450

6.

Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors.

Argikar, Upendra; Blatter, Markus; Bednarczyk, Dallas; Chen, Zhuoliang; Cho, Young Shin; Doré, Michaël; Dumouchel, Jennifer L; Ho, Samuel; Hoegenauer, Klemens; Kawanami, Toshio; Mathieu, Simon; Meredith, Erik; Möbitz, Henrik; Murphy, Stephen K; Parthasarathy, Saravanan; Soldermann, Carole Pissot; Santos, Jobette; Silver, Serena; Skolnik, Suzanne; Stojanovic, Aleksandar.

J Med Chem; 65(18): 12386-12402, 2022 09 22.

Artículo en Inglés | MEDLINE | ID: mdl-36069672

7.

Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.

Wenglowsky, Steve; Ahrendt, Kateri A; Buckmelter, Alex J; Feng, Bainian; Gloor, Susan L; Gradl, Stefan; Grina, Jonas; Hansen, Joshua D; Laird, Ellen R; Lunghofer, Paul; Mathieu, Simon; Moreno, David; Newhouse, Brad; Ren, Li; Risom, Tyler; Rudolph, Joachim; Seo, Jeongbeob; Sturgis, Hillary L; Voegtli, Walter C; Wen, Zhaoyang.

Bioorg Med Chem Lett; 21(18): 5533-7, 2011 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-21802293

8.

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor.

Heffron, Timothy P; Berry, Megan; Castanedo, Georgette; Chang, Christine; Chuckowree, Irina; Dotson, Jennafer; Folkes, Adrian; Gunzner, Janet; Lesnick, John D; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Olivero, Alan; Pang, Jodie; Peterson, David; Salphati, Laurent; Sampath, Deepak; Sideris, Steve; Sutherlin, Daniel P; Tsui, Vickie; Wan, Nan Chi; Wang, Shumei; Wong, Susan; Zhu, Bing-Yan.

Bioorg Med Chem Lett; 20(8): 2408-11, 2010 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-20346656

9.

The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma.

Rago, Florencia; Elliott, GiNell; Li, Ailing; Sprouffske, Kathleen; Kerr, Grainne; Desplat, Aurore; Abramowski, Dorothee; Chen, Julie T; Farsidjani, Ali; Xiang, Kay X; Bushold, Geoffrey; Feng, Yun; Shirley, Matthew D; Bric, Anka; Vattay, Anthony; Möbitz, Henrik; Nakajima, Katsumasa; Adair, Christopher D; Mathieu, Simon; Ntaganda, Rukundo; Smith, Troy; Papillon, Julien P N; Kauffmann, Audrey; Ruddy, David A; Bhang, Hyo-Eun C; Castelletti, Deborah; Jagani, Zainab.

Mol Cancer Ther; 19(10): 2186-2195, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32747420

10.

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

LaMarche, Matthew J; Acker, Michael; Argintaru, Andreea; Bauer, Daniel; Boisclair, Julie; Chan, Homan; Chen, Christine Hiu-Tung; Chen, Ying-Nan; Chen, Zhouliang; Deng, Zhan; Dore, Michael; Dunstan, David; Fan, Jianmei; Fekkes, Peter; Firestone, Brant; Fodor, Michelle; Garcia-Fortanet, Jorge; Fortin, Pascal D; Fridrich, Cary; Giraldes, John; Glick, Meir; Grunenfelder, Denise; Hao, Huia-Xiang; Hentemann, Martin; Ho, Samuel; Jouk, Andriana; Kang, Zhao B; Karki, Rajesh; Kato, Mitsunori; Keen, Nick; Koenig, Robert; LaBonte, Laura R; Larrow, Jay; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Mathieu, Simon; Meyer, Matthew J; Mohseni, Morvarid; Ntaganda, Rukundo; Palermo, Mark; Perez, Lawrence; Pu, Minying; Ramsey, Timothy; Reilly, John; Sarver, Patrick; Sellers, William R; Sendzik, Martin; Shultz, Michael D; Slisz, Joanna.

J Med Chem; 63(22): 13578-13594, 2020 11 25.

Artículo en Inglés | MEDLINE | ID: mdl-32910655

11.

Estimating the "steric clash" at cis peptide bonds.

Mathieu, Simon; Poteau, Romuald; Trinquier, Georges.

J Phys Chem B; 112(26): 7894-902, 2008 Jul 03.

Artículo en Inglés | MEDLINE | ID: mdl-18543981

12.

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

Papillon, Julien P N; Nakajima, Katsumasa; Adair, Christopher D; Hempel, Jonathan; Jouk, Andriana O; Karki, Rajeshri G; Mathieu, Simon; Möbitz, Henrik; Ntaganda, Rukundo; Smith, Troy; Visser, Michael; Hill, Susan E; Hurtado, Felipe Kellermann; Chenail, Gregg; Bhang, Hyo-Eun C; Bric, Anka; Xiang, Kay; Bushold, Geoffrey; Gilbert, Tamara; Vattay, Anthony; Dooley, Julie; Costa, Emily A; Park, Isabel; Li, Ailing; Farley, David; Lounkine, Eugen; Yue, Q Kimberley; Xie, Xiaoling; Zhu, Xiaoping; Kulathila, Raviraj; King, Daniel; Hu, Tiancen; Vulic, Katarina; Cantwell, John; Luu, Catherine; Jagani, Zainab.

J Med Chem; 61(22): 10155-10172, 2018 11 21.

Artículo en Inglés | MEDLINE | ID: mdl-30339381

13.

"Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.

Chen, Xin; Giraldes, John; Sprague, Elizabeth R; Shakya, Subarna; Chen, Zhuoliang; Wang, Yaping; Joud, Carol; Mathieu, Simon; Chen, Christine Hiu-Tung; Straub, Christopher; Duca, Jose; Hurov, Kristen; Yuan, Yanqiu; Shao, Wenlin; Touré, B Barry.

J Med Chem; 60(5): 2155-2161, 2017 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-28186750

14.

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

Touré, B Barry; Giraldes, John; Smith, Troy; Sprague, Elizabeth R; Wang, Yaping; Mathieu, Simon; Chen, Zhuoliang; Mishina, Yuji; Feng, Yun; Yan-Neale, Yan; Shakya, Subarna; Chen, Dongshu; Meyer, Matthew; Puleo, David; Brazell, J Tres; Straub, Christopher; Sage, David; Wright, Kirk; Yuan, Yanqiu; Chen, Xin; Duca, Jose; Kim, Sean; Tian, Li; Martin, Eric; Hurov, Kristen; Shao, Wenlin.

J Med Chem; 59(10): 4711-23, 2016 05 26.

Artículo en Inglés | MEDLINE | ID: mdl-27187609

15.

Electrophilic activation of lactams with Tf2O and pyridine: expedient synthesis of (+/-)-tetraponerine T4.

Charette, André B; Mathieu, Simon; Martel, Jonathan.

Org Lett; 7(24): 5401-4, 2005 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-16288516

16.

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

Crawford, James J; Lee, Wendy; Aliagas, Ignacio; Mathieu, Simon; Hoeflich, Klaus P; Zhou, Wei; Wang, Weiru; Rouge, Lionel; Murray, Lesley; La, Hank; Liu, Ning; Fan, Peter W; Cheong, Jonathan; Heise, Christopher E; Ramaswamy, Sreemathy; Mintzer, Robert; Liu, Yanzhou; Chao, Qi; Rudolph, Joachim.

J Med Chem; 58(12): 5121-36, 2015 Jun 25.

Artículo en Inglés | MEDLINE | ID: mdl-26030457

17.

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series.

Rudolph, Joachim; Aliagas, Ignacio; Crawford, James J; Mathieu, Simon; Lee, Wendy; Chao, Qi; Dong, Ping; Rouge, Lionel; Wang, Weiru; Heise, Christopher; Murray, Lesley J; La, Hank; Liu, Yanzhou; Manning, Gerard; Diederich, François; Hoeflich, Klaus P.

ACS Med Chem Lett; 6(6): 711-5, 2015 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-26101579

18.

The -BF-NH- link as a peptide-bond surrogate.

Mathieu, Simon; Trinquier, Georges.

J Phys Chem B; 116(30): 8863-72, 2012 Aug 02.

Artículo en Inglés | MEDLINE | ID: mdl-22794798

19.

Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.

Mathieu, Simon; Gradl, Stefan N; Ren, Li; Wen, Zhaoyang; Aliagas, Ignacio; Gunzner-Toste, Janet; Lee, Wendy; Pulk, Rebecca; Zhao, Guiling; Alicke, Bruno; Boggs, Jason W; Buckmelter, Alex J; Choo, Edna F; Dinkel, Victoria; Gloor, Susan L; Gould, Stephen E; Hansen, Joshua D; Hastings, Gregg; Hatzivassiliou, Georgia; Laird, Ellen R; Moreno, David; Ran, Yingqing; Voegtli, Walter C; Wenglowsky, Steve; Grina, Jonas; Rudolph, Joachim.

J Med Chem; 55(6): 2869-81, 2012 Mar 22.

Artículo en Inglés | MEDLINE | ID: mdl-22335519

20.

Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase ß isoform.

Heffron, Timothy P; Wei, Binqing; Olivero, Alan; Staben, Steven T; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing-Yan.

J Med Chem; 54(22): 7815-33, 2011 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-21985639

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