RESUMEN
BACKGROUND: Few systematic studies have examined the reasons why patients with bipolar disorder and substance use disorders misuse alcohol and drugs of abuse. Such reasons may depend heavily on context so qualitative research methods that made no prior theoretical assumptions were employed. We explored the reasons patients give for misusing drugs and alcohol and how these relate to their illness course. METHOD: Qualitative semi-structured interviews and thematic analysis with a purposive sample of 15 patients with bipolar disorder and a current or past history of drug or alcohol use disorders. RESULTS: Patients based their patterns of and reasons for substance use on previous personal experiences rather than other sources of information. Reasons for substance use were idiosyncratic, and were both mood related and unrelated. Contextual factors such as mood, drug and social often modified the patient's personal experience of substance use. Five thematic categories emerged: experimenting in the early illness; living with serious mental illness; enjoying the effects of substances; feeling normal; and managing stress. LIMITATIONS: The prevalence of these underlying themes was not established and the results may not apply to populations with different cultural norms. CONCLUSIONS: Patterns of substance use and reasons for use are idiosyncratic to the individual and evolve through personal experience. Motivating the patient to change their substance use requires an understanding of their previous personal experience of substance use both in relation to the different phases of their bipolar disorder and their wider personal needs.
Asunto(s)
Trastorno Bipolar/diagnóstico , Trastorno Bipolar/epidemiología , Trastornos Relacionados con Sustancias/etiología , Adolescente , Adulto , Anciano , Comorbilidad , Diagnóstico Dual (Psiquiatría) , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Índice de Severidad de la Enfermedad , Trastornos Relacionados con Sustancias/epidemiología , Trastornos Relacionados con Sustancias/psicología , Adulto JovenRESUMEN
BACKGROUND: Depression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied. AIMS: To determine the effects of depressive syndromes and cases of depression on the risk of incident dementia. METHOD: Participants in China and the UK aged > or =65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed 1 year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study). RESULTS: Incident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95% CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95% CI 1.25-4.89) and HR=2.62 (95% CI 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants. CONCLUSIONS: Only the most severe syndromes and cases of depression are a risk factor for dementia.
Asunto(s)
Demencia/etiología , Trastorno Depresivo/psicología , Factores de Edad , Anciano , Anciano de 80 o más Años , Envejecimiento/fisiología , China/epidemiología , Demencia/epidemiología , Trastorno Depresivo/epidemiología , Inglaterra/epidemiología , Estudios Epidemiológicos , Femenino , Humanos , Masculino , Escala del Estado Mental , Índice de Severidad de la EnfermedadRESUMEN
BACKGROUND: An elevated blood concentration of homocysteine is an established risk factor for cognitive impairment and dementia, but associations between cognition and methylmalonic acid (MMA), a related metabolic marker of vitamin B-12 deficiency, are less clear. OBJECTIVE: The aim was to determine the utility of serum MMA and holotranscobalamin as markers of vitamin B-12 status in relation to cognitive function and to investigate their association with discrete cognitive domains. DESIGN: This was a cross-sectional survey of 84 nondemented elderly participants (aged >69 y) from the Welsh cohort of the Medical Research Council's Cognitive Function and Ageing Study. Cognitive status was determined by Mini-Mental State Examination (MMSE) and the Cognitive Section of the Cambridge Mental Disorders of the Elderly Examination (CAMCOG). RESULTS: Nearly one-half (43%) of the persons selected had likely metabolically significant vitamin B-12 deficiency. Higher MMA concentrations were associated with lower MMSE scores independent of age and education (P = 0.007). MMA concentration correlated inversely with CAMCOG scores of ideational praxis (P < 0.05) and language comprehension (P < 0.05) and expression (P < 0.01). Serum folate correlated weakly but significantly with language (P < 0.05), remote memory (P < 0.05), and constructional and ideational praxis scores (P < 0.05 and P < 0.01, respectively). CONCLUSION: The high prevalence of likely metabolically significant vitamin B-12 deficiency in the elderly is associated with lower cognitive function scores and particularly with lower scores of language comprehension and expression.
Asunto(s)
Envejecimiento/fisiología , Cognición/fisiología , Ácido Metilmalónico/sangre , Deficiencia de Vitamina B 12/complicaciones , Complejo Vitamínico B/sangre , Anciano , Anciano de 80 o más Años , Envejecimiento/sangre , Estudios de Cohortes , Estudios Transversales , Femenino , Ácido Fólico/sangre , Deficiencia de Ácido Fólico/complicaciones , Deficiencia de Ácido Fólico/diagnóstico , Deficiencia de Ácido Fólico/epidemiología , Geriatría , Humanos , Pruebas del Lenguaje , Estudios Longitudinales , Masculino , Deficiencia de Vitamina B 12/epidemiologíaRESUMEN
BACKGROUND: Any hypothesis in longitudinal studies may be affected by attrition and poor response rates. The MRC Cognitive Function and Ageing study (MRC CFAS) is a population based longitudinal study in five centres with identical methodology in England and Wales each recruiting approximately 2,500 individuals. This paper aims to identify potential biases in the two-year follow-up interviews. METHODS: Initial non-response: Those not in the baseline interviews were compared in terms of mortality to those who were in the baseline interviews at the time of the second wave interviews (1993-1996). Longitudinal attrition: Logistic regression analysis was used to examine baseline differences between individuals who took part in the two-year longitudinal wave compared with those who did not. RESULTS: Initial non-response: Individuals who moved away after sampling but before baseline interview were 1.8 times more likely to die by two years (95% Confidence interval(CI) 1.3-2.4) compared to respondents, after adjusting for age. The refusers had a slightly higher, but similar mortality pattern to responders (Odds ratio 1.2, 95%CI 1.1-1.4). Longitudinal attrition: Predictors for drop out due to death were being older, male, having impaired activities of daily living, poor self-perceived health, poor cognitive ability and smoking. Similarly individuals who refused were more likely to have poor cognitive ability, but had less years of full-time education and were more often living in their own home though less likely to be living alone. There was a higher refusal rate in the rural centres. Individuals who moved away or were uncontactable were more likely to be single, smokers, demented or depressed and were less likely to have moved if in warden-controlled accommodation at baseline. CONCLUSIONS: Longitudinal estimation of factors mentioned above could be biased, particularly cognitive ability and estimates of movements from own home to residential homes. However, these differences could also affect other investigations, particularly the estimates of incidence and longitudinal effects of health and psychiatric diseases, where the factors shown here to be associated with attrition are risk factors for the diseases. All longitudinal studies should investigate attrition and this may help with aspects of design and with the analysis of specific hypotheses.
Asunto(s)
Sesgo , Demencia/epidemiología , Estudios Longitudinales , Mortalidad , Negativa a Participar , Distribución por Edad , Anciano , Cognición , Inglaterra/epidemiología , Femenino , Conductas Relacionadas con la Salud , Humanos , Entrevistas como Asunto , Modelos Logísticos , Masculino , Oportunidad Relativa , Pacientes Desistentes del Tratamiento , Factores de Riesgo , Asunción de Riesgos , Gales/epidemiologíaRESUMEN
OBJECTIVE: To identify the communication skills medical trainees perceive themselves to avoid or use during initial clinical encounters and the areas of communication learning need they identify. METHODS: 446 2nd year undergraduate medical students were invited to take part in the study. Details of four encounters with patients were entered into a web-based electronic logbook by the student. Details included perception of use, success and requests for further training from a list of communication process skills. RESULTS: 395 (89%) students took part. Factor analysis yielded three types of skills: those used to manage the flow of interaction; the emotional content of the interaction; and structuring the interaction. Skills perceived as being used least often and least successfully and identified by the students as requiring further training were primarily those that involved managing the emotional aspects of interactions with patients rather than managing the flow of information. CONCLUSION: Communication training should focus further on the emotional aspects of patient interactions in order to support students during early clinical encounters. PRACTICE IMPLICATIONS: Skills required to manage emotional encounters need to be made more explicit to students. Opportunities to obtain feedback and develop competency should be offered as part of the core curriculum.
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Competencia Clínica , Comunicación , Educación de Pregrado en Medicina , Relaciones Médico-Paciente , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Emociones , Inglaterra , Análisis Factorial , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Conducting long-term nutrition intervention studies on cognition can be challenging. The gaps in current methodology are addressed via a case study of the relationship between vitamin B(12) and cognition in people aged 60 and older. There is robust evidence from many observational studies, both cross-sectional and longitudinal, showing that a deficit of the vitamin is associated with poor or declining cognition in this age group, but supplementation of the vitamin in trials does not bring about improved cognition. The evidence from observational studies as well as clinical trials is reviewed here, and the potential difficulties in conducting long-term nutritional intervention studies in this area are highlighted.
Asunto(s)
Cognición/fisiología , Deficiencia de Vitamina B 12/fisiopatología , Vitamina B 12/administración & dosificación , Anciano , Cognición/efectos de los fármacos , Trastornos del Conocimiento/prevención & control , Trastornos del Conocimiento/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Vitamina B 12/uso terapéuticoRESUMEN
BACKGROUND: Little is known about patterns of healthcare use by people with depression in Europe. AIMS: To examine the use and cost of services by adults with depressive or adjustment disorders in five European countries, and predictive factors. METHOD: People aged 18-65 years with depressive or adjustment disorders (n=427) in Ireland, Finland, Norway, Spain and the UK provided information on predisposition (demographics, social support), enablement (country, urban/rural, social function) and need (symptom severity, perceived health status) for services. Outcome measures were self-reported use Client Services Receipt Interview and costs of general practice, generic, psychiatric or social services in the past 6 months. RESULTS: Less frequent use was made of generic services in Norway and psychiatric services in the UK. Severity of depression, perceived health status, social functioning and level of social support were significant predictors of use; the number of people able to provide support was positively associated with greater health service use. CONCLUSIONS: Individual participant factors provided greater explanatory power than national differences in healthcare delivery. The association between social support and service use suggests that interventions may be needed for those who lack social support.
Asunto(s)
Trastorno Depresivo/psicología , Costos de la Atención en Salud , Aceptación de la Atención de Salud/psicología , Adolescente , Adulto , Anciano , Trastorno Depresivo/economía , Trastorno Depresivo/epidemiología , Europa (Continente)/epidemiología , Femenino , Humanos , Masculino , Servicios de Salud Mental , Persona de Mediana Edad , Vigilancia de la Población/métodos , Atención Primaria de Salud , Psicotrópicos/economía , Psicotrópicos/uso terapéutico , Índice de Severidad de la Enfermedad , Apoyo Social , Servicio Social , Factores SocioeconómicosRESUMEN
BACKGROUND: Substantial variation in the prevalence of Dementia with Lewy Bodies (DLB) has been reported with estimates ranging from 0 to 26.3% of all dementia cases, potentially making it the second most common dementia subtype. OBJECTIVES: The aim of this study was to review systematically and critically for the first time previous studies of the clinical prevalence and incidence of DLB in the population. METHODS: A systematic literature search was performed using PubMed. Selected articles had to describe an original study that provided a prevalence and/or incidence number for the whole population for DLB as defined by pre-set clinical criteria and findings. RESULTS: Six studies reporting the prevalence of DLB and one study reporting the incidence of DLB met the inclusion criteria. Prevalence estimates, depending on case criteria, range from 0 to 5% with regard to the general population, and from 0 to 30.5% of all dementia cases. The only estimate for DLB incidence is 0.1% a year for the general population and 3.2% a year for all new dementia cases. The number of available studies was too small to hypothesise on the potential effect of age, sex and genetic background on the results. CONCLUSIONS: Although the literature on the prevalence and incidence of DLB is limited, there is a general consensus that DLB must be considered in the range of neurodegenerative conditions in the elderly. The move towards use of consensus criteria facilitates comparison and is welcome. Their application in a more routine way towards rigorously defined and selected study populations will lead to more comparable and generalisable studies in the future.