Detalles de la búsqueda
1.
Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.
Haematologica;
2024 Feb 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38426275
2.
Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.
Int J Mol Sci;
22(11)2021 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34205123
3.
An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs.
Int J Mol Sci;
21(12)2020 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32630605
4.
A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens.
Mar Drugs;
17(8)2019 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31443260
5.
[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.
Molecules;
24(22)2019 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31766108
6.
Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
Am J Physiol Renal Physiol;
315(1): F57-F73, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29537311
7.
Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Hum Mol Genet;
25(11): 2245-2255, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27053712
8.
TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Proc Natl Acad Sci U S A;
112(47): E6486-95, 2015 Nov 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26604306
9.
Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.
Molecules;
23(2)2018 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29364148
10.
Development of Kinase Inhibitors via Metal-Catalyzed Câ»H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.
Molecules;
23(9)2018 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-30158487
11.
N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1δ/ε inhibitors: Synthesis, biological evaluation and molecular modeling studies.
Bioorg Med Chem Lett;
27(12): 2663-2667, 2017 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28487075
12.
Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.
Mar Drugs;
15(10)2017 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29039762
13.
Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance.
Int J Mol Sci;
18(10)2017 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28984824
14.
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Antimicrob Agents Chemother;
60(5): 2822-33, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26902771
15.
Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.
Bioorg Med Chem Lett;
26(17): 4327-9, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27469128
16.
5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms.
Bioorg Med Chem;
24(16): 3790-800, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27349574
17.
Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor.
J Nat Prod;
79(11): 2953-2960, 2016 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933894
18.
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
Proc Natl Acad Sci U S A;
110(48): 19525-30, 2013 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-24218572
19.
Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.
Molecules;
21(6)2016 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27322235
20.
Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.
Molecules;
21(5)2016 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-27144552