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1.
Int J Immunopathol Pharmacol ; 24(3): 793-5, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21978711

RESUMEN

We describe a 79-year-old female with a chronic venous ulceration infected by Staphylococcus aureus and Enterococcus faecalis and not responsive to conventional treatments. The patient was treated with Methyl-Aminolaevulinate Photodynamic Therapy (MAL-PDT). After four weeks the cutaneous swabs become negative and we observed a significant clinical improvement. Therefore we suppose that MALPDT could represent a valid therapeutic option in the treatment of infected chronic ulcers.


Asunto(s)
Ácido Aminolevulínico/análogos & derivados , Antibacterianos/uso terapéutico , Fotoquimioterapia , Fármacos Fotosensibilizantes/uso terapéutico , Úlcera Cutánea/tratamiento farmacológico , Úlcera Cutánea/microbiología , Administración Tópica , Anciano , Ácido Aminolevulínico/efectos adversos , Ácido Aminolevulínico/uso terapéutico , Antibacterianos/efectos adversos , Femenino , Humanos , Fotoquimioterapia/efectos adversos , Fármacos Fotosensibilizantes/efectos adversos , Piel/microbiología , Piel/patología , Resultado del Tratamiento
2.
Biomed Pharmacother ; 61(8): 488-93, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17604940

RESUMEN

(18)F-Fluorodeoxyglucose positron emission tomography (FDG-PET) thyroid incidentalomas are defined abnormal FDG uptake in the thyroid gland found at PET scan performed as part of a staging protocol and follow-up of patients with various kinds of malignancies. In the present study we report two cases of FDG PET thyroid incidentalomas, and review the literature with regard to the meaning of this new category of thyroid "disease". Since the advent of whole body FDG PET scan, a relatively high incidence of cases of thyroid FDG uptake has been reported as an incidental finding as in one of our patient. Focal uptake was found to be more likely associated to a malignant lesion, while a diffuse thyroid uptake to a benign thyroid disease. However, differential diagnosis is difficult, and reported data in literature are somewhat discordant. A focal thyroid uptake of FDG incidentally discovered at PET scan cannot be invariably considered a malignant thyroid nodule, however a prompt and complete work-up including laboratory examinations, ultrasonography and fine needle aspiration cytology, should be obtained to exclude a thyroid carcinoma. On the other hand, patients with a PET finding of diffuse FDG uptake can be considered at low risk of malignancy, being more likely associated to chronic thyroiditis or diffuse thyroid autonomy.


Asunto(s)
Fluorodesoxiglucosa F18 , Radiofármacos , Glándula Tiroides/diagnóstico por imagen , Neoplasias de la Tiroides/diagnóstico por imagen , Carcinoma Papilar/complicaciones , Carcinoma Papilar/diagnóstico por imagen , Femenino , Humanos , Linfoma de Células B/complicaciones , Linfoma Folicular/complicaciones , Masculino , Persona de Mediana Edad , Tomografía de Emisión de Positrones , Neoplasias de la Tiroides/complicaciones , Nódulo Tiroideo/complicaciones , Nódulo Tiroideo/diagnóstico por imagen
3.
Hum Immunol ; 40(2): 138-42, 1994 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-7928444

RESUMEN

This study reports the HLA-DR and DQ molecular characterization of 62 CD patients of Sardinian descent. Patients were divided in two groups (36 in group I and 26 in group II) according to the clinical features at the disease onset. Among the patients of group I, having the fully expressed form of CD and a mean age of 3 years at disease onset, a significant increase of DRB1*0301, DQA1*0501, DQB1*0201 homozygotes, encoding in cis two DQ (alpha 1*0501, beta 1*0201) susceptibility heterodimers, was observed when compared either with the patients of group II (pIII < 0.012) or with healthy individuals (pI < 10(-6)). On the other hand, in the patients of group II, presenting oligosymptomatic forms and a mean age of 5.7 years at the disease onset, the haplotype combinations encoding in cis or in trans only one DQ (alpha 1*0501, beta 1*0201) heterodimer were significantly increased in comparison either with the patients of group I (pIII < 0.026) or with controls (pII < 10(-6)). These findings suggest that a double dose of DQA1*0501, DQB1*0201 genes may predispose a person to an earlier onset and to more severe disease manifestations. Genotype analysis showed that only three patients (all in group I) failed to form in trans or in cis the DQ (alpha 1*0501, beta 1*0201) heterodimer and carried the DQA1*0101,DQB1*0501 haplotype, suggesting its possible role in CD susceptibility. In addition, a significant increment of DQB1*0501 gene (pc < 0.0065) was found comparing the frequency of DQB1 alleles in CD patients and healthy controls, after exclusion of DQB1*0201 chromosomes.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Enfermedad Celíaca/genética , Enfermedad Celíaca/fisiopatología , Dosificación de Gen , Antígenos HLA-D/genética , Adulto , Edad de Inicio , Niño , Preescolar , Femenino , Antígenos HLA-DQ/genética , Cadenas alfa de HLA-DQ , Cadenas beta de HLA-DQ , Antígenos HLA-DR/genética , Cadenas HLA-DRB1 , Haplotipos/genética , Antígenos de Histocompatibilidad Clase II/genética , Humanos , Masculino , Persona de Mediana Edad
4.
Stud Health Technol Inform ; 44: 95-111, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-10175346

RESUMEN

This chapter describes the characteristics and preliminary evaluation of The Virtual Environment for Body Image Modification (VEBIM), a set of tasks aimed at treating body image disturbances and body dissatisfaction associated with eating disorders. Two methods are commonly used to treat body image: (1) a cognitive/behavioural therapy to influence patients' feelings of dissatisfaction; (2) a visual/motorial therapy with the aim of influencing the level of bodily awareness. VEBIM tries to integrate these two therapeutic approaches within an immersive virtual environment. This choice would not only make it possible to intervene simultaneously on all of the forms of bodily representations, but also to use the psycho-physiological effects provoked on the body by the virtual experience for therapeutic purposes. The chapter, together with the description of the VEBIM theoretical approach, it also presents a study on two preliminary samples (71 normal subjects, uncontrolled study, 48 normal subjects, controlled study) to test its efficacy.


Asunto(s)
Imagen Corporal , Gráficos por Computador , Simulación por Computador , Trastornos Mentales/terapia , Adulto , Femenino , Humanos , Masculino , Trastornos Mentales/psicología
5.
Stud Health Technol Inform ; 39: 34-45, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-10168930

RESUMEN

Virtual Reality Environments for Psychoneurophysiological Assessment and Rehabilitation-is an European Community funded project (Telematics for health-HC 1053 http:/(/)www.etho.be/ht_projects/vrepar/) whose aim is: to develop a PC based virtual reality system (PC-VRS) for the medical market that can be marketed at a price which is accessible to its possible end-users (hospitals, universities and research centres) and which would have the modular, connectability and interoperability characteristics that the existing systems lack; to develop three hardware/software modules for the application of the PC VRS in psychoneurophysiological assessment and rehabilitation. The chosen development areas are eating disorders (bulimia, anorexia and obesity), movement disorders (Parkinson's disease and torsion dystonia) and stroke disorders (unilateral neglect and hemiparesis). This paper presents the rationale of the different approaches and the methodology used.


Asunto(s)
Trastornos Cerebrovasculares/rehabilitación , Diagnóstico por Computador/métodos , Trastornos de Alimentación y de la Ingestión de Alimentos/rehabilitación , Trastornos del Movimiento/rehabilitación , Interfaz Usuario-Computador , Trastornos Cerebrovasculares/diagnóstico , Trastornos de Alimentación y de la Ingestión de Alimentos/diagnóstico , Humanos , Trastornos del Movimiento/diagnóstico , Terapia Asistida por Computador
6.
Eur J Phys Rehabil Med ; 49(3): 273-81, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23172400

RESUMEN

BACKGROUND: Management of chronic mechanical neck pain (CMNP) still represents a challenge. A patient-oriented (Pa-O) therapeutic approach could be considered as the one in which therapies are scheduled at the start of each therapeutic session according to the patient's current physical status, and differs from a prescription-oriented (Pr-O) therapeutic approach, in which therapies are prescribed at the first medical referral and are not adjusted at any time during the treatment period. AIM: To determine if a Pa-O approach may be more beneficial for CMNP patients when compared to a Pr-O one. DESIGN: Randomized controlled trial. POPULATION: 220 CMNP outpatients randomized to either Pa-O group (N.=114) or Pr-O group (N.=106). METHODS: Each group received 10 therapeutic sessions over 3 weeks. Primary outcome measures were pain assessment, evaluated by Visual-Analog-Scale (VAS), and disability level, evaluated by the Neck Pain and Disability Scale (NPDS-I). Secondary outcome measures included patients' response to treatment and treatment failures. Measurements were carried out at baseline (T0) and 1 month after treatment ended (T1). Data were analysed according to the intention-to-treat principle. RESULTS: Patients in both groups displayed at T1 a significant reduction in VAS and NPDS-I scores. The relative changes at T1 were greater in Pa-O group when compared with Pr-O group both for VAS (61.5% versus 48.8%; P<0.005) and for NPDS-I scores (48.4% versus 36.8%; P<0.05). CONCLUSION: A Pa-O approach may be more beneficial in terms of pain and disability improvement in the short-term follow-up in suffers from CMNP. However, the occurrence of a performance-bias due to the increased level of attention from physicians to patients in Pa-O group, cannot be ruled-out. CLINICAL REHABILITATION IMPACT: A Pa-O approach should be considered for CMNP also in an outpatient facility.


Asunto(s)
Dolor de Cuello/rehabilitación , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Evaluación de la Discapacidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Rehabilitación/métodos , Adulto Joven
9.
J Infect ; 54(2): e55-7, 2007 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-16716405

RESUMEN

Herpes simplex virus type 2 (HSV-2) infection was one of the first opportunistic infections identified among patients with AIDS. In the literature there are many data suggesting that the natural history of HSV-2 infection is altered in HIV-HSV-2 co-infected patients. Furthermore, a relationship between HIV seropositivity and HBV infection because of their analogous way of transmission is also described. We report the case of a 37-year-old patient who suffered from multiple painful ulcerative lesions of the perianal region. Laboratory examination showed positivity for HIV and HBV infections. In HIV-positive patients perianal HSV-2 can have atypical manifestations, especially if co-infection by Candida albicans occurs.


Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/complicaciones , Candida albicans , Candidiasis/complicaciones , Herpes Genital/patología , Herpesvirus Humano 2/patogenicidad , Enfermedades de la Piel/patología , Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Infecciones Oportunistas Relacionadas con el SIDA/virología , Adulto , Canal Anal/patología , Candidiasis/microbiología , Femenino , Infecciones por VIH/complicaciones , VIH-1 , Herpes Genital/virología , Humanos , Enfermedades de la Piel/virología
10.
Plant Physiol ; 125(4): 2040-52, 2001 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11299383

RESUMEN

The walls deposited by growing pollen tubes contain two types of beta-glucan, the (1,3)-beta-glucan callose and the (1,4)-beta-glucan cellulose, as well as various alpha-linked pectic polysaccharides. Pollen tubes of Nicotiana alata Link et Otto, an ornamental tobacco, were therefore used to identify genes potentially encoding catalytic subunits of the callose synthase and cellulose synthase enzymes. Reverse transcriptase-polymerase chain reactions (RT-PCR) with pollen-tube RNA and primers designed to conserved regions of bacterial and plant cellulose synthase (CesA) genes amplified a fragment that corresponded to an abundantly expressed cellulose-synthase-like gene named NaCslD1. A fragment from a true CesA gene (NaCesA1) was also amplified, but corresponding cDNAs could not be identified in a pollen-tube library, consistent with the very low level of expression of the NaCesA1 gene. RT-PCR with pollen-tube RNA and primers designed to regions conserved between the fungal FKS genes [that encode (1,3)-beta-glucan synthases] and their presumed plant homologs (the Gsl or glucan-synthase-like genes) amplified a fragment that corresponded to an abundantly expressed gene named NaGsl1. A second Gsl gene detected by RT-PCR (NaGsl2) was expressed at low levels in immature floral organs. The structure of full-length cDNAs of NaCslD1, NaCesA1, and NaGsl1 are presented. Both NaCslD1 and NaGsl1 are predominantly expressed in the male gametophyte (developing and mature pollen and growing pollen tubes), and we propose that they encode the catalytic subunits of two beta-glucan synthases involved in pollen-tube wall synthesis. Different beta-glucans deposited in one cell type may therefore be synthesized by enzymes from different gene families.


Asunto(s)
Proteínas de Arabidopsis , Regulación de la Expresión Génica de las Plantas , Glucosiltransferasas/genética , Proteínas de la Membrana , Nicotiana/enzimología , Nicotiana/genética , Plantas Tóxicas , Polen/enzimología , Proteínas de Schizosaccharomyces pombe , Secuencia de Aminoácidos , Secuencia Conservada , Cartilla de ADN , Regulación Enzimológica de la Expresión Génica , Biblioteca de Genes , Glucosiltransferasas/química , Modelos Moleculares , Datos de Secuencia Molecular , Filogenia , Tallos de la Planta/enzimología , Polen/genética , Estructura Secundaria de Proteína , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Alineación de Secuencia , Homología de Secuencia de Aminoácido , Transcripción Genética
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