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1.

Large neutral amino acid levels tune perinatal neuronal excitability and survival.

Knaus, Lisa S; Basilico, Bernadette; Malzl, Daniel; Gerykova Bujalkova, Maria; Smogavec, Mateja; Schwarz, Lena A; Gorkiewicz, Sarah; Amberg, Nicole; Pauler, Florian M; Knittl-Frank, Christian; Tassinari, Marianna; Maulide, Nuno; Rülicke, Thomas; Menche, Jörg; Hippenmeyer, Simon; Novarino, Gaia.

Cell; 186(9): 1950-1967.e25, 2023 04 27.

Artículo en Inglés | MEDLINE | ID: mdl-36996814

2.

A proteome-scale map of the human interactome network.

Rolland, Thomas; Tasan, Murat; Charloteaux, Benoit; Pevzner, Samuel J; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E; Braun, Pascal; Brehme, Marc; Broly, Martin P; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J; Hardy, Madeleine F; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R; Palagi, Alexandre; Poulin, Matthew M; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M; Scholz, Annemarie; Shah, Akash A; Sharma, Amitabh.

Cell; 159(5): 1212-1226, 2014 11 20.

Artículo en Inglés | MEDLINE | ID: mdl-25416956

3.

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.

Lercher, Alexander; Bhattacharya, Anannya; Popa, Alexandra M; Caldera, Michael; Schlapansky, Moritz F; Baazim, Hatoon; Agerer, Benedikt; Gürtl, Bettina; Kosack, Lindsay; Májek, Peter; Brunner, Julia S; Vitko, Dijana; Pinter, Theresa; Genger, Jakob-Wendelin; Orlova, Anna; Pikor, Natalia; Reil, Daniela; Ozsvár-Kozma, Maria; Kalinke, Ulrich; Ludewig, Burkhard; Moriggl, Richard; Bennett, Keiryn L; Menche, Jörg; Cheng, Paul N; Schabbauer, Gernot; Trauner, Michael; Klavins, Kristaps; Bergthaler, Andreas.

Immunity; 51(6): 1074-1087.e9, 2019 12 17.

Artículo en Inglés | MEDLINE | ID: mdl-31784108

4.

Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.

Mayor-Ruiz, Cristina; Jaeger, Martin G; Bauer, Sophie; Brand, Matthias; Sin, Celine; Hanzl, Alexander; Mueller, André C; Menche, Jörg; Winter, Georg E.

Mol Cell; 75(4): 849-858.e8, 2019 08 22.

Artículo en Inglés | MEDLINE | ID: mdl-31442425

5.

Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.

Block, Jana; Rashkova, Christina; Castanon, Irinka; Zoghi, Samaneh; Platon, Jessica; Ardy, Rico C; Fujiwara, Mitsuhiro; Chaves, Beatriz; Schoppmeyer, Rouven; van der Made, Caspar I; Jimenez Heredia, Raul; Harms, Frederike L; Alavi, Samin; Alsina, Laia; Sanchez Moreno, Paula; Ávila Polo, Rainiero; Cabrera-Pérez, Rocío; Kostel Bal, Sevgi; Pfajfer, Laurène; Ransmayr, Bernhard; Mautner, Anna-Katharina; Kondo, Ryohei; Tinnacher, Anna; Caldera, Michael; Schuster, Michael; Domínguez Conde, Cecilia; Platzer, René; Salzer, Elisabeth; Boyer, Thomas; Brunner, Han G; Nooitgedagt-Frons, Judith E; Iglesias, Estíbaliz; Deyà-Martinez, Angela; Camacho-Lovillo, Marisol; Menche, Jörg; Bock, Christoph; Huppa, Johannes B; Pickl, Winfried F; Distel, Martin; Yoder, Jeffrey A; Traver, David; Engelhardt, Karin R; Linden, Tobias; Kager, Leo; Hannich, J Thomas; Hoischen, Alexander; Hambleton, Sophie; Illsinger, Sabine; Da Costa, Lydie; Kutsche, Kerstin.

N Engl J Med; 389(6): 527-539, 2023 Aug 10.

Artículo en Inglés | MEDLINE | ID: mdl-37342957

6.

The immune system as a social network.

Bergthaler, Andreas; Menche, Jörg.

Nat Immunol; 18(5): 481-482, 2017 04 18.

Artículo en Inglés | MEDLINE | ID: mdl-28418389

7.

BioProfiling.jl: profiling biological perturbations with high-content imaging in single cells and heterogeneous populations.

Vulliard, Loan; Hancock, Joel; Kamnev, Anton; Fell, Christopher W; Ferreira da Silva, Joana; Loizou, Joanna I; Nagy, Vanja; Dupré, Loïc; Menche, Jörg.

Bioinformatics; 38(6): 1692-1699, 2022 03 04.

Artículo en Inglés | MEDLINE | ID: mdl-34935929

8.

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms.

Schischlik, Fiorella; Jäger, Roland; Rosebrock, Felix; Hug, Eva; Schuster, Michael; Holly, Raimund; Fuchs, Elisabeth; Milosevic Feenstra, Jelena D; Bogner, Edith; Gisslinger, Bettina; Schalling, Martin; Rumi, Elisa; Pietra, Daniela; Fischer, Gottfried; Faé, Ingrid; Vulliard, Loan; Menche, Jörg; Haferlach, Torsten; Meggendorfer, Manja; Stengel, Anna; Bock, Christoph; Cazzola, Mario; Gisslinger, Heinz; Kralovics, Robert.

Blood; 134(2): 199-210, 2019 07 11.

Artículo en Inglés | MEDLINE | ID: mdl-31064751

9.

B Cell-Activating Factor Neutralization Aggravates Atherosclerosis.

Tsiantoulas, Dimitrios; Sage, Andrew P; Göderle, Laura; Ozsvar-Kozma, Maria; Murphy, Deirdre; Porsch, Florentina; Pasterkamp, Gerard; Menche, Jörg; Schneider, Pascal; Mallat, Ziad; Binder, Christoph J.

Circulation; 138(20): 2263-2273, 2018 11 13.

Artículo en Inglés | MEDLINE | ID: mdl-29858401

10.

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.

Khamina, Kseniya; Lercher, Alexander; Caldera, Michael; Schliehe, Christopher; Vilagos, Bojan; Sahin, Mehmet; Kosack, Lindsay; Bhattacharya, Anannya; Májek, Peter; Stukalov, Alexey; Sacco, Roberto; James, Leo C; Pinschewer, Daniel D; Bennett, Keiryn L; Menche, Jörg; Bergthaler, Andreas.

PLoS Pathog; 13(12): e1006758, 2017 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-29261807

11.

A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor.

Licciardello, Marco P; Ringler, Anna; Markt, Patrick; Klepsch, Freya; Lardeau, Charles-Hugues; Sdelci, Sara; Schirghuber, Erika; Müller, André C; Caldera, Michael; Wagner, Anja; Herzog, Rebecca; Penz, Thomas; Schuster, Michael; Boidol, Bernd; Dürnberger, Gerhard; Folkvaljon, Yasin; Stattin, Pär; Ivanov, Vladimir; Colinge, Jacques; Bock, Christoph; Kratochwill, Klaus; Menche, Jörg; Bennett, Keiryn L; Kubicek, Stefan.

Nat Chem Biol; 13(7): 771-778, 2017 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-28530711

12.

Non-classical monocytes as mediators of tissue destruction in arthritis.

Puchner, Antonia; Saferding, Victoria; Bonelli, Michael; Mikami, Yohei; Hofmann, Melanie; Brunner, Julia S; Caldera, Michael; Goncalves-Alves, Eliana; Binder, Nikolaus B; Fischer, Anita; Simader, Elisabeth; Steiner, Carl-Walter; Leiss, Harald; Hayer, Silvia; Niederreiter, Birgit; Karonitsch, Thomas; Koenders, Marije I; Podesser, Bruno K; O'Shea, John J; Menche, Jörg; Smolen, Josef S; Redlich, Kurt; Blüml, Stephan.

Ann Rheum Dis; 77(10): 1490-1497, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-29959183

13.

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.

Sharma, Amitabh; Menche, Jörg; Huang, C Chris; Ort, Tatiana; Zhou, Xiaobo; Kitsak, Maksim; Sahni, Nidhi; Thibault, Derek; Voung, Linh; Guo, Feng; Ghiassian, Susan Dina; Gulbahce, Natali; Baribaud, Frédéric; Tocker, Joel; Dobrin, Radu; Barnathan, Elliot; Liu, Hao; Panettieri, Reynold A; Tantisira, Kelan G; Qiu, Weiliang; Raby, Benjamin A; Silverman, Edwin K; Vidal, Marc; Weiss, Scott T; Barabási, Albert-László.

Hum Mol Genet; 24(11): 3005-20, 2015 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-25586491

14.

An inter-species protein-protein interaction network across vast evolutionary distance.

Zhong, Quan; Pevzner, Samuel J; Hao, Tong; Wang, Yang; Mosca, Roberto; Menche, Jörg; Taipale, Mikko; Tasan, Murat; Fan, Changyu; Yang, Xinping; Haley, Patrick; Murray, Ryan R; Mer, Flora; Gebreab, Fana; Tam, Stanley; MacWilliams, Andrew; Dricot, Amélie; Reichert, Patrick; Santhanam, Balaji; Ghamsari, Lila; Calderwood, Michael A; Rolland, Thomas; Charloteaux, Benoit; Lindquist, Susan; Barabási, Albert-László; Hill, David E; Aloy, Patrick; Cusick, Michael E; Xia, Yu; Roth, Frederick P; Vidal, Marc.

Mol Syst Biol; 12(4): 865, 2016 Apr 22.

Artículo en Inglés | MEDLINE | ID: mdl-27107014

15.

From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration.

Gomez-Cabrero, David; Menche, Jörg; Vargas, Claudia; Cano, Isaac; Maier, Dieter; Barabási, Albert-László; Tegnér, Jesper; Roca, Josep.

BMC Bioinformatics; 17(Suppl 15): 441, 2016 Nov 22.

Artículo en Inglés | MEDLINE | ID: mdl-28185567

16.

A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins in the human interactome.

Ghiassian, Susan Dina; Menche, Jörg; Barabási, Albert-László.

PLoS Comput Biol; 11(4): e1004120, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25853560

17.

Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation.

Thian, Marini; Hoeger, Birgit; Kamnev, Anton; Poyer, Fiona; Köstel Bal, Sevgi; Caldera, Michael; Jiménez-Heredia, Raúl; Huemer, Jakob; Pickl, Winfried F; Groß, Miriam; Ehl, Stephan; Lucas, Carrie L; Menche, Jörg; Hutter, Caroline; Attarbaschi, Andishe; Dupré, Loïc; Boztug, Kaan.

Haematologica; 105(10): e488, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-33054089

18.

Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits.

Sharma, Amitabh; Gulbahce, Natali; Pevzner, Samuel J; Menche, Jörg; Ladenvall, Claes; Folkersen, Lasse; Eriksson, Per; Orho-Melander, Marju; Barabási, Albert-László.

Mol Cell Proteomics; 12(11): 3398-408, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-23882023

19.

Systems Medicine: from molecular features and models to the clinic in COPD.

Gomez-Cabrero, David; Menche, Jörg; Cano, Isaac; Abugessaisa, Imad; Huertas-Migueláñez, Mercedes; Tenyi, Akos; Marin de Mas, Igor; Kiani, Narsis A; Marabita, Francesco; Falciani, Francesco; Burrowes, Kelly; Maier, Dieter; Wagner, Peter; Selivanov, Vitaly; Cascante, Marta; Roca, Josep; Barabási, Albert-László; Tegnér, Jesper.

J Transl Med; 12 Suppl 2: S4, 2014 Nov 28.

Artículo en Inglés | MEDLINE | ID: mdl-25471042

20.

Pan-cancer analysis of the interplay between mutational signatures and cellular signaling.

Hakobyan, Anna; Meyenberg, Mathilde; Vardazaryan, Nelli; Hancock, Joel; Vulliard, Loan; Loizou, Joanna I; Menche, Jörg.

iScience; 27(6): 109873, 2024 Jun 21.

Artículo en Inglés | MEDLINE | ID: mdl-38783997

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