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1.

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia.

Baryawno, Ninib; Przybylski, Dariusz; Kowalczyk, Monika S; Kfoury, Youmna; Severe, Nicolas; Gustafsson, Karin; Kokkaliaris, Konstantinos D; Mercier, Francois; Tabaka, Marcin; Hofree, Matan; Dionne, Danielle; Papazian, Ani; Lee, Dongjun; Ashenberg, Orr; Subramanian, Ayshwarya; Vaishnav, Eeshit Dhaval; Rozenblatt-Rosen, Orit; Regev, Aviv; Scadden, David T.

Cell; 177(7): 1915-1932.e16, 2019 06 13.

Artículo en Inglés | MEDLINE | ID: mdl-31130381

2.

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.

Hoggatt, Jonathan; Singh, Pratibha; Tate, Tiffany A; Chou, Bin-Kuan; Datari, Shruti R; Fukuda, Seiji; Liu, Liqiong; Kharchenko, Peter V; Schajnovitz, Amir; Baryawno, Ninib; Mercier, Francois E; Boyer, Joseph; Gardner, Jason; Morrow, Dwight M; Scadden, David T; Pelus, Louis M.

Cell; 172(1-2): 191-204.e10, 2018 01 11.

Artículo en Inglés | MEDLINE | ID: mdl-29224778

3.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes, David B; Kfoury, Youmna S; Mercier, François E; Wawer, Mathias J; Law, Jason M; Haynes, Mark K; Lewis, Timothy A; Schajnovitz, Amir; Jain, Esha; Lee, Dongjun; Meyer, Hanna; Pierce, Kerry A; Tolliday, Nicola J; Waller, Anna; Ferrara, Steven J; Eheim, Ashley L; Stoeckigt, Detlef; Maxcy, Katrina L; Cobert, Julien M; Bachand, Jacqueline; Szekely, Brian A; Mukherjee, Siddhartha; Sklar, Larry A; Kotz, Joanne D; Clish, Clary B; Sadreyev, Ruslan I; Clemons, Paul A; Janzer, Andreas; Schreiber, Stuart L; Scadden, David T.

Cell; 167(1): 171-186.e15, 2016 Sep 22.

Artículo en Inglés | MEDLINE | ID: mdl-27641501

4.

Not All Created Equal: Lineage Hard-Wiring in the Production of Blood.

Mercier, Francois E; Scadden, David T.

Cell; 163(7): 1568-70, 2015 Dec 17.

Artículo en Inglés | MEDLINE | ID: mdl-26687347

5.

Xist RNA is a potent suppressor of hematologic cancer in mice.

Yildirim, Eda; Kirby, James E; Brown, Diane E; Mercier, Francois E; Sadreyev, Ruslan I; Scadden, David T; Lee, Jeannie T.

Cell; 152(4): 727-42, 2013 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-23415223

6.

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Sykes, Stephen M; Lane, Steven W; Bullinger, Lars; Kalaitzidis, Demetrios; Yusuf, Rushdia; Saez, Borja; Ferraro, Francesca; Mercier, Francois; Singh, Harshabad; Brumme, Kristina M; Acharya, Sanket S; Scholl, Claudia; Schöll, Claudia; Tothova, Zuzana; Attar, Eyal C; Fröhling, Stefan; DePinho, Ronald A; Armstrong, Scott A; Gilliland, D Gary; Scadden, David T.

Cell; 146(5): 697-708, 2011 Sep 02.

Artículo en Inglés | MEDLINE | ID: mdl-21884932

7.

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.

Man, Cheuk Him; Mercier, Francois E; Liu, Nian; Dong, Wentao; Stephanopoulos, Gregory; Jiang, Li; Jung, Yookyung; Lin, Charles P; Leung, Anskar Y H; Scadden, David T.

Blood; 139(4): 502-522, 2022 01 27.

Artículo en Inglés | MEDLINE | ID: mdl-34610101

8.

SnapShot: The hematopoietic stem cell niche.

Kfoury, Youmna; Mercier, Francois; Scadden, David T.

Cell; 158(1): 228-228.e1, 2014 Jul 03.

Artículo en Inglés | MEDLINE | ID: mdl-24995988

9.

Duration of and time to response in oncology clinical trials from the perspective of the estimand framework.

Weber, Hans-Jochen; Corson, Stephen; Li, Jiang; Mercier, François; Roychoudhury, Satrajit; Sailer, Martin Oliver; Sun, Steven; Todd, Alexander; Yung, Godwin.

Pharm Stat; 23(1): 91-106, 2024.

Artículo en Inglés | MEDLINE | ID: mdl-37786317

10.

Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.

Bruno, René; Chanu, Pascal; Kågedal, Matts; Mercier, Francois; Yoshida, Kenta; Guedj, Jérémie; Li, Chunze; Beyer, Ulrich; Jin, Jin Y.

Br J Cancer; 129(9): 1383-1388, 2023 10.

Artículo en Inglés | MEDLINE | ID: mdl-36765177

11.

Progression signature underlies clonal evolution and dissemination of multiple myeloma.

Shen, Yu Jia; Mishima, Yuji; Shi, Jiantao; Sklavenitis-Pistofidis, Romanos; Redd, Robert A; Moschetta, Michele; Manier, Salomon; Roccaro, Aldo M; Sacco, Antonio; Tai, Yu-Tzu; Mercier, Francois; Kawano, Yawara; Su, Nang Kham; Berrios, Brianna; Doench, John G; Root, David E; Michor, Franziska; Scadden, David T; Ghobrial, Irene M.

Blood; 137(17): 2360-2372, 2021 04 29.

Artículo en Inglés | MEDLINE | ID: mdl-33150374

12.

CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia.

Alayoubi, Abdulfatah M; Khawaji, Zakaria Y; Mohammed, Mohammed A; Mercier, François E.

Ann Hematol; 2023 Sep 22.

Artículo en Inglés | MEDLINE | ID: mdl-37736806

13.

Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra-individual heterogeneity in patients with advanced cancer.

Kerioui, Marion; Beaulieu, Maxime; Desmée, Solène; Bertrand, Julie; Mercier, François; Jin, Jin Y; Bruno, René; Guedj, Jérémie.

Biometrics; 79(4): 3752-3763, 2023 12.

Artículo en Inglés | MEDLINE | ID: mdl-37498050

14.

Defining estimands for efficacy assessment in single arm phase 1b or phase 2 clinical trials in oncology early development.

Englert, Stefan; Mercier, François; Pilling, Elizabeth A; Homer, Victoria; Habermehl, Christina; Zimmermann, Stefan; Kan-Dobrosky, Natalia.

Pharm Stat; 22(5): 921-937, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-37403434

15.

Metabolomic Study Using Time-of-Flight Mass Spectrometry Reveals Novel Urinary Biomarkers for Gaucher Disease Type 1.

Menkovic, Iskren; Boutin, Michel; Alayoubi, Abdulfatah; Curado, Filipa; Bauer, Peter; Mercier, François E; Auray-Blais, Christiane.

J Proteome Res; 21(5): 1321-1329, 2022 05 06.

Artículo en Inglés | MEDLINE | ID: mdl-35349295

16.

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.

Yusuf, Rushdia Zareen; Saez, Borja; Sharda, Azeem; van Gastel, Nick; Yu, Vionnie W C; Baryawno, Ninib; Scadden, Elizabeth W; Acharya, Sanket; Chattophadhyay, Shrikanta; Huang, Cherrie; Viswanathan, Vasanthi; S'aulis, Dana; Cobert, Julien; Sykes, David B; Keibler, Mark A; Das, Sudeshna; Hutchinson, John N; Churchill, Michael; Mukherjee, Siddhartha; Lee, Dongjun; Mercier, Francois; Doench, John; Bullinger, Lars; Logan, David J; Schreiber, Stuart; Stephanopoulos, Gregory; Rizzo, William B; Scadden, David T.

Blood; 136(11): 1303-1316, 2020 09 10.

Artículo en Inglés | MEDLINE | ID: mdl-32458004

17.

In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK).

Meneses-Lorente, Georgina; Fowler, Stephen; Guerini, Elena; Kowalski, Karey; Chow-Maneval, Edna; Yu, Li; Mercier, Francois; Ullah, Mohammed; Umehara, Kenichi; Brink, Andreas; Buchheit, Vincent; Zwanziger, Elke; Phipps, Alex; Djebli, Nassim.

Invest New Drugs; 40(1): 68-80, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-34417912

18.

Extending the Continual Reassessment Method to accommodate step-up dosing in Phase I trials.

Braun, Thomas M; Mercier, Francois.

Stat Med; 41(20): 3975-3990, 2022 09 10.

Artículo en Inglés | MEDLINE | ID: mdl-35662077

19.

Modelling the association between biomarkers and clinical outcome: An introduction to nonlinear joint models.

Kerioui, Marion; Bertrand, Julie; Bruno, René; Mercier, François; Guedj, Jérémie; Desmée, Solène.

Br J Clin Pharmacol; 88(4): 1452-1463, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-34993985

20.

Impact of model misspecification on model-based tests in PK studies with parallel design: real case and simulation studies.

Guhl, Mélanie; Mercier, François; Hofmann, Carsten; Sharan, Satish; Donnelly, Mark; Feng, Kairui; Sun, Wanjie; Sun, Guoying; Grosser, Stella; Zhao, Liang; Fang, Lanyan; Mentré, France; Comets, Emmanuelle; Bertrand, Julie.

J Pharmacokinet Pharmacodyn; 49(5): 557-577, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-36112338

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