Hydronephrosis index: a better physiological reference in antenatal ultrasound for assessment of fetal hydronephrosis.

OBJECTIVE: To establish a nomogram of fetal hydronephrosis index (HI) (anteroposterior diameter of renal pelvis divided by urinary bladder volume) at different gestational ages, to serve as a new reference for antenatal ultrasound examination, and to avoid overestimation of fetal hydronephrosis due to transient effect of a distended fetal bladder. STUDY DESIGN: 504 uncomplicated singleton pregnancies from 20 to 38 weeks' gestation were included. In each fetus, the maximum anteroposterior diameters of both renal pelves were measured on transverse view of fetal kidneys. Urinary bladder volume was calculated using the ovoid volume formula. HI was derived accordingly. RESULTS: Values of HI vary significantly at different trimesters of pregnancy. HI was much higher (mean = 0.1543) from 20 to 27 weeks' gestation, and its value decreased significantly (mean = 0.0253) from 28 to 38 weeks' gestation (P < .05, independent-sample t test). As gestational age increased, HI decreased (R(2) = 0.5921). CONCLUSIONS: HI is easy to be measured and can be used as a new physiological reference for assessment of fetal hydronephrosis by eliminating the confounding effect of a full fetal bladder. The change in values of HI throughout gestation supports the clinical importance of a nomogram for this new index.

Magnetic resonance angiography of coronary arteries with a 3-dimensional magnetization-prepared true fast imaging with steady-state precession sequence compared with conventional coronary angiography.

BACKGROUND: The aim of the study was to compare the detection of clinically significant coronary artery stenosis using a magnetic resonance 3-dimensional (3D) breath-hold true fast imaging with steady-state precession (trueFISP) sequence with conventional coronary angiography. METHODS: Twenty-nine patients who were scheduled to undergo or had recently undergone diagnostic conventional coronary angiogram participated in this study. The left main, left anterior descending, left circumflex, and right coronary arteries were studied using the 3D breath-hold trueFISP technique. Each artery was imaged with 1 acquisition in 16 to 32 heartbeats. The image quality, vessel length, and presence or absence of stenosis were evaluated. A score of 1 to 3 (1 = noninterpretable, 2 = good, 3 = excellent) was used to assess image quality. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of magnetic resonance angiography in detecting significant coronary artery stenosis (> 50% luminal narrowing) on conventional coronary angiogram were calculated. RESULTS: Of 116 vessels, 108 were assessed in 29 patients. Twenty vessels that had image quality score of 1 were excluded from further evaluation. The mean lengths of vessels visualized were the following: left anterior descending 3.6 cm, left circumflex 3.4 cm, and right coronary 6.6 cm. The entire length of the left main coronary artery was visualized. For the visualized arterial segments, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for detecting significant coronary artery stenosis were 92.8%, 95.3%, 95.0%, 68.4%, and 99.2%, respectively. CONCLUSIONS: The 3D breath-hold trueFISP technique, which uses the endogenous contrast of blood, is potentially useful in ruling out significant coronary artery stenosis but not yet sensitive enough as a screening tool.

Characteristics of the bladder in infants with urinary tract infections: an ultrasound study.

BACKGROUND: Patients with urinary tract infection (UTI) are known to have impaired bladder function as demonstrated by urodynamic (UD) studies. UD is rarely performed in infants. OBJECTIVE: To evaluate bladder function in infants with UTI using a dynamic US protocol. Maximal bladder volume (MaxBV), residual volume (RV) and bladder wall thickness (BWT) were measured and compared with values from normal controls. MATERIALS AND METHODS: A total of 57 consecutive infants (47 males, 10 females; mean age 0.48+/-0.30 years) with proven UTI, and 63 age-matched normal controls (37 males, 26 females; mean age 0.47+/-0.37 years) were recruited. MaxBV was determined just before voiding, and RV and BWT were measured after spontaneous voiding. RESULTS: Infants with UTI had smaller MaxBV (34.89 vs. 42.91 ml), larger RV (3.46 vs. 1.51 ml) and greater BWT (4.21 vs. 3.68 mm) than normal infants (P<0.05, Mann-Whitney test). CONCLUSION: Smaller bladder volume, larger residual volume and thicker bladder wall in infants with UTI can be explained by bladder instability, hypercontractility and infection-induced oedema of the bladder wall during UTI. The US measurement of bladder parameters might serve as an objective guide for clinical diagnosis and allow objective evaluation of bladder function during posttreatment follow-up.

Gender difference in achieving rate of maturity of the vesicoureteric junction.

BACKGROUND: Our previous study on the Doppler waveform of the urinary jet at the vesicoureteric junction (VUJ) indicates that there is an active sphincteric mechanism in humans. We have also shown that there are immature and mature patterns of the jet, and the VUJ matures around the age of 4 years. OBJECTIVE: To determine if there is any gender difference in the time of achieving maturity of the VUJ. MATERIALS AND METHODS: The Doppler pattern of the jets from both ureters was recorded in 273 normal boys and 248 normal girls. The subjects were considered to have immaturity of the VUJ if an immature jet waveform was detected in either ureter. RESULTS: The mean age of VUJ maturity was 4.54 years for the whole population, 4.88 years for boys and 4.34 years for girls. The difference between ROC curves for boys and girls was not significant (P > 0.05, simple Z test). CONCLUSION: There is no significant gender difference in the maturation of the VUJ. Detection of a persistent immature jet pattern beyond the age of maturity might have prognostic implications if there is a concurrent pathological condition related to the urinary tract in children.

Doppler waveforms of the ureteric jet: an overview and implications for the presence of a functional sphincter at the vesicoureteric junction.

This paper is a comprehensive review of the Doppler waveform appearance of ureteric jets. Six jet waveform patterns have been identified: monophasic, biphasic, triphasic, polyphasic, square and continuous. Details of the physical properties of jet patterns and their changes under various physiological conditions are illustrated. The immature monophasic ureteric jet pattern is common in infancy and early childhood up to around 4 years of age. This pattern is also noted to have a high incidence in older children with urinary tract infection/vesicoureteric reflux, nocturnal enuresis and in other special physiological conditions such as in children undergoing general anaesthesia, in women during pregnancy, and in patients who have had ureteric transplantation. A hypothesis of dual myogenic and neurogenic components is proposed to explain the mode of action of the vesicoureteric junction (VUJ). The implication of this hypothesis is that it alters the scientific basis of the understanding of the VUJ. Furthermore, the application of colour Doppler US to ureteric jets may provide a non-invasive technique to study the physiology or pathophysiology of the VUJ in humans. This might shed light on new novel approaches to the monitoring and treatment of diseases related to VUJ function.

Nomograms of total renal volume, urinary bladder volume and bladder wall thickness index in 3,376 children with a normal urinary tract.

BACKGROUND: We have previously shown that urinary bladder volume index (BVI = length x width x depth of bladder) and bladder volume wall thickness index (BVWI = BVI at full bladder/average bladder wall thickness) are useful indicators of bladder dysfunction in children with enuresis and urinary tract infection. These indices show a good correlation with urodynamic studies. We have expanded the study to include normal paediatric subjects with a wide age range. We illustrate a simple sonography protocol with nomograms of different parameters, which provide useful references for functional assessment in children with urological abnormalities. OBJECTIVE: To construct nomograms of total renal volume, maximum BVI and BVWI based on a Chinese paediatric population with age range from newborn to adolescence. MATERIALS AND METHODS: Sonography was performed in consecutive children with normal urinary tracts on imaging, using a standardized protocol. Data were collected for construction of nomograms for different parameters. RESULTS: Nomograms of total renal volume, BVI and BVWI were constructed based on 3,376 consecutive paediatric subjects. All parameters consistently increased with age. CONCLUSION: Nomograms of total renal volume, BVI and BVWI could provide useful references for studying bladder dysfunction in children using noninvasive dynamic sonography.

Scintigraphic detection of 'yo-yo' phenomenon in incomplete ureteric duplication.

'Yo-yo' reflux in an incompletely duplicated renal system was demonstrated on (99m)Tc-mercaptoacetyltriglycine (MAG3) renal scintigraphy in a 7-year-old girl presenting with low-grade fever and pyelonephritis. Incomplete duplication and a bifid renal pelvis, which may be seen in up to 4% of the North American population, occasionally causes symptoms because of recurrent urinary tract infection or loin pain. (99m)Tc-MAG3 renal scintigraphy can demonstrate 'yo-yo' reflux in patients with incomplete renal duplication and should be considered in cases with unexplained loin pain, even if (99m)Tc-dimercaptosuccinic acid (DMSA) renal scintigraphy is normal.

Congenital abdominal aortic aneurysm and renal dysplasia.

We report a 6-month-old boy with abdominal aortic aneurysm and dysplastic kidneys. To the best of our knowledge, this is the first report of abdominal aortic aneurysm associated with dysplastic kidneys. Serial US, MR angiography and scintigraphy were performed. No underlying cause of the aneurysm was identified. Spontaneous thrombosis occurred within 2.5 years of diagnosis, but there was persistent renovascular hypertension and progressive deterioration of renal function.

Comparison of thoracic ultrasound, clinical acumen, and radiography in patients with minor chest injury.

BACKGROUND: This study was designed to compare ultrasonography, clinical findings, and radiography in the detection of rib and sternal fractures. METHODS: In a prospective study, 88 patients presenting consecutively to an emergency department with isolated blunt chest injury of mild to moderate force were recruited. RESULTS: Ultrasonography yielded a sensitivity of 80.3 (95% confidence interval [CI], 69.5-88.5) for detecting chest wall fractures compared with sensitivities of 26.0 (95% CI, 15.8-36.3) for clinical acumen and 23.7 (95% CI, 14.7-34.8) for radiography. CONCLUSION: Early ultrasonography is more accurate than clinical and radiologic evaluation at detecting rib and sternal fractures.

Blood flow volume quantification of cerebral ischemia: comparison of three noninvasive imaging techniques of carotid and vertebral arteries.

OBJECTIVE: Determination of blood flow volume is useful in assessing ischemic cerebrovascular disease. We compared the blood flow volume measurement of three noninvasive imaging techniques, namely color velocity imaging quantification, spectral Doppler imaging quantification, and MR phase-contrast flow quantification, to see how well the flow values determined by each technique agreed with one another. SUBJECTS AND METHODS: Flow volume quantification was tested experimentally using a flow simulator and by the three techniques in the vertebral and internal carotid arteries of 40 patients with histories of cerebral ischemia. In the flow simulation study, the flow values in each technique were compared with the phantom flow by the Wilcoxon's signed rank test. In the patient study, the flow values between each paired technique were compared by paired t test. The significance level was taken at p less than 0.05. RESULTS: Flow volumes were measured by color velocity imaging quantification. MR phase-contrast flow quantification agreed with the phantom flow simulation within the tested range, and spectral Doppler imaging quantification values were significantly overestimated. In patients, a large variation of the blood flow volume was obtained between each technique (p < 0.05). Among them, spectral Doppler imaging quantification showed the highest flow values in the vessels (internal carotid arteries, 312.6 mL/min; vertebral arteries, 112.0 mL/min), followed by color velocity imaging quantification (internal carotid arteries, 216.8 mL/min; vertebral arteries, 58.1 mL/min) and MR phase-contrast flow quantification (internal carotid arteries, 169.1 mL/min; vertebral arteries, 66.5 mL/min). CONCLUSION: Blood flow volume measurements determined by the three noninvasive imaging techniques on the same vessel can differ widely, and spectral Doppler imaging quantification consistently overestimated the flow volume. It is, therefore, essential that the same technique, preferably color velocity imaging quantification or MR phase-contrast flow quantification, be used for clinical follow-up investigations in the future.

Correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis.

OBJECTIVE: To record the correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. METHODS: Women with palpable breast masses scheduled for excision biopsy were scanned with two- and three-dimensional color power Doppler sonography before and after the administration of a sonographic contrast agent. Vessel counts were performed on two- and three-dimensional sonographic images before and after contrast agent administration. All tumors were surgically removed and underwent immunohistochemical analysis for microvessel density assessment. The sonographic measure of tumor vascularity was correlated with microvessel density. RESULTS: Pathologic examination showed 43 breast cancers and 14 benign breast masses. Higher microvessel density was noted in malignant than benign breast masses (P < .0005). Color power Doppler sonographic measurement of tumor vessel number showed a significant positive correlation with tumor size (P < .05) and progesterone receptor negativity (P < .05). A significant positive correlation was observed between microvessel density and the number of intratumoral blood vessels assessed by both two- and three-dimensional color power Doppler sonography (P < .05). Regression models showed three-dimensional color power Doppler sonography to have a significantly higher correlation with microvessel density when compared with two-dimensional color power Doppler sonography at baseline (P < .005). The administration of a sonographic contrast agent did not improve correlation with microvessel density. CONCLUSIONS: A significant correlation was shown between color power Doppler sonographic measurement of tumor vascularity and microvessel density by immunohistochemical analysis. Further improvement in Doppler sonographic techniques to map capillary vessel flow should be explored to improve the current association with pathologic findings.

Sonography of plantar fibromatosis.

OBJECTIVE: Plantar fibromatosis is a rare benign fibroproliferative disorder of the plantar fascia that can be evaluated on sonography. Our study details the sonographic appearances of plantar fibromatosis. MATERIALS AND METHODS: We conducted a retrospective review of the clinical presentation, sonographic appearances, and clinical progress in 14 patients (range, 35-85 years; mean age, 53.1 years;) with plantar fibromatosis. Sonography was performed using either a 13-5-MHz multidimensional or 12.5-MHz linear array transducer. The location, sonographic appearances, and size of the plantar fibromatosis nodules were noted and correlated with symptom duration and clinical outcome. RESULTS: A total of 25 fibromatosis nodules in 19 feet were examined. On sonography, plantar fibromatosis was seen as a discrete fusiform nodular thickening of the plantar fascia, separate from the calcaneal insertion. Approximately one third (36%) of lesions were bilateral, and one quarter (26%) were multiple. All lesions were located either medially (60%) or centrally (40%) in the fascia. Most were hypoechoic (76%), were well defined (64%), and showed no acoustic enhancement (80%) or intrinsic vascularity (92%). No correlation was found between the echogenicity and size of plantar fibromatosis nodules or duration of symptoms (p < 0.01). One quarter of the affected feet had coexistent thickening of the plantar fascia at the calcaneal insertion with no related symptoms. CONCLUSION: Although the sonographic appearances of plantar fibromatosis vary, the appearances are characteristic enough to allow a specific diagnosis to be made. No clear relationship was found among the sonographic appearances, duration of symptoms, or clinical outcome.

Cerebral blood flow measurement by color velocity imaging in radiation-induced carotid stenosis.

OBJECTIVE: To show whether there is any association between the development of neurologic symptoms and the total cerebral blood flow volume documented by color velocity imaging in patients with carotid stenosis that develops after radiotherapy. METHODS: Twenty-three patients with nasopharyngeal carcinoma (4 female and 19 male; age range, 39-69 years; mean age, 55.6 years) and major extracranial carotid stenosis underwent color velocity imaging. In this group, 8 patients had symptoms of a stroke or transient ischemic attack, and the other 15 patients were asymptomatic. The color velocity imaging results in the symptomatic group were then compared with those in the asymptomatic group. RESULTS: The cerebral blood flow in the symptomatic group was significantly lower than that in the asymptomatic group (224.1 +/- 89.0 versus 532.5 +/- 89.0 mL/min; P = .001). CONCLUSIONS: Cerebral blood flow as measured by color velocity imaging was lower in the symptomatic group. There is an association between the development of neurologic symptoms and blood flow volume.

Imaging of musculoskeletal tuberculosis: a new look at an old disease.

There are certain imaging features that help to differentiate tuberculosis from other bone and joint disorders with a similar presentation. The current authors discuss these distinguishing imaging features particularly with respect to ultrasound, computed tomography, and magnetic resonance imaging. The judicious and appropriate use of these newer imaging modalities coupled with aspiration or biopsy can lead to earlier recognition of musculoskeletal tuberculosis before the onset of debilitating disease.

Treatment of pyogenic liver abscess: prospective randomized comparison of catheter drainage and needle aspiration.

This study aims to compare the therapeutic effectiveness of continuous catheter drainage versus intermittent needle aspiration in the percutaneous treatment of pyogenic liver abscesses. Over a 5-year period, 64 consecutive patients with pyogenic liver abscess were treated with intravenous antibiotics (ampicillin, cefuroxime, and metronidazole) and randomized into two percutaneous treatment groups: continuous catheter drainage (with an 8F multi-sidehole pigtail catheter); and intermittent needle aspiration (18G disposable trocar needle). There was no statistically significant difference between the two groups regarding patient demographics, underlying coexisting disease, abscess size, abscess number, number of loculation of abscess, the presenting clinical symptoms such as fever, abdominal pain, and pretreatment liver function test. Although not statistically significant, the duration of intravenous antibiotics treatment before percutaneous treatment was longer with the catheter group, and the change of antibiotics after the sensitivity test was more frequent with the needle group. The needle group was associated with a higher treatment success rate, a shorter duration of hospital stay, and a lower mortality rate, although this did not reach statistical significance. In conclusion, this study suggests that intermittent needle aspiration is probably as effective as continuous catheter drainage for the treatment of pyogenic liver abscess, although further proof with a large-scale study is necessary. Due to the additional advantages of procedure simplicity, patient comfort, and reduced price, needle aspiration deserves to be considered as a first-line drainage approach.

Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke.

BACKGROUND: At present there is no simple, accurate blood test that may be used to determine the severity of stroke or to predict mortality and morbidity in stroke patients presenting to emergency departments. METHODS: Patients with stroke-like symptoms who presented to an emergency department of a university hospital in Hong Kong were recruited for the study. DNA extracted from patients' plasma was analyzed for the beta-globin gene with a fluorescent-based PCR test. The primary outcome measures were in-hospital and 6-month mortality and morbidity using the post-stroke modified Rankin Score. RESULTS: Among the 88 consecutive patients recruited to the study, 70 (80%) had ischemic stroke, 11 (13%) had intracerebral hemorrhage, and 7 (8%) had transient ischemic attacks. Median plasma DNA concentrations taken within 3 h of symptom onset were higher in patients who died compared with those who survived at discharge (6205 vs 1334 kilogenome-equivalents/L; P = 0.03). Among patients with NIH Stroke Scale scores >8, median plasma DNA concentrations were higher in patients who died compared with those who survived to 6 months (2273 vs 968 kilogenome-equivalents/L; P = 0.002). Plasma DNA concentrations correlated with the volume of cerebral hematoma (r = 0.66; P = 0.03). Plasma DNA concentrations >1400 kilogenome-equivalents/L had a sensitivity of 100% and a specificity of 74.4% for predicting hospital mortality after stroke, and the area under the ROC curve was 0.89 (95% confidence interval, 0.80-0.94). The adjusted odds ratio for plasma DNA concentrations predicting 6-month mortality was 1.6 (1.1-2.4; P = 0.03) and for predicting 6-month post-Rankin Score >2 was 1.8 (1.0-3.3; P = 0.05). CONCLUSION: Plasma DNA concentrations correlate with stroke severity and may be used to predict mortality and morbidity in the emergency room.

White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy.

PURPOSE: To assess the development of white matter and cerebral metabolite changes during and after treatment in children with acute lymphoblastic leukemia. MATERIALS AND METHODS: Twenty-three children (10 boys, mean age of 6.3 years; 13 girls, mean age of 6.6 years) with acute lymphoblastic leukemia were examined prospectively with magnetic resonance (MR) imaging and MR spectroscopy at 0, 8, and 20 weeks and 1, 2, and 3 years after diagnosis. White matter changes were diagnosed on the basis of hyperintense abnormalities on T2-weighted MR images. Single-voxel hydrogen 1 MR spectroscopy results from the right frontoparietal region of 21 children who received intravenous high-dose methotrexate were analyzed for cerebral metabolite changes. Multilevel models were used to assess the change in metabolites from baseline levels at subsequent follow-up. RESULTS: At 20 weeks, MR spectroscopy showed a significant reduction (P <.05) of mean N-acetylaspartate to choline ratio and increase in mean choline to creatine ratio (P <.05) in the children given high-dose methotrexate. This decline in N-acetylaspartate to choline ratio subsequently reversed and increased, possibly because of normal age-related brain maturation. Seventeen of 21 (81%) children showed metabolite changes at MR spectroscopy, while five of 22 (23%) showed white matter changes at MR imaging at 20 weeks. One more child developed white matter changes at 32 weeks. The associated changes resolved or reduced with time. CONCLUSION: MR spectroscopy demonstrated metabolite changes in the brain after high-dose methotrexate treatment in the absence of structural white matter abnormalities at MR imaging. MR spectroscopy might thus be a more sensitive method of monitoring the effects of high-dose methotrexate in the brain.

Metabolic control patterns in acute phase and regenerating human liver determined in vivo by 31-phosphorus magnetic resonance spectroscopy.

OBJECTIVE: To elucidate the metabolic changes occurring within hepatocytes during acute phase reaction and liver regeneration. SUMMARY BACKGROUND DATA: The metabolic events occurring within the liver during the hepatic stress response are poorly understood. The authors used in vivo 31-phosphorus magnetic resonance spectroscopy to study hepatic metabolism after surgical trauma with and without loss of liver cell mass. METHODS: Three groups were studied: five patients undergoing partial hepatectomy; five patients in whom laparotomy and colonic resection was performed; and five patients treated by thyroidectomy. Hepatic metabolism was evaluated by 31-phosphorus magnetic resonance spectroscopy before surgery and serially thereafter on postoperative days 2, 4, 6, 14, and 28. Estimation of liver volume by magnetic resonance imaging and blood sampling for biochemistry were performed at the same time points. RESULTS: The authors found that alterations in hepatocyte phospholipid metabolism occurred after surgery that were correlated with changes in circulating acute phase proteins. Liver regeneration after hepatectomy was also associated with a derangement in energy metabolism, measured by a decrease in the ratio of ATP to its hydrolysis product inorganic phosphate. The depleted energy status was mirrored in biochemical indices of liver function, and restitution paralleled the course of restoration of hepatic cell mass. CONCLUSIONS: These findings indicate that changes in liver metabolism after surgery reflect the magnitude of tissue injury and the quantity of functioning liver cells. Acute phase responses dominate the initial recovery period at the expense of less important endergonic functions. When liver parenchyma is lost, the acute phase reaction is maintained and further supported by a rapid replenishment of hepatocytes, which can even be considered a continuation of acute phase physiology. Modulation of liver function within the framework of overall hepatic energy economy is one mechanism for matching energy supply with increased demands during these processes.

Severe acute respiratory syndrome (SARS): chest radiographic features in children.

BACKGROUND: Severe acute respiratory syndrome (SARS) is a recently recognized condition of viral origin associated with substantial morbidity and mortality rates in adults. Little information is available on its radiologic manifestations in children. OBJECTIVE: The goal of this study was to characterize the radiographic presentation of children with SARS. MATERIALS AND METHODS: We abstracted data (n=62) on the radiologic appearance and course of SARS in pediatric patients with suspect (n=25) or probable (n=37) SARS, diagnosed in five hospital sites located in three cities: Toronto, Singapore, and Hong Kong. Available chest radiographs and thoracic CTs were reviewed for the presence of the following radiographic findings: airspace disease, air bronchograms, airways inflammation and peribronchial thickening, interstitial disease, pleural effusion, and hilar adenopathy. RESULTS: A total of 62 patients (suspect=25, probable=37) were evaluated for SARS. Patient ages ranged from 5.5 months to 17 years and 11.5 months (average, 6 years and 10 months) with a female-to-male ratio of 32:30. Forty-one patients (66.1%) were in close contact with other probable, suspect, or quarantined cases; 10 patients (16.1%) had recently traveled to WHO-designated affected areas within 10 days; and 7 patients (11.2%) were transferred from other hospitals that had SARS patients. Three patients, who did not have close/hospital contact or travel history to affected areas, were classified as SARS cases based on their clinical signs and symptoms and on the fact that they were living in an endemic area. The most prominent clinical presentations were fever, with a temperature over 38 degrees C (100%), cough (62.9%), rhinorrhea (22.6%), myalgia (17.7%), chills (14.5%), and headache (11.3%). Other findings included sore throat (9.7%), gastrointestinal symptoms (9.7%), rigor (8.1%), and lethargy (6.5%). In general, fever and cough were the most common clinical presentations amongst younger pediatric SARS cases (age<10 years), whereas, in addition to these symptoms, headache, myalgia, sore throat, chills, and/or rigor were common in older patients (age>/=10 years). The chest radiographs of 35.5% of patients were normal. The most prominent radiological findings that were observed in the remaining patients were areas of consolidation (45.2%), often peripheral with multifocal lesions in 22.6%. Peribronchial thickening was noted on chest radiographs of 14.5% of patients. Pleural effusion was observed only in one patient (age 17 years and 11.5 months), whereas interstitial disease was not observed in any patient. CONCLUSION: In pediatric cases, SARS manifests with nonspecific radiographic features making radiological differentiation difficult, especially from other commonly encountered childhood respiratory viral illnesses causing airspace disease. The radiographic presentation of suspected SARS cases ranged from normal to mild perihilar peribronchial thickening. The radiographic presentations, as expected, were relatively more pronounced in the SARS probable cases.