Asunto(s)
Trióxido de Arsénico/uso terapéutico , Gemtuzumab/uso terapéutico , Leucemia Promielocítica Aguda/tratamiento farmacológico , Recurrencia Local de Neoplasia/prevención & control , Adolescente , Antraciclinas/administración & dosificación , Antraciclinas/uso terapéutico , Antineoplásicos/administración & dosificación , Antineoplásicos/uso terapéutico , Antineoplásicos Inmunológicos/administración & dosificación , Antineoplásicos Inmunológicos/uso terapéutico , Trióxido de Arsénico/administración & dosificación , Estudios de Casos y Controles , Niño , Preescolar , Terapia Combinada , Femenino , Gemtuzumab/administración & dosificación , Trasplante de Células Madre Hematopoyéticas/métodos , Humanos , Italia/epidemiología , Leucemia Promielocítica Aguda/diagnóstico , Leucemia Promielocítica Aguda/epidemiología , Leucemia Promielocítica Aguda/mortalidad , Masculino , Pronóstico , Supervivencia sin Progresión , Inducción de Remisión , Estudios Retrospectivos , Terapia Recuperativa/métodos , Terapia Recuperativa/estadística & datos numéricos , Resultado del Tratamiento , Tretinoina/administración & dosificación , Tretinoina/uso terapéutico , Adulto JovenRESUMEN
A boy affected by autism spectrum disorder was admitted for persistent high fever, without shiver, for two weeks. The boy referred to abdominal pain, in the first week of fever, and to mild anorexia in the last days before admittance to our hospital centre. The father reported that the boy suffered by geophagia and coprophagia and he has been going to a didactical farm (where he has been exposed to several kinds of animals) to improve his neuropsychiatric condition. Blood analysis shows severe eosinophilia and high levels of total IgE, and abdominal echocardiography showed hepatic lesions. Enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) confirmed the suspicion of toxocariasis, linked to the habit of the boy to ingest ground or animal faeces in a didactic farm frequented by the boy. Treatment with albendazole and prednisone was administered with a rapid improvement of the symptoms and the laboratory findings and significant reduction of the hepatic lesion.
Asunto(s)
Dolor Abdominal/etiología , Trastorno del Espectro Autista , Fiebre/etiología , Toxocariasis/diagnóstico , Albendazol/uso terapéutico , Animales , Enfermedades de los Gatos , Gatos , Niño , Enfermedades de los Perros , Perros , Ensayo de Inmunoadsorción Enzimática , Humanos , Inmunoglobulina E/sangre , Prednisona/uso terapéutico , Toxocariasis/tratamiento farmacológico , Resultado del TratamientoRESUMEN
We retrospectively analyzed etiological, pathological and clinical features of the patients with hemolytic uremic syndrome (HUS) observed in the Pediatric Nephrology Unit at AOU Meyer of Florence. From January 1997 to December 2008, 22 cases were identified, with an annual incidence of 0.05 cases per 100,000 inhabitants, and 0.34 cases per 100,000 children <15 years old. 60% of the patients were D+ and 40% were D-, with an age distribution from 12 days to 13 years. Twenty patients (90%) had oligoanuria, lasting 6.4 ± 4 days for D+ patients versus 11.8 ± 4 days for D- patients. The development of chronic kidney disease positively correlates with the initial blood pressure value, the length of oligoanuria, and hospitalization. Microbiological investigations showed an association of D+HUS with different strains of Shiga toxin-producing Escherichia coli in 54% of the cases. D-HUS was associated with complement factor H deficiency in one patient. In the other cases, the triggering factors were pertussis, urinary tract infections and upper airway infections. While clinical and prognostic features correspond with literature data, in Tuscany the annual incidence is lower, and the percentage of D-HUS patients is higher than that observed in other studies.