RESUMEN
Half an hour after reperfusion, the kidney, transplanted to the infant from an adult brain dead standard criteria donor, became flabby and acquired blue color. Hyperacute rejection was suspected as a consequence of false negative cross match, and eculizumab was administered with the purpose to treat antibody-mediated injury, with fast and clear effect. The patient's blood was tested for donor-specific antibodies on the next day, and results were negative. We attribute graft damage to reperfusion injury and explain eculizumab's effectiveness to its ability to prevent progression of reperfusion injury.
Asunto(s)
Anticuerpos Monoclonales Humanizados/uso terapéutico , Trasplante de Riñón/efectos adversos , Daño por Reperfusión/terapia , Adulto , Anticuerpos/química , Rechazo de Injerto , Humanos , Lactante , Riñón/patología , Masculino , Daño por Reperfusión/etiología , Bazo/patología , Donantes de TejidosRESUMEN
The critical pathway of deceased donation provides a systematic approach to the organ donation process, considering both donation after cardiac death than donation after brain death. The pathway provides a tool for assessing the potential of deceased donation and for the prospective identification and referral of possible deceased donors.