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1.

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.

Logan, Todd; Simon, Matthew J; Rana, Anil; Cherf, Gerald M; Srivastava, Ankita; Davis, Sonnet S; Low, Ray Lieh Yoon; Chiu, Chi-Lu; Fang, Meng; Huang, Fen; Bhalla, Akhil; Llapashtica, Ceyda; Prorok, Rachel; Pizzo, Michelle E; Calvert, Meredith E K; Sun, Elizabeth W; Hsiao-Nakamoto, Jennifer; Rajendra, Yashas; Lexa, Katrina W; Srivastava, Devendra B; van Lengerich, Bettina; Wang, Junhua; Robles-Colmenares, Yaneth; Kim, Do Jin; Duque, Joseph; Lenser, Melina; Earr, Timothy K; Nguyen, Hoang; Chau, Roni; Tsogtbaatar, Buyankhishig; Ravi, Ritesh; Skuja, Lukas L; Solanoy, Hilda; Rosen, Howard J; Boeve, Bradley F; Boxer, Adam L; Heuer, Hilary W; Dennis, Mark S; Kariolis, Mihalis S; Monroe, Kathryn M; Przybyla, Laralynne; Sanchez, Pascal E; Meisner, Rene; Diaz, Dolores; Henne, Kirk R; Watts, Ryan J; Henry, Anastasia G; Gunasekaran, Kannan; Astarita, Giuseppe; Suh, Jung H.

Cell; 184(18): 4651-4668.e25, 2021 09 02.

Artículo en Inglés | MEDLINE | ID: mdl-34450028

2.

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.

Logan, Todd; Simon, Matthew J; Rana, Anil; Cherf, Gerald M; Srivastava, Ankita; Davis, Sonnet S; Yoon Low, Ray Lieh; Chiu, Chi-Lu; Fang, Meng; Huang, Fen; Bhalla, Akhil; Llapashtica, Ceyda; Prorok, Rachel; Pizzo, Michelle E; Calvert, Meredith E K; Sun, Elizabeth W; Hsiao-Nakamoto, Jennifer; Rajendra, Yashas; Lexa, Katrina W; Srivastava, Devendra B; van Lengerich, Bettina; Wang, Junhua; Robles-Colmenares, Yaneth; Kim, Do Jin; Duque, Joseph; Lenser, Melina; Earr, Timothy K; Nguyen, Hoang; Chau, Roni; Tsogtbaatar, Buyankhishig; Ravi, Ritesh; Skuja, Lukas L; Solanoy, Hilda; Rosen, Howard J; Boeve, Bradley F; Boxer, Adam L; Heuer, Hilary W; Dennis, Mark S; Kariolis, Mihalis S; Monroe, Kathryn M; Przybyla, Laralynne; Sanchez, Pascal E; Meisner, Rene; Diaz, Dolores; Henne, Kirk R; Watts, Ryan J; Henry, Anastasia G; Gunasekaran, Kannan; Astarita, Giuseppe; Suh, Jung H.

Cell; 187(6): 1565-1566, 2024 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-38490183

3.

Cleaning crew: Soluble TREM2 mops up complement.

Monroe, Kathryn M; Lewcock, Joseph W.

Immunity; 56(8): 1701-1703, 2023 08 08.

Artículo en Inglés | MEDLINE | ID: mdl-37557076

4.

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.

Reifschneider, Anika; Robinson, Sophie; van Lengerich, Bettina; Gnörich, Johannes; Logan, Todd; Heindl, Steffanie; Vogt, Miriam A; Weidinger, Endy; Riedl, Lina; Wind, Karin; Zatcepin, Artem; Pesämaa, Ida; Haberl, Sophie; Nuscher, Brigitte; Kleinberger, Gernot; Klimmt, Julien; Götzl, Julia K; Liesz, Arthur; Bürger, Katharina; Brendel, Matthias; Levin, Johannes; Diehl-Schmid, Janine; Suh, Jung; Di Paolo, Gilbert; Lewcock, Joseph W; Monroe, Kathryn M; Paquet, Dominik; Capell, Anja; Haass, Christian.

EMBO J; 41(4): e109108, 2022 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-35019161

5.

NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

Allen, Irving C; Moore, Chris B; Schneider, Monika; Lei, Yu; Davis, Beckley K; Scull, Margaret A; Gris, Denis; Roney, Kelly E; Zimmermann, Albert G; Bowzard, John B; Ranjan, Priya; Monroe, Kathryn M; Pickles, Raymond J; Sambhara, Suryaprakash; Ting, Jenny P Y.

Immunity; 34(6): 854-65, 2011 Jun 24.

Artículo en Inglés | MEDLINE | ID: mdl-21703540

6.

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.

Doitsh, Gilad; Galloway, Nicole L K; Geng, Xin; Yang, Zhiyuan; Monroe, Kathryn M; Zepeda, Orlando; Hunt, Peter W; Hatano, Hiroyu; Sowinski, Stefanie; Muñoz-Arias, Isa; Greene, Warner C.

Nature; 505(7484): 509-14, 2014 Jan 23.

Artículo en Inglés | MEDLINE | ID: mdl-24356306

7.

Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.

Doitsh, Gilad; Galloway, Nicole L K; Geng, Xin; Yang, Zhiyuan; Monroe, Kathryn M; Zepeda, Orlando; Hunt, Peter W; Hatano, Hiroyu; Sowinski, Stefanie; Muñoz-Arias, Isa; Greene, Warner C.

Nature; 544(7648): 124, 2017 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-28329768

8.

STING is a direct innate immune sensor of cyclic di-GMP.

Burdette, Dara L; Monroe, Kathryn M; Sotelo-Troha, Katia; Iwig, Jeff S; Eckert, Barbara; Hyodo, Mamoru; Hayakawa, Yoshihiro; Vance, Russell E.

Nature; 478(7370): 515-8, 2011 Sep 25.

Artículo en Inglés | MEDLINE | ID: mdl-21947006

9.

Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.

Humphreys, Gregory B; Jud, Molly C; Monroe, Kathryn M; Kimball, Suzanne S; Higley, Matthew; Shipley, Danielle; Vrablik, Marie Clougherty; Bates, Katherine L; Letsou, Anthea.

Dev Biol; 381(2): 434-45, 2013 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-23796903

10.

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer, John-Demian; Sotelo-Troha, Katia; von Moltke, Jakob; Monroe, Kathryn M; Rae, Chris S; Brubaker, Sky W; Hyodo, Mamoru; Hayakawa, Yoshihiro; Woodward, Joshua J; Portnoy, Daniel A; Vance, Russell E.

Infect Immun; 79(2): 688-94, 2011 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-21098106

11.

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila.

Monroe, Kathryn M; McWhirter, Sarah M; Vance, Russell E.

PLoS Pathog; 5(11): e1000665, 2009 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-19936053

12.

Induction of type I interferons by bacteria.

Monroe, Kathryn M; McWhirter, Sarah M; Vance, Russell E.

Cell Microbiol; 12(7): 881-90, 2010 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-20482555

13.

Diet-dependent regulation of TGFß impairs reparative innate immune responses after demyelination.

Bosch-Queralt, Mar; Cantuti-Castelvetri, Ludovico; Damkou, Alkmini; Schifferer, Martina; Schlepckow, Kai; Alexopoulos, Ioannis; Lütjohann, Dieter; Klose, Christian; Vaculciaková, Lenka; Masuda, Takahiro; Prinz, Marco; Monroe, Kathryn M; Di Paolo, Gilbert; Lewcock, Joseph W; Haass, Christian; Simons, Mikael.

Nat Metab; 3(2): 211-227, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33619376

14.

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.

Lewcock, Joseph W; Schlepckow, Kai; Di Paolo, Gilbert; Tahirovic, Sabina; Monroe, Kathryn M; Haass, Christian.

Neuron; 108(5): 801-821, 2020 12 09.

Artículo en Inglés | MEDLINE | ID: mdl-33096024

15.

Alzheimer's-associated PLCÎ³2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.

Andreone, Benjamin J; Przybyla, Laralynne; Llapashtica, Ceyda; Rana, Anil; Davis, Sonnet S; van Lengerich, Bettina; Lin, Karin; Shi, Ju; Mei, Yuan; Astarita, Giuseppe; Di Paolo, Gilbert; Sandmann, Thomas; Monroe, Kathryn M; Lewcock, Joseph W.

Nat Neurosci; 23(8): 927-938, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32514138

16.

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.

Schlepckow, Kai; Monroe, Kathryn M; Kleinberger, Gernot; Cantuti-Castelvetri, Ludovico; Parhizkar, Samira; Xia, Dan; Willem, Michael; Werner, Georg; Pettkus, Nadine; Brunner, Bettina; Sülzen, Alice; Nuscher, Brigitte; Hampel, Heike; Xiang, Xianyuan; Feederle, Regina; Tahirovic, Sabina; Park, Joshua I; Prorok, Rachel; Mahon, Cathal; Liang, Chun-Chi; Shi, Ju; Kim, Do Jin; Sabelström, Hanna; Huang, Fen; Di Paolo, Gilbert; Simons, Mikael; Lewcock, Joseph W; Haass, Christian.

EMBO Mol Med; 12(4): e11227, 2020 04 07.

Artículo en Inglés | MEDLINE | ID: mdl-32154671

17.

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

Nugent, Alicia A; Lin, Karin; van Lengerich, Bettina; Lianoglou, Steve; Przybyla, Laralynne; Davis, Sonnet S; Llapashtica, Ceyda; Wang, Junhua; Kim, Do Jin; Xia, Dan; Lucas, Anthony; Baskaran, Sulochanadevi; Haddick, Patrick C G; Lenser, Melina; Earr, Timothy K; Shi, Ju; Dugas, Jason C; Andreone, Benjamin J; Logan, Todd; Solanoy, Hilda O; Chen, Hang; Srivastava, Ankita; Poda, Suresh B; Sanchez, Pascal E; Watts, Ryan J; Sandmann, Thomas; Astarita, Giuseppe; Lewcock, Joseph W; Monroe, Kathryn M; Di Paolo, Gilbert.

Neuron; 105(5): 837-854.e9, 2020 03 04.

Artículo en Inglés | MEDLINE | ID: mdl-31902528

18.

Author Correction: Diet-dependent regulation of TGFß impairs reparative innate immune responses after demyelination.

Bosch-Queralt, Mar; Cantuti-Castelvetri, Ludovico; Damkou, Alkmini; Schifferer, Martina; Schlepckow, Kai; Alexopoulos, Ioannis; Lütjohann, Dieter; Klose, Christian; Vaculciaková, Lenka; Masuda, Takahiro; Prinz, Marco; Monroe, Kathryn M; Di Paolo, Gilbert; Lewcock, Joseph W; Haass, Christian; Simons, Mikael.

Nat Metab; 5(3): 531, 2023 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-36823473

19.

Microglia clean up toxic lipids in multiple sclerosis.

Monroe, Kathryn M; Di Paolo, Gilbert.

Nat Neurosci; 24(4): 451-452, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33758401

20.

Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells.

Galloway, Nicole Lk; Doitsh, Gilad; Monroe, Kathryn M; Yang, Zhiyuan; Muñoz-Arias, Isa; Levy, David N; Greene, Warner C.

Cell Rep; 12(10): 1555-1563, 2015 Sep 08.

Artículo en Inglés | MEDLINE | ID: mdl-26321639

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.

Cleaning crew: Soluble TREM2 mops up complement.

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.

NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.

Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.

STING is a direct innate immune sensor of cyclic di-GMP.

Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila.

Induction of type I interferons by bacteria.

Diet-dependent regulation of TGFß impairs reparative innate immune responses after demyelination.

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.

Alzheimer's-associated PLCÎ³2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

Author Correction: Diet-dependent regulation of TGFß impairs reparative innate immune responses after demyelination.

Microglia clean up toxic lipids in multiple sclerosis.

Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells.