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1.
Semin Dial ; 37(3): 228-233, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38099410

RESUMEN

BACKGROUND: The nutritional status of incident patients on peritoneal dialysis (PD) has been associated with survival outcomes. Bioimpedanciometry (BCM) enables to establish a nutritional diagnosis, the volume status, and correlates these findings with survival. METHODS: This study used a retrospective multicenter historical cohort. RESULTS: In this study, which included 420 incident patients on peritoneal dialysis with a 5-year follow-up, a cumulative incidence of major adverse cardiovascular events (MACE) of 28.8% was found, being higher in the diabetic population at 36.8%. In regard to the nutritional status in this population, it was found that approximately 44% had altered nutritional status; 34% were found to be in sarcopenia; 6.7% sarcopenic obesity; and 2.8% in obesity (p < 0.001). In the survival analysis, a lower probability of survival was found in patients with overhydration (OH) greater than 3 L (p < 0.001) and in patients with altered nutritional status due to sarcopenia, sarcopenic obesity, and obesity (p 0.016). According to survival in the subgroup of the diabetic population, a lower probability of survival was found in this group of patients (p: 0.011). The overall mortality of the study population was 18%, being higher in the first 2 years, with the most important causes of mortality being cardiovascular. Of the deceased population, 51% were diabetic patients (p: 0.012). CONCLUSION: In incident patients on peritoneal dialysis, sarcopenic obesity, sarcopenia, overhydration status determined by BCM, and having a diagnosis of diabetes are related to a lower probability of survival; MACE outcomes are more frequent in the diabetic population.


Asunto(s)
Enfermedades Cardiovasculares , Fallo Renal Crónico , Estado Nutricional , Diálisis Peritoneal , Humanos , Masculino , Femenino , Enfermedades Cardiovasculares/mortalidad , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/etiología , Persona de Mediana Edad , Estudios Retrospectivos , Incidencia , Fallo Renal Crónico/terapia , Fallo Renal Crónico/mortalidad , Fallo Renal Crónico/complicaciones , Colombia/epidemiología , Anciano , Adulto , Tasa de Supervivencia , Sarcopenia/epidemiología , Sarcopenia/diagnóstico , Sarcopenia/mortalidad , Sarcopenia/etiología
2.
Photochem Photobiol Sci ; 22(2): 319-331, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36269518

RESUMEN

The native forest of northwestern Argentina, as part of the Chaco region, is a rich and unexploited source of phytochemical compounds for medicinal/cosmetic applications. In the present study, fruit, leaf, branch, and bark organs of the native trees Sarcomphalus mistol (Mistol, M) and Schinopsis lorentzii (Quebracho Colorado santiagueño, QC) were harvested, and aqueous plant extracts (PE) were prepared. The spectroscopic (UV-Vis absorbance, diffuse reflectance, ATR-FTIR) and antioxidant (TEAC, Folin-Ciocalteu) properties of PE were characterized and used as TiO2 coating material to obtain a series of TiO2@PE nanocomposites. These materials showed almost null photocatalytic activity compared to aqueous suspensions of bare TiO2, displaying yellowish to brownish coloration and high long-term stability in both freshwater and seawater model solutions. The loss of photocatalytic activity in TiO2@PE was associated with the combination of the internal filter effect and the antioxidant/radical capacity exerted by the phytochemicals of the PE coating, with higher broadband photoprotection for the nanocomposites prepared with QC extracts. Thus, this study shows the potential capacity of the forest resources of the Chaco region of Argentina for the development of new cosmetic and/or sun protection formulations.

3.
J Craniofac Surg ; 34(3): 1082-1084, 2023 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-36036489

RESUMEN

Measurements from a certain population may show a similar pattern that allows an alteration to be easily recognized and enable a better surgical approach. In our population, the changes in the anthropometric measurements of the lips are unknown, so our objective is to determine the variations in these measurements by decades of age to achieve a better aesthetic and reconstructive surgical approach. Anthropometric measurements of the lips were taken with a vernier in relation to the previously marked anatomical points. The sample consists of 174 patients who came for care not related to labial pathologies with ages between 20 and 80 years with Mexican nationality. We use the sample calculation formula to estimate an average, with an alpha error of 0.5 and a tolerance of 2 mm of the data for the measurements of the height of the lower face with an average measurement of 56.2 mm and a SD of 8.87 mm of the Marzena's article. Wyganowska-Swiatkowska and colleagues Average measurements were obtained, where a progressive longitudinal increase in measures: al-ch, sbl-cph, sn-Is, li-sto, cph-Is, li-sl, ch-li, li-pg according to aging is confirmed. In contrast, the ch-cph and ch-sbl measures, remain the same despite the aging, showing greater changes in the sagittal plane than in the parasagittal. The study only shows measures of length, so caring out a magnetic resonance imaging study to also measure the volume and perform it with a larger sample to have the optimal standard is further needed.


Asunto(s)
Cara , Labio , Humanos , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Cara/anatomía & histología , Estética Dental , Procesamiento de Imagen Asistido por Computador , Antropometría
4.
Sensors (Basel) ; 23(6)2023 Mar 18.
Artículo en Inglés | MEDLINE | ID: mdl-36991950

RESUMEN

This paper presents the use of deep Reinforcement Learning (RL) for autonomous navigation of an Unmanned Ground Vehicle (UGV) with an onboard three-dimensional (3D) Light Detection and Ranging (LiDAR) sensor in off-road environments. For training, both the robotic simulator Gazebo and the Curriculum Learning paradigm are applied. Furthermore, an Actor-Critic Neural Network (NN) scheme is chosen with a suitable state and a custom reward function. To employ the 3D LiDAR data as part of the input state of the NNs, a virtual two-dimensional (2D) traversability scanner is developed. The resulting Actor NN has been successfully tested in both real and simulated experiments and favorably compared with a previous reactive navigation approach on the same UGV.

5.
Sensors (Basel) ; 23(2)2023 Jan 11.
Artículo en Inglés | MEDLINE | ID: mdl-36679628

RESUMEN

Interest in Unmanned Aerial Vehicles (UAVs) has increased due to their versatility and variety of applications, however their battery life limits their applications. Heterogeneous multi-robot systems can offer a solution to this limitation, by allowing an Unmanned Ground Vehicle (UGV) to serve as a recharging station for the aerial one. Moreover, cooperation between aerial and terrestrial robots allows them to overcome other individual limitations, such as communication link coverage or accessibility, and to solve highly complex tasks, e.g., environment exploration, infrastructure inspection or search and rescue. This work proposes a vision-based approach that enables an aerial robot to autonomously detect, follow, and land on a mobile ground platform. For this purpose, ArUcO fiducial markers are used to estimate the relative pose between the UAV and UGV by processing RGB images provided by a monocular camera on board the UAV. The pose estimation is fed to a trajectory planner and four decoupled controllers to generate speed set-points relative to the UAV. Using a cascade loop strategy, these set-points are then sent to the UAV autopilot for inner loop control. The proposed solution has been tested both in simulation, with a digital twin of a solar farm using ROS, Gazebo and Ardupilot Software-in-the-Loop (SiL); and in the real world at IST Lisbon's outdoor facilities, with a UAV built on the basis of a DJ550 Hexacopter and a modified Jackal ground robot from DJI and Clearpath Robotics, respectively. Pose estimation, trajectory planning and speed set-point are computed on board the UAV, using a Single Board Computer (SBC) running Ubuntu and ROS, without the need for external infrastructure.


Asunto(s)
Comunicación , Dispositivos Aéreos No Tripulados , Especies Reactivas de Oxígeno , Simulación por Computador , Suministros de Energía Eléctrica
6.
Aten Primaria ; 55(12): 102779, 2023 Dec.
Artículo en Español | MEDLINE | ID: mdl-37804803

RESUMEN

OBJECTIVE: To determine the risk factors associated with disability in patients who had a stroke in northeastern Mexico. DESIGN: This was an observational, retrospective, cross-sectional study. SITE: Conducted at the Family Medicine Unit No. 33 of the Mexican Institute of Social Security in Reynosa, Tamaulipas, Mexico. PARTICIPANTS: One hundred and ninety-eight males and 146 females, above 18 years old, beneficiaries of the Mexican Institute of Social Security with a diagnosis of stroke between 2018 and 2021. INTERVENTIONS: The Barthel index that assesses the degree of dependence to perform basic activities of daily living was applied to the participants and sociodemographic, biological and anthropometric variables were collected from the digital medical record. MAIN MEASURES: A univariate, correlational and ordinal logistic regression statistical analysis was performed between independent and dependent variables to obtain measures of frequency, percentages, and associated risks. RESULTS: The risk factors associated with disability were age (OR 1.03, CI 1.01-1.05), overweight (OR 1.81, CI 1.03-3.1), obesity grade I (OR 2.74, CI 1.46-5.1), obesity grade II (OR 4.38, CI 1.44-13), obesity grade III (OR 9.99, CI 2.12-47); type of stroke: ischemic (OR 4.60, CI 2.6-8) or thrombotic (OR 4.95, CI 1.57-15). The number of comorbidities was associated with disability when having one comorbidity (OR 2.80, CI 1.22-6.4), two comorbidities (OR 3.43, CI 1.37-8.5), three comorbidities (OR 2.71, CI 1.01-7.3), and with five comorbidities (OR 3.17, CI 1.01-9.9). CONCLUSIONS: The risk factors found for disability were age, overweight, obesity, and type of ischemic and thrombotic stroke. Being cared for by a relative and/or spouse reduces the probability of disability.


Asunto(s)
Sobrepeso , Accidente Cerebrovascular , Masculino , Femenino , Humanos , Adolescente , Estudios Transversales , Estudios Retrospectivos , México/epidemiología , Sobrepeso/complicaciones , Sobrepeso/epidemiología , Actividades Cotidianas , Factores de Riesgo , Accidente Cerebrovascular/epidemiología , Obesidad/complicaciones , Obesidad/epidemiología
7.
Sensors (Basel) ; 22(15)2022 Jul 26.
Artículo en Inglés | MEDLINE | ID: mdl-35898100

RESUMEN

This paper presents a new synthetic dataset obtained from Gazebo simulations of an Unmanned Ground Vehicle (UGV) moving on different natural environments. To this end, a Husky mobile robot equipped with a tridimensional (3D) Light Detection and Ranging (LiDAR) sensor, a stereo camera, a Global Navigation Satellite System (GNSS) receiver, an Inertial Measurement Unit (IMU) and wheel tachometers has followed several paths using the Robot Operating System (ROS). Both points from LiDAR scans and pixels from camera images, have been automatically labeled into their corresponding object class. For this purpose, unique reflectivity values and flat colors have been assigned to each object present in the modeled environments. As a result, a public dataset, which also includes 3D pose ground-truth, is provided as ROS bag files and as human-readable data. Potential applications include supervised learning and benchmarking for UGV navigation on natural environments. Moreover, to allow researchers to easily modify the dataset or to directly use the simulations, the required code has also been released.


Asunto(s)
Robótica , Benchmarking , Ambiente , Humanos , Especies Reactivas de Oxígeno , Programas Informáticos
8.
Minim Invasive Ther Allied Technol ; 31(7): 1058-1065, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35913784

RESUMEN

INTRODUCTION: We performed an analysis of two blood purification systems to determine their performance for removing interleukins (ILs)-6 and 10, tumor necrosis factor (TNF)-α and monocyte chemoattractant protein (MCP)-1 from blood. MATERIAL AND METHODS: An in vitro hemoperfusion blood recirculation circuit was used to compare the CytoSorb® 300 mL (CytoSorbents Inc., Princeton, NJ) and Jafron HA 380 (Jafron Biomedical Co., Ltd., Zhuhai City, China) devices. The removal of purified recombinant human IL-6, IL-10, TNFα and MCP-1 by the adsorbers was compared at various timepoints. Three runs were completed and removal was evaluated as the mean area under the curve (AUC). RESULTS: Both devices showed effective removal of the tested cytokines. IL-6, IL-10, TNFα and MCP-1 were removed faster and to a higher extent by the CytoSorb® 300 mL device. At maximal time of 12 h, overall removal according to AUC of remaining concentrations was significantly lower with CytoSorb® 300 mL compared with HA 380 (IL-6: 1075.5 ± 665.9 vs. 4345.1 ± 1499.3 (p = 0.01), IL-10: 5065.7 ± 882.5 vs. 11,939.7 ± 4523.1 (p = 0.03), TNF-α: 6519.9 ± 997.6 vs. 10,303.7 ± 2347.0 (p = 0.03) and MCP-1: 278.9 ± 40.7 vs. 607.3 ± 84.4 (p = 0.001)). CONCLUSIONS: Both the CytoSorb® and the Jafron HA 380 devices are capable of removing cytokines from blood in a benchtop model. The CytoSorb® 300 device was significantly more efficient achieving the bulk of the removal in the first 120 min.


Asunto(s)
Hemoperfusión , Interleucina-10 , Citocinas , Humanos , Interleucina-6 , Factor de Necrosis Tumoral alfa
9.
Sensors (Basel) ; 21(17)2021 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-34502744

RESUMEN

This paper proposes a low-cost sensor system composed of four GNSS-RTK receivers to obtain accurate position and posture estimations for a vehicle in real-time. The four antennas of the receivers are placed so that every three-antennas combination is optimal to get the most precise 3D coordinates with respect to a global reference system. The redundancy provided by the fourth receiver allows to improve estimations even more and to maintain accuracy when one of the receivers fails. A mini computer with the Robotic Operating System is responsible for merging all the available measurements reliably. Successful experiments have been carried out with a ground rover on irregular terrain. Angular estimates similar to those of a high-performance IMU have been achieved in dynamic tests.


Asunto(s)
Robótica , Programas Informáticos , Postura
10.
Sensors (Basel) ; 20(22)2020 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-33182808

RESUMEN

Reactivity is a key component for autonomous vehicles navigating on natural terrains in order to safely avoid unknown obstacles. To this end, it is necessary to continuously assess traversability by processing on-board sensor data. This paper describes the case study of mobile robot Andabata that classifies traversable points from 3D laser scans acquired in motion of its vicinity to build 2D local traversability maps. Realistic robotic simulations with Gazebo were employed to appropriately adjust reactive behaviors. As a result, successful navigation tests with Andabata using the robot operating system (ROS) were performed on natural environments at low speeds.

11.
Sensors (Basel) ; 18(2)2018 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-29385705

RESUMEN

Multi-beam lidar (MBL) rangefinders are becoming increasingly compact, light, and accessible 3D sensors, but they offer limited vertical resolution and field of view. The addition of a degree-of-freedom to build a rotating multi-beam lidar (RMBL) has the potential to become a common solution for affordable rapid full-3D high resolution scans. However, the overlapping of multiple-beams caused by rotation yields scanning patterns that are more complex than in rotating single beam lidar (RSBL). In this paper, we propose a simulation-based methodology to analyze 3D scanning patterns which is applied to investigate the scan measurement distribution produced by the RMBL configuration. With this purpose, novel contributions include: (i) the adaption of a recent spherical reformulation of Ripley's K function to assess 3D sensor data distribution on a hollow sphere simulation; (ii) a comparison, both qualitative and quantitative, between scan patterns produced by an ideal RMBL based on a Velodyne VLP-16 (Puck) and those of other 3D scan alternatives (i.e., rotating 2D lidar and MBL); and (iii) a new RMBL implementation consisting of a portable tilting platform for VLP-16 scanners, which is presented as a case study for measurement distribution analysis as well as for the discussion of actual scans from representative environments. Results indicate that despite the particular sampling patterns given by a RMBL, its homogeneity even improves that of an equivalent RSBL.

12.
Sensors (Basel) ; 14(11): 20025-40, 2014 Oct 24.
Artículo en Inglés | MEDLINE | ID: mdl-25347585

RESUMEN

Many applications, like mobile robotics, can profit from acquiring dense, wide-ranging and accurate 3D laser data. Off-the-shelf 2D scanners are commonly customized with an extra rotation as a low-cost, lightweight and low-power-demanding solution. Moreover, aligning the extra rotation axis with the optical center allows the 3D device to maintain the same minimum range as the 2D scanner and avoids offsets in computing Cartesian coordinates. The paper proposes a practical procedure to estimate construction misalignments based on a single scan taken from an arbitrary position in an unprepared environment that contains planar surfaces of unknown dimensions. Inherited measurement limitations from low-cost 2D devices prevent the estimation of very small translation misalignments, so the calibration problem reduces to obtaining boresight parameters. The distinctive approach with respect to previous plane-based intrinsic calibration techniques is the iterative maximization of both the flatness and the area of visible planes. Calibration results are presented for a case study. The method is currently being applied as the final stage in the production of a commercial 3D rangefinder.

13.
Sensors (Basel) ; 13(4): 4485-98, 2013 Apr 03.
Artículo en Inglés | MEDLINE | ID: mdl-23552102

RESUMEN

Driving vehicles with one or more passive trailers has difficulties in both forward and backward motion due to inter-unit collisions, jackknife, and lack of visibility. Consequently, advanced driver assistance systems (ADAS) for multi-trailer combinations can be beneficial to accident avoidance as well as to driver comfort. The ADAS proposed in this paper aims to prevent unsafe steering commands by means of a haptic handwheel. Furthermore, when driving in reverse, the steering-wheel and pedals can be used as if the vehicle was driven from the back of the last trailer with visual aid from a rear-view camera. This solution, which can be implemented in drive-by-wire vehicles with hitch angle sensors, profits from two methods previously developed by the authors: safe steering by applying a curvature limitation to the leading unit, and a virtual tractor concept for backward motion that includes the complex case of set-point propagation through on-axle hitches. The paper addresses system requirements and provides implementation details to tele-operate two different off- and on-axle combinations of a tracked mobile robot pulling and pushing two dissimilar trailers.


Asunto(s)
Algoritmos , Conducción de Automóvil , Vehículos a Motor , Humanos , Movimiento (Física)
14.
ISA Trans ; 139: 524-547, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37210264

RESUMEN

This paper proposes an adaptive sensorless control based on sliding mode approach for Interior Permanent Magnet Synchronous Motor (IPMSM) using the method of the angular position estimation error extraction. The proposed strategy combines a novel Adaptive Super-Twisting Controller (ASTWC) with a novel Adaptive Observer High-Order Sliding Mode (AOHOSM), where: (i) The control and observer gains are parameterized in terms of a single parameter simplifying its implementation and reducing the tuning time. (ii) By using an auxiliary system, which does not depend on machine parameters, an AOHOSM is designed for estimating the angular position, speed and acceleration in a wide speed range of the IPMSM, (iii) and these are used in an ASTWC to track a desired reference of speed and direct-axis current. (iv) Sufficient conditions are given to ensure the stability of the closed-loop system using a Lyapunov approach. Furthermore, the proposed strategy is validated throughout experimental set-up in order to show its effectiveness. Finally, a comparative study between the proposed strategy and other strategies published in the literature is addressed.

15.
ISA Trans ; 139: 561-573, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37142492

RESUMEN

A novel adaptive super-twisting control algorithm, for Unmanned Surface Vehicles (USV) tracking control is presented. The proposed adaptive law is obtained using a Lyapunov approach, to analyze the system closed-loop stability. Furthermore, several conditions are given to guarantee robustness in presence of unknown bounded disturbances/uncertainties, chattering mitigation and the finite-time convergence. This adaptive control strategy has the advantage that the controller gains, which are in terms of a single control parameter, requires adjusting a small number of parameters compared with other adaptive strategies, moreover and its dynamics is smooth, improving the controller performance. To assess the proposed control methodology effectiveness, a trajectory tracking control is designed and implemented on an unmanned surface vehicle under the action of bounded unknown uncertainties and external perturbations. Numerical simulations and experimental results conducted with a vessel prototype demonstrate the performance and advantages under payload variations and external environmental conditions. Finally, a comparative study between the proposed approach with other adaptive super-twisting works has been conducted.

16.
Environ Sci Pollut Res Int ; 30(56): 118536-118544, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37917255

RESUMEN

Ketorolac, a highly persistent NSAID of environmental concern, was significantly removed from water (80% removal) through photoelectrocatalysis where titanium dioxide nanotubes prepared by Ti foil electrochemical anodization at 30 V were used as photoanodes. Fifteen milligrams per liter of ketorolac solutions in a 0.05 M Na2SO4 aqueous medium was subjected to irradiation from a 365-nm light with an intensity of 1 mWcm-2 and under an applied potential of 1.3 V (vs. Hg/Hg2SO4/sat.K2SO4) at pH 6.0. When each process (photo and electrocatalysis) was carried out separately, less than 20% drug removal was achieved as monitored through UV-vis spectrophotometry. Through scavenging experiments, direct oxidation on the photogenerated holes and oxidation by hydroxyl radical formation were found to play a key role on ketorolac's degradation. Chemical oxygen demand (COD) analyses also showed a significant COD decreased (68%) since the initial COD value was 31.3 mg O2/L and the final COD value was 10.1 mg O2/L. A 48% mineralization was also achieved, as shown by total organic carbon (TOC) analyses. These results showed that electrodes based on titania nanotubes are a promising alternative material for simultaneous photocatalytic and electrocatalytic processes in water remediation.


Asunto(s)
Mercurio , Nanotubos , Contaminantes Químicos del Agua , Agua , Ketorolaco , Titanio , Oxidación-Reducción , Electrodos , Catálisis
17.
Patient Educ Couns ; 110: 107656, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-36807126

RESUMEN

BACKGROUND: The treatment of schizophrenia requires a prolonged, multidimensional intervention that includes antipsychotic drugs. Treatment adherence is essential to effectively control the disorder. Shared decision-making (SDM) is a strategy, supported by numerous practical and ethical arguments, that seeks to involve patients in the therapeutic process to improve treatment adherence and satisfaction. The use of this model in mental health has been limited for many intrinsic and extrinsic reasons. The results of clinical trials conducted to date have largely been disappointing, potential due to study design-related limitations. AIM/QUESTION: To evaluate the efficacy, in terms of treatment adherence and improvement in clinical variables, such as severity of symptoms, days of hospitalization or insight, of a carefully timed SDM model initiated immediately prior to hospital discharge in patients with schizophrenia. METHODS: Single-blind, randomized clinical trial in an acute psychiatric care unit within the Andalusian Health Department to compare SDM (experimental group) to treatment as usual (TAU; control group) in a sample of patients hospitalized for an acute episode of schizophrenia or schizoaffective disorder. The study was performed between January 2014 and June 2017. The experimental group participated in SDM sessions prior to discharge with regular booster sessions over the one-year follow-up. The health care team responsible for SDM was predisposed to concordance (LatCon II scale) and received specific training in SDM. A hierarchical multiple linear regression analysis was performed to evaluate the factors independently associated with adherence, controlling for sociodemographic, clinical, and admission-related variables. Variables were assessed at admission, discharge and at 3, 6 and 12 months after discharge during the one year follow up. BARS, DAI, WAI-S, COMRADE and PANSS were used to evaluate adherence, attitude to treatment, therapeutic alliance, satisfaction and confidence with decision and clinical status, respectively. RESULTS: A total of 227 schizophrenic patients hospitalized with acute decompensation were evaluated; of these, 102 met all inclusion criteria and were included in the study. Most patients (95%) had prior experience with antipsychotics and most (82%) had experienced related side effects. Despite randomization, psychopathologic severity was greater in the experimental group, with a mean (SD) PANSS score of 104.08 (80) vs. 93.45 (20.30) (p < 0.05). The final regression model to explain adherence was significant (adjusted R2 = 0.384; F [df= 6] = 4.386; p < 0.001), with a direct, significant and independent association with SDM mediated by the number of booster sessions. DISCUSSION: Shared decision making with booster sessions appears to increase treatment adherence in patients with severe mental disorders. IMPLICATION ON PRACTICE: Ethical, practical, and clinical reasons support the use of strategies designed promote the use of long-term, shared decision-making in psychiatric patients, especially in schizophrenia spectrum disorder.


Asunto(s)
Antipsicóticos , Esquizofrenia , Humanos , Toma de Decisiones Conjunta , Método Simple Ciego , Esquizofrenia/tratamiento farmacológico , Antipsicóticos/uso terapéutico , Pacientes , Toma de Decisiones , Participación del Paciente
18.
Eur Heart J Cardiovasc Pharmacother ; 8(8): 847-856, 2022 12 02.
Artículo en Inglés | MEDLINE | ID: mdl-35657375

RESUMEN

AIM: To evaluate the ability of the DrugSorb™-AntiThrombotic Removal (ATR) haemoadsorption device utilizing porous polymer bead sorbent technology to remove three commonly used antithrombotic drugs from whole blood. METHODS AND RESULTS: We evaluated the removal of apixaban, rivaroxaban, and ticagrelor by the DrugSorb-ATR haemoadsorption device in a benchtop clinical scale model using bovine whole blood. Blood spiked at clinically relevant concentrations of an antithrombotic agent was continuously circulated through a 300-mL DrugSorb-ATR haemoadsorption device at a flow rate of 300 mL/min. Drug concentration was monitored over 6 h to evaluate drug removal. Results were compared with a control circuit without the haemoadsorption device. Removal rates at 30, 60, 120, and 360 minutes were: apixaban: 81.5%, 96.3%, 99.3% >99.8%; rivaroxaban: 80.7%, 95.1%, 98.9%, >99.5%; ticagrelor: 62.5%; 75%, 86.6%, >95% (all P <0.0001 vs. control). Blood pH and haematological parameters were not significantly affected by the DrugSorb-ATR haemoadsorption device when compared with the control circuit. CONCLUSION: DrugSorb-ATR efficiently removes apixaban, rivaroxaban, and ticagrelor in a clinical-scale benchtop recirculation circuit with the bulk of removal occurring in the first 60 minutes. The clinical implications of these findings are currently investigated in patients undergoing on-pump cardiothoracic surgery in two US pivotal trials (ClinicalTrials.gov Identifiers: NCT04976530 and NCT05093504).


Asunto(s)
Fibrinolíticos , Rivaroxabán , Animales , Bovinos , Humanos , Polímeros , Porosidad , Ticagrelor , Ensayos Clínicos como Asunto
19.
Photochem Photobiol ; 97(1): 22-31, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32762117

RESUMEN

A set of opaque films were prepared with Degussa P25® or Hombikat UV100® TiO2 powders by the doctor blade method on glass slides with different compositions of polyethylene glycol of 20 kDa (PEG20), and they were characterized by spectroscopy, microscopy and photochemical kinetics measurements. After annealing treatment at 450 °C, about 5-7% C atom was incorporated into the films, as a consequence of the degradation of the organic complexing agents, inducing a small reduction of the energy band gap of TiO2 (i.e. 3.02 ≤ Eg (eV) ≤ 3.08). All films were about 15 ± 2 µm thick but their micro-morphological characteristics depended on the content of PEG20, showing different patterns of cracks and aggregates that produce intense light scattering and retransmission phenomena with the result of a three-dimensional excitation of the TiO2 particles in the thick film. Back-face excitation with UVA light (365 ± 42 nm) of the opaque films in contact with an aqueous solution produced both surface-bound and free hydroxyl radicals (HO• ), as detected using a coumarin solution as a radical dosimeter. The photogeneration efficiency of HO• decreased with the surface roughness of the films, which varied between 135 and 439 nm depending on the film's composition.

20.
ISA Trans ; 112: 99-107, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33353752

RESUMEN

In this paper, simultaneous state estimation and parameters identification for a class of nonlinear systems are addressed. With the aim of solving this problem, an adaptive observer based on the sliding mode (AOSM) approach is designed. The main advantage of the proposed adaptive observer design is that it combines the robustness and finite time convergence of the sliding mode observers, with the simplicity of tuning of high-gain observers, reducing tuning effort. The finite time convergence of the proposed adaptive observer is established using a Lyapunov approach. Furthermore, a comparative study of the proposed adaptive observer against schemes from literature is presented, in order to show the advantages of the proposed approach. Finally, numerical results are provided to demonstrate the effectiveness and performance of the proposed approach under noise and external disturbances.

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