Acetazolamide Intoxication in an Elderly Patient with Diabetes and Chronic Renal Failure after Cataract Surgery.

Carbonic anhydrase inhibitors, such as acetazolamide, are widely used in the treatment of open-angle glaucoma. Severe metabolic acidosis is a rare complication of acetazolamide use, and life-threatening acidosis occurs most commonly in elderly patients, in patients with advanced renal failure, and in patients with diabetes. We describe an unusual case of an elderly patient with diabetic nephropathy and chronic renal failure who presented to the emergency department with severe metabolic acidosis and coma after exposure to high doses of acetazolamide in the postoperative period of ophthalmic surgery. As symptoms of acetazolamide intoxication and uremia are similar, high suspicion is required to detect excessive plasma drug concentrations and intoxication in patients presenting with concomitant uremia. Clinical symptoms are potentially reversible with prompt diagnosis and treatment, including supportive treatment, bicarbonate therapy, and renal replacement therapy. Hemodialysis is particularly helpful in the management of acetazolamide overdose as the medication is dialyzable.

Anticoagulant-related nephropathy: systematic review and meta-analysis.

BACKGROUND: The aim of this study was to report the prevalence and mortality associated with anticoagulant-related nephropathy (ARN) through a systematic review of the literature. METHODS: Electronic searches were conducted in the Medline and EMBASE databases, and manual searches were performed in the reference lists of the identified studies. The studies were selected by two independent researchers, first by evaluating the titles and abstracts and then by reading the complete texts of the identified studies. Case series, cross-sectional studies, cohort studies and case-control studies reporting the prevalence and factors associated with ARN were selected. The methodological quality was assessed using the Newcastle-Ottawa scale. Meta-analyses of the prevalence of ARN and 5-year mortality using the random effects model were performed when possible. Heterogeneity was assessed using the I 2 statistic. RESULTS: Five studies were included. Prevalence of ARN ranged from 19% to 63% among the four included cohort studies. Meta-analysis of these resulted in high heterogeneity [I 2 96%, summary effect 31%; 95% confidence interval (CI) 22-42%]. Subgroup meta-analysis yielded an ARN prevalence of 20% among studies that included patients with fewer comorbidities (I 2 12%; 95% CI 19-22%). In a direct comparison, meta-analysis of the 5-year mortality rate between anticoagulated patients who had experienced ARN and anticoagulated patients without ARN, patients with ARN were 91% more likely to die (risk ratio = 1.91; 95% CI 1.22-3; I 2 87%). Risk factors for ARN that were reported in the literature included initial excessive anticoagulation, chronic kidney disease, age, diabetes, hypertension, cardiovascular disease and heart failure. CONCLUSIONS: ARN studies are scarce and heterogeneous, and present significant methodological limitations. The high prevalence of ARN reported herein suggests that this entity is underdiagnosed in clinical practice. Mortality in patients with ARN seems to be high compared with patients without this condition in observational studies.

Motivations for smoking in hospitalized patients.

OBJECTIVE: To investigate the profile of motivations for smoking among inpatients at a hospital in southern Brazil. METHODS: A survey study involving hospitalized smokers. The Modified Reasons for Smoking Scale (MRFSS) and its domains were analyzed according to gender and dependence degree. RESULTS: The sample consisted of 85 adults (mean age 53 years), low schooling/family income, and well-adjusted in terms of gender (male= 52.9%) and clinical (48%) or surgical (47%) specialty. Most were in Action as the motivational stage (68%), with elevated smoking exposure (median = 39 years/packs) and dependence degree of nicotine (56.4%). The highest domains of the MRFSS were: Smoking Pleasure (4.34 ± 1.2), Relaxation/Tension Reduction (4.24 ± 1.2) and Dependence (3.8±1.4). Significantly, women presented higher scores, in domain Relaxation/Tension Reduction (4.7±0.9). In those with elevated nicotine dependence, higher scores were observed in the Automatism/Habit and Stimulation domains. CONCLUSIONS: Smoking Pleasure and Relaxation/Tension Reduction, especially in women and Automatism, in those more dependents, are factors that should be more highlighted in future strategies for smoking cessation in inpatients.

Motivations for smoking in hospitalized patients

SUMMARY OBJECTIVE: To investigate the profile of motivations for smoking among inpatients at a hospital in southern Brazil. METHODS: A survey study involving hospitalized smokers. The Modified Reasons for Smoking Scale (MRFSS) and its domains were analyzed according to gender and dependence degree. RESULTS: The sample consisted of 85 adults (mean age 53 years), low schooling/family income, and well-adjusted in terms of gender (male= 52.9%) and clinical (48%) or surgical (47%) specialty. Most were in Action as the motivational stage (68%), with elevated smoking exposure (median = 39 years/packs) and dependence degree of nicotine (56.4%). The highest domains of the MRFSS were: Smoking Pleasure (4.34 ± 1.2), Relaxation/Tension Reduction (4.24 ± 1.2) and Dependence (3.8±1.4). Significantly, women presented higher scores, in domain Relaxation/Tension Reduction (4.7±0.9). In those with elevated nicotine dependence, higher scores were observed in the Automatism/Habit and Stimulation domains. CONCLUSIONS: Smoking Pleasure and Relaxation/Tension Reduction, especially in women and Automatism, in those more dependents, are factors that should be more highlighted in future strategies for smoking cessation in inpatients.

RESUMO OBJETIVO: Investigar o perfil de motivações para o tabagismo entre pacientes internados em um hospital do sul do Brasil. MÉTODOS: Estudo tipo survey que incluiu pacientes tabagistas hospitalizados. Utilizou-se a Escala de Razões para Fumar Modificada (ERPFM) e seus domínios, analisados em função do sexo e do grau de dependência. RESULTADOS: A amostra foi composta por 85 adultos (média de 53 anos), com baixa escolaridade/renda familiar e equilibrada quanto ao sexo (masculino= 52,9%) e por especialidade clínica (48%) ou cirúrgica (47%). A maioria estava em estágio motivacional Ação (68%), com carga tabágica (mediana= 39 anos/maços) e grau de dependência à nicotina elevados (56,4%). Os domínios de maior escore da ERPFM foram: Prazer de Fumar (4,34 ± 1,2), Relaxamento/Redução da Tensão (4,24 ± 1,2) e Dependência (3,8 ± 1,4). De forma significativa, com maior pontuação, as mulheres apresentaram o domínio Relaxamento/Redução da Tensão (4,7 ± 0,9). Naqueles com maior grau de dependência, observou-se com significância, escores mais elevados nos domínios Automatismo/Hábito e Estimulação. CONCLUSÕES: Prazer de Fumar e Relaxamento/Redução da Tensão, especialmente em mulheres e Automatismo, naqueles mais dependentes, são fatores que devem ser mais valorizados em futuras estratégias de cessação de tabagismo em hospitalizados.

Adenocarcinoma mucinoso de anexo cutâneo: relato de caso / Mucinous Adenocarcinoma of Skin Annex: a Case Report

Introdução: O adenocarcinoma mucinoso é uma rara neoplasia formada por células apócrinas da pele hipersecretoras de muco. Pálpebras, couro cabeludo e outras regiões da cabeça e do pescoço são os sítios primários mais acometidos. Relatodo caso: Os autores descrevem o caso de uma lesão suspeita em couro cabeludo, cuja excisão e análise confirmaram um adenocarcino mamucinoso de anexo cutâneo. Mesmo após a ressecção, surgiram lesões metastáticas nas regiões retroauricular, cervical, supraclavicular e couro cabeludo. Fez-se, então, quimioterapia e radioterapia. Meses depois, a paciente relatou dor na coluna e no braço com irradiação para a mão e parestesias. Após exames, confirmou-se metástaseem linfonodos axilares, em ossos da coluna vertebral, com iminente compressão medular. A radioterapia, então, foi realizada nessas regiões. A paciente apresentou melhora significativa e mantém acompanhamento. Conclusão: O adenocarcinoma mucinoso é uma rara neoplasia e as características do relato apresentado tornam-no ainda mais raro. O diagnóstico da doença exige uma correlação clínica, radiológica e patológica. Quando submetidos a tratamento precoce, os pacientesapresentam um bom prognóstico com raras chances de metástases, embora recidivas sejam comuns.