Detalles de la búsqueda
1.
Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.
Bioorg Med Chem Lett;
88: 129304, 2023 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37119973
2.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res;
: 1-7, 2023 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37362320
3.
Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors.
Bioorg Med Chem Lett;
30(21): 127474, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32805407
4.
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
J Biol Chem;
290(17): 11061-74, 2015 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25762719
5.
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Bioorg Med Chem Lett;
26(23): 5729-5731, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27816517
6.
Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).
Bioorg Med Chem Lett;
25(19): 4265-9, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26320619
7.
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg Med Chem Lett;
24(9): 2206-11, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24685542
8.
Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhibit TYK2 signaling.
Methods Enzymol;
667: 685-727, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35525559
9.
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J Med Chem;
65(5): 4121-4155, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35171586
10.
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
J Med Chem;
65(5): 4291-4317, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35179904
11.
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of ß-secretase (BACE).
Bioorg Med Chem Lett;
21(22): 6916-24, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21782431
12.
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Bioorg Med Chem Lett;
21(1): 537-41, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21078556
13.
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorg Med Chem Lett;
21(22): 6909-15, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21974952
14.
Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
Acta Crystallogr F Struct Biol Commun;
77(Pt 1): 22-28, 2021 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33439152
15.
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
J Med Chem;
64(15): 11090-11128, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34270254
16.
Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.
Bioorg Med Chem Lett;
20(9): 2933-7, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20356736
17.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg Med Chem Lett;
19(5): 1451-6, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19201606
18.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
ACS Med Chem Lett;
10(3): 383-388, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891145
19.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem;
62(20): 8953-8972, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31314518
20.
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett;
18(6): 1939-44, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18291645