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1.
BMC Womens Health ; 18(1): 64, 2018 05 09.
Artículo en Inglés | MEDLINE | ID: mdl-29743106

RESUMEN

BACKGROUND: Tubal pathology is a causative factor in 20% of subfertile couples. Traditionally, tubal testing during fertility work-up is performed by hysterosalpingography (HSG). Hysterosalpingo-foam sonography (HyFoSy) is a new technique that is thought to have comparable accuracy as HSG, while it is less expensive and more patient friendly. HyFoSy would be an acceptable alternative for HSG, provided it has similar effectiveness in terms of patient outcomes. METHODS/DESIGN: We aim to compare the effectiveness and costs of management guided by HyFoSy or by HSG. Consenting women will undergo tubal testing by both HyFoSy and HSG in a randomized order during fertility work-up. The study group will consist of 1163 subfertile women between 18 and 41 years old who are scheduled for tubal patency testing during their fertility work-up. Women with anovulatory cycles not responding to ovulation induction, endometriosis, severe male subfertility or a known contrast (iodine) allergy will be excluded. We anticipate that 7 % (N = 82) of the participants will have discordant test results for HyFoSy and HSG. These participants will be randomly allocated to either a management strategy based on HyFoSy or a management strategy based on HSG, resulting in either a diagnostic laparoscopy with chromopertubation or a strategy that assumes tubal patency (intrauterine insemination or expectant management). The primary outcome is ongoing pregnancy leading to live birth within 12 months after randomization. Secondary outcomes are patient pain scores, time to pregnancy, clinical pregnancy, miscarriage rate, multiple pregnancy rate, preterm birth rate and number of additional treatments. Costs will be estimated by counting resource use and calculating unit prices. DISCUSSION: This trial will compare the effectiveness and costs of HyFoSy versus HSG in assessing tubal patency in subfertile women. TRIAL REGISTRATION: Dutch Trial Register (NTR 4746, http://www.trialregister.nl ). Date of registration: 19 August 2014.


Asunto(s)
Enfermedades de las Trompas Uterinas/diagnóstico por imagen , Trompas Uterinas/diagnóstico por imagen , Histerosalpingografía , Infertilidad Femenina/diagnóstico por imagen , Infertilidad Femenina/terapia , Estudios Multicéntricos como Asunto , Ensayos Clínicos Controlados Aleatorios como Asunto , Ultrasonografía/métodos , Aborto Espontáneo/etiología , Adolescente , Adulto , Enfermedades de las Trompas Uterinas/complicaciones , Femenino , Humanos , Histerosalpingografía/efectos adversos , Histerosalpingografía/economía , Infertilidad Femenina/etiología , Laparoscopía/efectos adversos , Nacimiento Vivo , Inducción de la Ovulación , Dolor Asociado a Procedimientos Médicos/etiología , Embarazo , Índice de Embarazo , Técnicas Reproductivas Asistidas , Proyectos de Investigación , Ultrasonografía/efectos adversos , Ultrasonografía/economía , Adulto Joven
2.
Am J Obstet Gynecol ; 212(3): 348.e1-7, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25447962

RESUMEN

OBJECTIVE: To evaluate the management of imminent preterm delivery with respect to prescription of antenatal corticosteroids (ACS) and referral to a tertiary center. STUDY DESIGN: A retrospective cohort study existing of 1 perinatal center and 9 referring hospitals. All women who received their first dose of ACS in 1 of the 10 hospitals between 24+0 and 32+0 weeks of gestation and/or delivered before 32 weeks of gestation from 2005 until 2010. Patients were identified using the electronic database of hospital pharmacies. Main outcome measures were time interval from administration to delivery for different indications and number of women who were not referred in time to a tertiary center. RESULTS: In total, 1375 women received ACS. Main indications were suspected preterm labor (44.7%), preterm prelabor rupture of membranes (15.9%), maternal indication (12.8%), fetal indication (9.2%) and vaginal blood loss (8.4%). Overall, 467 (34.0%) women delivered ≤7 days after ACS administration; 8.7% of women with vaginal blood loss and 54.5% of women with maternal indication. Among the 931 women who received ACS in the secondary hospitals, 452 (48.5%) women were referred to a tertiary hospital and 89 (6.5%) women delivered in a secondary hospital with a gestational age of less than 32 weeks. CONCLUSION: One-third of all women receiving ACS delivered within 7 days and half of the women who received ACS in a secondary hospital were referred to a tertiary center. There seems to be room for improvement regarding the timing of ACS administration and subsequently referral to a tertiary center.


Asunto(s)
Betametasona/uso terapéutico , Rotura Prematura de Membranas Fetales/tratamiento farmacológico , Glucocorticoides/uso terapéutico , Enfermedades del Prematuro/prevención & control , Trabajo de Parto Prematuro/tratamiento farmacológico , Pautas de la Práctica en Medicina/estadística & datos numéricos , Atención Prenatal/métodos , Adulto , Esquema de Medicación , Femenino , Estudios de Seguimiento , Edad Gestacional , Humanos , Recién Nacido , Recien Nacido Prematuro , Estimación de Kaplan-Meier , Masculino , Países Bajos , Embarazo , Nacimiento Prematuro , Atención Prenatal/estadística & datos numéricos , Derivación y Consulta/estadística & datos numéricos , Estudios Retrospectivos , Centros de Atención Secundaria , Centros de Atención Terciaria , Factores de Tiempo
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