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1.

Histone lysine demethylases and their functions in cancer.

Sterling, Jayden; Menezes, Sharleen V; Abbassi, Ramzi H; Munoz, Lenka.

Int J Cancer; 148(10): 2375-2388, 2021 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-33128779

2.

DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells.

Chen, Brianna; McCuaig-Walton, Dylan; Tan, Sean; Montgomery, Andrew P; Day, Bryan W; Kassiou, Michael; Munoz, Lenka; Recasens, Ariadna.

Int J Mol Sci; 22(8)2021 Apr 13.

Artículo en Inglés | MEDLINE | ID: mdl-33924599

3.

Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.

Hoque, Monira; Abbassi, Ramzi H; Froio, Danielle; Man, Jennifer; Johns, Terrance G; Stringer, Brett W; Day, Bryan W; Pajic, Marina; Kassiou, Michael; Munoz, Lenka.

Pharmacol Res; 134: 166-178, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29944980

4.

Synthesis and in vitro evaluation of diverse heterocyclic diphenolic compounds as inhibitors of DYRK1A.

Zhou, Qingqing; Reekie, Tristan A; Abbassi, Ramzi H; Indurthi Venkata, Dinesh; Font, Josep S; Ryan, Renae M; Munoz, Lenka; Kassiou, Michael.

Bioorg Med Chem; 26(22): 5852-5869, 2018 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-30401502

5.

Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: role and targeting.

Gurgis, Fadi Maged Shokry; Ziaziaris, William; Munoz, Lenka.

Mol Pharmacol; 85(2): 345-56, 2014 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-24296859

6.

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.

Eibl, Christoph; Munoz, Lenka; Tomassoli, Isabelle; Stokes, Clare; Papke, Roger L; Gündisch, Daniela.

Bioorg Med Chem; 21(23): 7309-29, 2013 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-24145137

7.

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.

Eibl, Christoph; Tomassoli, Isabelle; Munoz, Lenka; Stokes, Clare; Papke, Roger L; Gündisch, Daniela.

Bioorg Med Chem; 21(23): 7283-308, 2013 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-24156938

8.

Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research.

Sterling, Jayden; Baker, Jennifer R; McCluskey, Adam; Munoz, Lenka.

Nat Commun; 14(1): 3228, 2023 06 03.

Artículo en Inglés | MEDLINE | ID: mdl-37270653

9.

p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells.

Yeung, Yiu To; Bryce, Nicole S; Adams, Seray; Braidy, Nady; Konayagi, Mari; McDonald, Kerrie L; Teo, Charles; Guillemin, Gilles J; Grewal, Thomas; Munoz, Lenka.

J Neurooncol; 109(1): 35-44, 2012 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-22528800

10.

MerTK activity is not necessary for the proliferation of glioblastoma stem cells.

Hoque, Monira; Wai Wong, Siu; Recasens, Ariadna; Abbassi, Ramzi; Nguyen, Nghi; Zhang, Dehui; Stashko, Michael A; Wang, Xiaodong; Frye, Stephen; Day, Bryan W; Baell, Jonathan; Munoz, Lenka.

Biochem Pharmacol; 186: 114437, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33571503

11.

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells.

Recasens, Ariadna; Humphrey, Sean J; Ellis, Michael; Hoque, Monira; Abbassi, Ramzi H; Chen, Brianna; Longworth, Mitchell; Needham, Elise J; James, David E; Johns, Terrance G; Day, Bryan W; Kassiou, Michael; Yang, Pengyi; Munoz, Lenka.

Cell Death Discov; 7(1): 81, 2021 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-33863878

12.

Fluorescence polarization binding assay to develop inhibitors of inactive p38alpha mitogen-activated protein kinase.

Munoz, Lenka; Selig, Roland; Yeung, Yiu To; Peifer, Christian; Hauser, Dominik; Laufer, Stefan.

Anal Biochem; 401(1): 125-33, 2010 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-20175985

13.

MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells.

Phoa, Athena F; Recasens, Ariadna; Gurgis, Fadi M S; Betts, Tara A; Menezes, Sharleen V; Chau, Diep; Nordfors, Kristiina; Haapasalo, Joonas; Haapasalo, Hannu; Johns, Terrance G; Stringer, Brett W; Day, Bryan W; Buckland, Michael E; Lalaoui, Najoua; Munoz, Lenka.

Cancers (Basel); 12(3)2020 Mar 11.

Artículo en Inglés | MEDLINE | ID: mdl-32168910

14.

Targeting Cancer Cell Dormancy.

Recasens, Ariadna; Munoz, Lenka.

Trends Pharmacol Sci; 40(2): 128-141, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30612715

15.

Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents.

Abbassi, Ramzi H; Recasens, Ariadna; Indurthi, Dinesh C; Johns, Terrance G; Stringer, Brett W; Day, Bryan W; Munoz, Lenka.

ACS Pharmacol Transl Sci; 2(6): 402-413, 2019 Dec 13.

Artículo en Inglés | MEDLINE | ID: mdl-32259073

16.

Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y.

Escobar, Stephane J de M; Fong, Genevieve M; Winnischofer, Sheila M B; Simone, Martin; Munoz, Lenka; Dennis, Joanne M; Rocha, Maria Eliane M; Witting, Paul K.

Chem Biol Interact; 299: 77-87, 2019 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-30502331

17.

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

Munoz, Lenka; Ralay Ranaivo, Hantamalala; Roy, Saktimayee M; Hu, Wenhui; Craft, Jeffrey M; McNamara, Laurie K; Chico, Laura Wing; Van Eldik, Linda J; Watterson, D Martin.

J Neuroinflammation; 4: 21, 2007 Sep 04.

Artículo en Inglés | MEDLINE | ID: mdl-17784957

18.

Non-kinase targets of protein kinase inhibitors.

Munoz, Lenka.

Nat Rev Drug Discov; 16(6): 424-440, 2017 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-28280261

19.

Kinase targets in CNS drug discovery.

Gunosewoyo, Hendra; Yu, Lifang; Munoz, Lenka; Kassiou, Michael.

Future Med Chem; 9(3): 303-314, 2017 03.

Artículo en Inglés | MEDLINE | ID: mdl-28176536

20.

Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent.

Döbber, Alexander; Phoa, Athena F; Abbassi, Ramzi H; Stringer, Brett W; Day, Bryan W; Johns, Terrance G; Abadleh, Mohammed; Peifer, Christian; Munoz, Lenka.

ACS Med Chem Lett; 8(4): 395-400, 2017 Apr 13.

Artículo en Inglés | MEDLINE | ID: mdl-28435525

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