Detalles de la búsqueda
1.
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
19(2): 451-8, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19054673
2.
5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
19(21): 6047-52, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19796938
3.
Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
19(22): 6404-12, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19818610
4.
Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.
Bioorg Med Chem Lett;
18(11): 3369-75, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18440814
5.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
Bioorg Med Chem Lett;
18(4): 1419-24, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18226901
6.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Bioorg Med Chem Lett;
18(4): 1413-8, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18242088
7.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
Bioorg Med Chem Lett;
18(20): 5635-9, 2008 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18796353
8.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Bioorg Med Chem Lett;
18(11): 3421-6, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18442904
9.
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
18(12): 3616-21, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18487044
10.
Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett;
18(14): 4181-5, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18554907
11.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Bioorg Med Chem Lett;
18(11): 3446-55, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18457949
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