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1.
Microsc Microanal ; 19 Suppl 5: 99-104, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23920184

RESUMEN

In this paper, we have observed an atomic-scale structure and compositional variation at the interface of the InGaN/GaN multi-quantum wells (MQW) by both scanning transmission electron microscopy (STEM) using high-angle annular dark-field mode and atom probe tomography (APT). The iso-concentration analysis of APT results revealed that the roughness of InGaN/GaN interface increased as the MQW layers were filled up, and that the upper interface of MQW (GaN/InGaN to the p-GaN side) was much rougher than that of the lower interface (InGaN/GaN tot he n-GaN side). On the basis of experimental results, it is suggested that the formation of interface roughness can affect the quantum efficiency of InGaN-based light-emitting diodes.

2.
Mol Cell Biol ; 24(1): 172-85, 2004 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-14673153

RESUMEN

In Drosophila melanogaster, although the NF-kappaB transcription factors play a pivotal role in the inducible expression of innate immune genes, such as antimicrobial peptide genes, the exact regulatory mechanism of the tissue-specific constitutive expression of these genes in barrier epithelia is largely unknown. Here, we show that the Drosophila homeobox gene product Caudal functions as the innate immune transcription modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner. These results suggest that certain epithelial tissues have evolved a unique constitutive innate immune strategy by recruiting a developmental "master control" gene.


Asunto(s)
Péptidos Catiónicos Antimicrobianos/genética , Drosophila melanogaster/genética , Epitelio/metabolismo , Proteínas de Homeodominio/genética , Animales , Péptidos Catiónicos Antimicrobianos/biosíntesis , Proteínas de Drosophila , Drosophila melanogaster/metabolismo , Proteínas de Homeodominio/metabolismo , Inmunidad Innata/fisiología , Regiones Promotoras Genéticas , Factores de Transcripción
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