Detalles de la búsqueda
1.
VISTA is an acidic pH-selective ligand for PSGL-1.
Nature;
574(7779): 565-570, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31645726
2.
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.
Bioorg Med Chem Lett;
30(7): 126955, 2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32035698
3.
Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett;
24(21): 5045-9, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25266782
4.
Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).
Bioorg Med Chem Lett;
24(2): 654-60, 2014 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24360604
5.
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).
Bioorg Med Chem Lett;
21(22): 6699-704, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21983439
6.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett;
21(22): 6693-8, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21983444
7.
Closing the side-chain gap in protein loop modeling.
J Comput Aided Mol Des;
23(7): 411-8, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19459054
8.
Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1.
AAPS J;
21(5): 94, 2019 07 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31342199
9.
Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.
Biochim Biophys Acta;
1774(9): 1184-91, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17707701
10.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett;
18(11): 3168-72, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18485702
11.
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett;
9(12): 1170-1174, 2018 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30613321
12.
Loopholes and missing links in protein modeling.
Protein Sci;
16(9): 1999-2012, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17660258
13.
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J Med Chem;
60(12): 4932-4948, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28537398
14.
A comparative study of available software for high-accuracy homology modeling: from sequence alignments to structural models.
Protein Sci;
15(4): 808-24, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16600967
15.
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett;
5(7): 803-8, 2014 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25050169
16.
Engineering enzymes for improved catalytic efficiency: a computational study of site mutagenesis in epothilone-B hydroxylase.
Protein Eng Des Sel;
22(4): 257-66, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19179341
17.
A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series.
Bioorg Med Chem Lett;
15(17): 3816-20, 2005 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15993593
18.
An assessment of protein-ligand binding site polarizability.
Biopolymers;
70(2): 201-11, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14517908
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