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1.

Beta cell-specific CD8⁺ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.

Abdelsamed, Hossam A; Zebley, Caitlin C; Nguyen, Hai; Rutishauser, Rachel L; Fan, Yiping; Ghoneim, Hazem E; Crawford, Jeremy Chase; Alfei, Francesca; Alli, Shanta; Ribeiro, Susan Pereira; Castellaw, Ashley H; McGargill, Maureen A; Jin, Hongjian; Boi, Shannon K; Speake, Cate; Serti, Elisavet; Turka, Laurence A; Busch, Michael E; Stone, Mars; Deeks, Steven G; Sekaly, Rafick-Pierre; Zehn, Dietmar; James, Eddie A; Nepom, Gerald T; Youngblood, Ben.

Nat Immunol; 21(5): 578-587, 2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32231298

2.

A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.

Mathieu, Chantal; Wiedeman, Alice; Cerosaletti, Karen; Long, S Alice; Serti, Elisavet; Cooney, Laura; Vermeiren, Joan; Caluwaerts, Silvia; Van Huynegem, Karolien; Steidler, Lothar; Blomme, Sven; Rottiers, Pieter; Nepom, Gerald T; Herold, Kevan C.

Diabetologia; 67(1): 27-41, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37782353

3.

Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial.

Huffaker, Michelle F; Kanchan, Kanika; Bahnson, Henry T; Baloh, Carolyn; Lack, Gideon; Nepom, Gerald T; Mathias, Rasika A.

J Allergy Clin Immunol; 151(4): 841-847, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36732171

4.

Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy.

Huffaker, Michelle F; Kanchan, Kanika; Bahnson, Henry T; Ruczinski, Ingo; Shankar, Gautam; Leung, Donald Y M; Baloh, Carolyn; Du Toit, George; Lack, Gideon; Nepom, Gerald T; Mathias, Rasika A.

J Allergy Clin Immunol; 151(4): 1137-1142.e4, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36403663

5.

Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A randomized controlled trial.

Corren, Jonathan; Larson, David; Altman, Matthew C; Segnitz, R Max; Avila, Pedro C; Greenberger, Paul A; Baroody, Fuad; Moss, Mark H; Nelson, Harold; Burbank, Allison J; Hernandez, Michelle L; Peden, David; Saini, Sarbjit; Tilles, Stephen; Hussain, Iftikhar; Whitehouse, Don; Qin, Tielin; Villarreal, Miguel; Sever, Michelle; Wheatley, Lisa M; Nepom, Gerald T; Sanda, Srinath.

J Allergy Clin Immunol; 151(1): 192-201, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36223848

6.

Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy.

Calise, Justine; DeBerg, Hannah; Garabatos, Nahir; Khosa, Sugandhika; Bajzik, Veronique; Calderon, Lorena Botero; Aldridge, Kelly; Rosasco, Mario; Ferslew, Brian C; Zhu, Tong; Smulders, Ronald; Wheatley, Lisa M; Laidlaw, Tanya M; Qin, Tielin; Chichili, Gurunadh R; Adelman, Daniel C; Farrington, Mary; Robinson, David; Jeong, David; Jones, Stacie M; Sanda, Srinath; Larson, David; Kwok, William W; Baloh, Carolyn; Nepom, Gerald T; Wambre, Erik.

J Allergy Clin Immunol; 152(1): 155-166.e9, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-37003475

7.

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

Obermoser, Gerlinde; Presnell, Scott; Domico, Kelly; Xu, Hui; Wang, Yuanyuan; Anguiano, Esperanza; Thompson-Snipes, Luann; Ranganathan, Rajaram; Zeitner, Brad; Bjork, Anna; Anderson, David; Speake, Cate; Ruchaud, Emily; Skinner, Jason; Alsina, Laia; Sharma, Mamta; Dutartre, Helene; Cepika, Alma; Israelsson, Elisabeth; Nguyen, Phuong; Nguyen, Quynh-Anh; Harrod, A Carson; Zurawski, Sandra M; Pascual, Virginia; Ueno, Hideki; Nepom, Gerald T; Quinn, Charlie; Blankenship, Derek; Palucka, Karolina; Banchereau, Jacques; Chaussabel, Damien.

Immunity; 38(4): 831-44, 2013 Apr 18.

Artículo en Inglés | MEDLINE | ID: mdl-23601689

8.

Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy.

Shamji, Mohamed H; Larson, David; Eifan, Aarif; Scadding, Guy W; Qin, Tielin; Lawson, Kaitie; Sever, Michelle L; Macfarlane, Ellen; Layhadi, Janice A; Würtzen, Peter A; Parkin, Rebecca V; Sanda, Srinath; Harris, Kristina M; Nepom, Gerald T; Togias, Alkis; Durham, Stephen R.

J Allergy Clin Immunol; 148(4): 1061-1071.e11, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-33819508

9.

Animal models of human type 1 diabetes.

von Herrath, Matthias; Nepom, Gerald T.

Nat Immunol; 10(2): 129-32, 2009 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-19148193

10.

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance.

Glatigny, Simon; Höllbacher, Barbara; Motley, Samantha J; Tan, Cathy; Hundhausen, Christian; Buckner, Jane H; Smilek, Dawn; Khoury, Samia J; Ding, Linna; Qin, Tielin; Pardo, Jorge; Nepom, Gerald T; Turka, Laurence A; Harris, Kristina M; Campbell, Daniel J; Bettelli, Estelle.

J Immunol; 202(5): 1373-1382, 2019 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-30683697

11.

Prediction and pathogenesis in type 1 diabetes.

Ziegler, Anette-G; Nepom, Gerald T.

Immunity; 32(4): 468-78, 2010 Apr 23.

Artículo en Inglés | MEDLINE | ID: mdl-20412757

12.

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to ß Cell Antigens Are Focused on a Unique Set of Epitopes.

Yang, Junbao; Wen, Xiaomin; Xu, Hengyu; Torres-Chinn, Nadia; Speake, Cate; Greenbaum, Carla J; Nepom, Gerald T; Kwok, William W.

J Immunol; 199(1): 91-96, 2017 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-28550202

13.

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4⁺ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Cerosaletti, Karen; Barahmand-Pour-Whitman, Fariba; Yang, Junbao; DeBerg, Hannah A; Dufort, Matthew J; Murray, Sara A; Israelsson, Elisabeth; Speake, Cate; Gersuk, Vivian H; Eddy, James A; Reijonen, Helena; Greenbaum, Carla J; Kwok, William W; Wambre, Erik; Prlic, Martin; Gottardo, Raphael; Nepom, Gerald T; Linsley, Peter S.

J Immunol; 199(1): 323-335, 2017 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-28566371

14.

Omics-oriented research illustrated with the LEAP study and the OASIS bioinformatics tool.

Baloh, Carolyn H; Kanchan, Kanika; Shankar, Gautam; Nepom, Gerald T; Mathias, Rasika A; Perry, James A.

J Allergy Clin Immunol; 151(2): 416-419, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-36521801

15.

Synchronous immune alterations mirror clinical response during allergen immunotherapy.

Renand, Amedee; Shamji, Mohamed H; Harris, Kristina M; Qin, Tielin; Wambre, Erik; Scadding, Guy W; Wurtzen, Peter A; Till, Stephen J; Togias, Alkis; Nepom, Gerald T; Kwok, William W; Durham, Stephen R.

J Allergy Clin Immunol; 141(5): 1750-1760.e1, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29128670

16.

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Bonifacio, Ezio; Mathieu, Chantal; Nepom, Gerald T; Ziegler, Anette-G; Anhalt, Henry; Haller, Michael J; Harrison, Leonard C; Hebrok, Matthias; Kushner, Jake A; Norris, Jill M; Peakman, Mark; Powers, Alvin C; Todd, John A; Atkinson, Mark A.

Diabetologia; 60(1): 35-38, 2017 01.

Artículo en Inglés | MEDLINE | ID: mdl-27785529

17.

Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.

Long, S Alice; Thorpe, Jerill; Herold, Kevan C; Ehlers, Mario; Sanda, Srinath; Lim, Noha; Linsley, Peter S; Nepom, Gerald T; Harris, Kristina M.

Cell Immunol; 319: 3-9, 2017 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-28844471

18.

Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.

Ali, Riyasat; Babad, Jeffrey; Follenzi, Antonia; Gebe, John A; Brehm, Michael A; Nepom, Gerald T; Shultz, Leonard D; Greiner, Dale L; DiLorenzo, Teresa P.

Immunology; 148(4): 339-51, 2016 08.

Artículo en Inglés | MEDLINE | ID: mdl-27124592

19.

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

Buckner, Jane H; Nepom, Gerald T.

J Autoimmun; 71: 44-50, 2016 07.

Artículo en Inglés | MEDLINE | ID: mdl-26948997

20.

Biomarkers for antigen immunotherapy in allergy and type 1 diabetes.

Odegard, Jared M; Nepom, Gerald T; Wambre, Erik.

Clin Immunol; 161(1): 44-50, 2015 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-26122171

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