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1.
Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma.
Int J Cancer;
144(12): 3146-3159, 2019 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30536898
2.
Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM.
Haematologica;
104(9): 1804-1811, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655370
3.
Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition.
Bioconjug Chem;
29(6): 2100-2106, 2018 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29851469
4.
PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS.
NMR Biomed;
30(9)2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28543772
5.
Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma.
Br J Cancer;
115(7): 797-804, 2016 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27560551
6.
Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.
Br J Cancer;
115(6): 682-90, 2016 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27529512
7.
Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases.
Org Biomol Chem;
13(18): 5279-84, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25858034
8.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
J Med Chem;
65(9): 6513-6540, 2022 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35468293
9.
MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.
Bioorg Med Chem Lett;
21(19): 5916-9, 2011 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21875801
10.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
J Med Chem;
64(7): 4071-4088, 2021 04 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33761253
11.
Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.
Org Biomol Chem;
8(10): 2397-407, 2010 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20448898
12.
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
RSC Med Chem;
11(6): 707-731, 2020 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33479670
13.
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
J Clin Invest;
130(1): 258-271, 2020 01 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31581151
14.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.
Eur J Med Chem;
178: 530-543, 2019 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31212132
15.
Pharmacokinetic investigation of imatinib using accelerator mass spectrometry in patients with chronic myeloid leukemia.
Clin Cancer Res;
13(14): 4164-9, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17634544
16.
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
Cancer Res;
66(10): 5354-62, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16707462
17.
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Mol Cancer Ther;
6(3): 945-56, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17363489
18.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
J Med Chem;
50(8): 1958-72, 2007 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17371003
19.
An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.
Cancer Chemother Pharmacol;
59(2): 197-206, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16721548
20.
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
Oncotarget;
8(69): 113418-113430, 2017 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29371919