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1.
Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282.
Biochem Biophys Res Commun;
637: 267-275, 2022 12 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36410276
2.
Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization.
Bioorg Med Chem;
28(24): 115819, 2020 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33120078
3.
Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms.
Xenobiotica;
49(5): 528-539, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29771166
4.
LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization.
Eur J Pharmacol;
891: 173685, 2021 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33127363
5.
Discovery of Potent, Selective, and State-Dependent NaV1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure-Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides.
J Med Chem;
63(11): 6107-6133, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32368909
6.
Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.
J Med Chem;
63(3): 944-960, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31755711
7.
Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models.
Eur J Drug Metab Pharmacokinet;
43(3): 331-346, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29250739
8.
Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice.
Eur J Drug Metab Pharmacokinet;
42(5): 835-847, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28194579
9.
Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats.
Int J Cardiol;
126(1): 123-6, 2008 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-17467089
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