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Bioorg Med Chem Lett
; 16(8): 2076-80, 2006 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16464588
RESUMEN
The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure-activity relationship (SAR) studies of this class of compounds led to the identification of compound 1 which demonstrated a canine whole blood COX-2 inhibitory IC50 of 12 nM and selectivity ratio of COX-1/COX-2 greater than 4000-fold.