Detalles de la búsqueda
1.
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg Med Chem Lett;
27(6): 1478-1483, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28190634
2.
Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis.
J Pharmacol Exp Ther;
359(1): 207-14, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27516465
3.
Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.
J Pharmacol Exp Ther;
356(3): 635-44, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26740668
4.
Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Bioorg Med Chem Lett;
26(14): 3274-3277, 2016 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27261179
5.
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Bioorg Med Chem Lett;
26(19): 4824-4828, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27554445
6.
Exploring the known chemical space of the plant kingdom: insights into taxonomic patterns, knowledge gaps, and bioactive regions.
J Cheminform;
15(1): 107, 2023 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37950325
7.
Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Biochim Biophys Acta Gen Subj;
1865(2): 129800, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33246032
8.
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies.
J Med Chem;
63(20): 11397-11419, 2020 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32511920
9.
Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
J Med Chem;
61(5): 2041-2051, 2018 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29425457
10.
Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain.
J Med Chem;
60(1): 66-88, 2017 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27779399
11.
Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.
J Med Chem;
49(21): 6155-7, 2006 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034120
12.
Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
ACS Med Chem Lett;
7(9): 857-61, 2016 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27660691
13.
Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.
J Med Chem;
59(1): 194-205, 2016 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26653180
14.
Synthesis of cryptophycin 52 using the Shi epoxidation.
Org Lett;
4(10): 1813-5, 2002 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-12000306
15.
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies.
Bioorg Med Chem Lett;
17(20): 5563-6, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17804226
16.
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.
Bioorg Med Chem Lett;
17(13): 3570-4, 2007 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17485205
17.
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.
Bioorg Med Chem Lett;
17(17): 4824-8, 2007 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17614275
18.
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: functionalization of the benzopyran A-ring.
Bioorg Med Chem Lett;
17(18): 5082-5, 2007 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17662603
19.
Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).
Bioorg Med Chem Lett;
15(24): 5526-30, 2005 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16202586
20.
Synthesis of constrained raloxifene analogues by complementary use of Friedel-Crafts and directed remote metalation reactions.
J Org Chem;
68(15): 5992-9, 2003 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-12868938