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1.

Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don't.

Novikoff, Aaron; Müller, Timo D.

Physiology (Bethesda); 39(3): 142-156, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38353610

2.

Pharmacological targeting of α3ß4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.

Jall, Sigrid; De Angelis, Meri; Lundsgaard, Anne-Marie; Fritzen, Andreas M; Nicolaisen, Trine S; Klein, Anders B; Novikoff, Aaron; Sachs, Stephan; Richter, Erik A; Kiens, Bente; Schramm, Karl-Werner; Tschöp, Matthias H; Stemmer, Kerstin; Clemmensen, Christoffer; Müller, Timo D; Kleinert, Maximilian.

Diabetologia; 63(6): 1236-1247, 2020 06.

Artículo en Inglés | MEDLINE | ID: mdl-32140744

3.

Antagonizing GIPR adds fire to the GLP-1R flame.

Novikoff, Aaron; Müller, Timo D.

Trends Endocrinol Metab; 2024 May 18.

Artículo en Inglés | MEDLINE | ID: mdl-38763780

4.

Global, neuronal or ß cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.

Grandl, Gerald; Collden, Gustav; Feng, Jin; Bhattacharya, Sreya; Klingelhuber, Felix; Schomann, Leopold; Bilekova, Sara; Xu, Weiwei; Far, Fataneh Fathi; Tost, Monica; Gruber, Tim; Bastidas-Ponce, Aimée; Zhang, Qian; Novikoff, Aaron; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Garcia-Caceres, Cristina; Feuchtinger, Annette; Tschöp, Matthias H; Krahmer, Natalie; Lickert, Heiko; Müller, Timo D.

Nat Metab; 6(3): 448-457, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38418586

5.

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.

Akindehin, Seun; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Bernecker, Miriam; Garcia-Caceres, Cristina; Drucker, Daniel J; Finan, Brian; Grandl, Gerald; Gutgesell, Robert; Hofmann, Susanna M; Khalil, Ahmed; Liu, Xue; Cota, Perla; Bakhti, Mostafa; Czarnecki, Oliver; Bastidas-Ponce, Aimée; Lickert, Heiko; Kang, Lingru; Maity, Gandhari; Novikoff, Aaron; Parlee, Sebastian; Pathak, Ekta; Schriever, Sonja C; Sterr, Michael; Ussar, Siegfried; Zhang, Qian; DiMarchi, Richard; Tschöp, Matthias H; Pfluger, Paul T; Douros, Jonathan D; Müller, Timo D.

Mol Metab; 83: 101915, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38492844

6.

The molecular pharmacology of glucagon agonists in diabetes and obesity.

Novikoff, Aaron; Müller, Timo D.

Peptides; 165: 171003, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-36997003

7.

SURMOUNTing body weight barriers in type 2 diabetes.

Novikoff, Aaron; Müller, Timo D.

Med; 4(12): 849-851, 2023 Dec 08.

Artículo en Inglés | MEDLINE | ID: mdl-38070476

8.

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.

Khajavi, Noushafarin; Beck, Andreas; Riçku, Klea; Beyerle, Philipp; Jacob, Katharina; Syamsul, Sabrina F; Belkacemi, Anouar; Reinach, Peter S; Schreier, Pascale Cf; Salah, Houssein; Popp, Tanja; Novikoff, Aaron; Breit, Andreas; Chubanov, Vladimir; Müller, Timo D; Zierler, Susanna; Gudermann, Thomas.

JCI Insight; 8(3)2023 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-36574297

9.

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.

El, Kimberley; Douros, Jonathan D; Willard, Francis S; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschöp, Mattias H; Finan, Brian; D'Alessio, David A; Sloop, Kyle W; Müller, Timo D; Campbell, Jonathan E.

Nat Metab; 5(6): 945-954, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-37277609

10.

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.

Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Ständer, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L; He, Yantao; Knerr, Patrick J; Yang, Bin; Hogendorf, Wouter F J; Zhang, Shiqi; Hofmann, Susanna M; Finan, Brian; DiMarchi, Richard D; Tschöp, Matthias H; Douros, Jonathan D; Müller, Timo D.

Nat Metab; 5(12): 2075-2085, 2023 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-37946085

11.

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.

Sekar, Revathi; Motzler, Karsten; Kwon, Yun; Novikoff, Aaron; Jülg, Julia; Najafi, Bahar; Wang, Surui; Warnke, Anna-Luisa; Seitz, Susanne; Hass, Daniela; Gancheva, Sofiya; Kahl, Sabine; Yang, Bin; Finan, Brian; Schwarz, Kathrin; Okun, Juergen G; Roden, Michael; Blüher, Matthias; Müller, Timo D; Krahmer, Natalie; Behrends, Christian; Plettenburg, Oliver; Miaczynska, Marta; Herzig, Stephan; Zeigerer, Anja.

Cell Metab; 34(11): 1824-1842.e9, 2022 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-36243006

12.

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.

Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Baugé, Eric; Campbell, Jonathan E; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M; Knerr, Patrick J; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D; Tschöp, Matthias H; Finan, Brian; Müller, Timo D.

Nat Metab; 4(8): 1071-1083, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35995995

13.

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.

Novikoff, Aaron; O'Brien, Shannon L; Bernecker, Miriam; Grandl, Gerald; Kleinert, Maximilian; Knerr, Patrick J; Stemmer, Kerstin; Klingenspor, Martin; Zeigerer, Anja; DiMarchi, Richard; Tschöp, Matthias H; Finan, Brian; Calebiro, Davide; Müller, Timo D.

Mol Metab; 49: 101181, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33556643

14.

Gut Peptide Agonism in the Treatment of Obesity and Diabetes.

Grandl, Gerald; Novikoff, Aaron; DiMarchi, Richard; Tschöp, Matthias H; Müller, Timo D.

Compr Physiol; 10(1): 99-124, 2019 12 18.

Artículo en Inglés | MEDLINE | ID: mdl-31853954

15.

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.

Sekar, Revathi; Motzler, Karsten; Kwon, Yun; Novikoff, Aaron; Jülg, Julia; Najafi, Bahar; Wang, Surui; Warnke, Anna-Luisa; Seitz, Susanne; Hass, Daniela; Gancheva, Sofiya; Kahl, Sabine; Yang, Bin; Finan, Brian; Schwarz, Kathrin; Okun, Juergen G; Roden, Michael; Blüher, Matthias; Müller, Timo D; Krahmer, Natalie; Behrends, Christian; Plettenburg, Oliver; Miaczynska, Marta; Herzig, Stephan; Zeigerer, Anja.

Cell Metab; 34(12): 2047, 2022 Dec 06.

Artículo en Inglés | MEDLINE | ID: mdl-36476936

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Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don't.

Pharmacological targeting of α3ß4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.

Antagonizing GIPR adds fire to the GLP-1R flame.

Global, neuronal or ß cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.

The molecular pharmacology of glucagon agonists in diabetes and obesity.

SURMOUNTing body weight barriers in type 2 diabetes.

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.

Gut Peptide Agonism in the Treatment of Obesity and Diabetes.

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.