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Biosci Biotechnol Biochem ; 88(6): 679-688, 2024 May 22.
Artículo en Inglés | MEDLINE | ID: mdl-38499443

RESUMEN

Recently, it has been suggested that brown and beige adipocytes may ameliorate obesity because these adipocytes express uncoupling protein-1 (UCP-1), which generates heat by consuming lipid. However, obesity-induced inflammation suppresses the expression of UCP-1. To improve such conditions, food components with anti-inflammatory properties are attracting attention. In this study, we developed a modified system to evaluate only the indirect effects of anti-inflammatory food-derived compounds by optimizing the conventional experimental system using conditioned medium. We validated this new system using 6-shogaol and 6-gingerol, which have been reported to show the anti-inflammatory effects and to increase the basal expression of UCP-1 mRNA. In addition, we found that the acetone extract of Sarcodon aspratus, an edible mushroom, showed anti-inflammatory effects and rescued the inflammation-induced suppression of UCP-1 mRNA expression. These findings indicate that the system with conditioned medium is valuable for evaluation of food-derived compounds with anti-inflammatory effects on the inflammation-induced thermogenic adipocyte dysfunction.


Asunto(s)
Adipocitos , Antiinflamatorios , Inflamación , Macrófagos , ARN Mensajero , Proteína Desacopladora 1 , Proteína Desacopladora 1/metabolismo , Proteína Desacopladora 1/genética , Animales , ARN Mensajero/genética , ARN Mensajero/metabolismo , Ratones , Medios de Cultivo Condicionados/farmacología , Antiinflamatorios/farmacología , Inflamación/tratamiento farmacológico , Inflamación/metabolismo , Inflamación/genética , Adipocitos/efectos de los fármacos , Adipocitos/metabolismo , Macrófagos/efectos de los fármacos , Macrófagos/metabolismo , Línea Celular , Regulación de la Expresión Génica/efectos de los fármacos
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