Detalles de la búsqueda
1.
Design and optimization of selective azaindole amide M1 positive allosteric modulators.
Bioorg Med Chem Lett;
26(2): 650-655, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26631313
2.
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
ACS Med Chem Lett;
14(10): 1427-1433, 2023 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37849537
3.
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity.
J Med Chem;
62(18): 8532-8543, 2019 09 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31483137
4.
Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry.
J Am Soc Mass Spectrom;
29(7): 1524-1531, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29736601
5.
Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors.
Protein Eng Des Sel;
31(5): 159-171, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30247737
6.
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
J Med Chem;
61(7): 3008-3026, 2018 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29498843
7.
Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity.
J Med Chem;
60(15): 6649-6663, 2017 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28598634
8.
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
J Med Chem;
60(18): 7764-7780, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28817277
9.
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
J Med Chem;
59(13): 6313-28, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27275946
10.
Synthesis of (+/-)-Gymnomitrol. Mn(OAc)(3)-Initiated Free-Radical Cyclization of Alkynyl Ketones.
J Org Chem;
62(7): 1970-1975, 1997 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11671498
11.
Advances in the development of novel aggrecanase inhibitors.
Expert Opin Ther Pat;
21(1): 1-12, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21110709
12.
Adnectin CT-322 inhibits tumor growth and affects microvascular architecture and function in Colo205 tumor xenografts.
Int J Oncol;
38(1): 71-80, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21109927
13.
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.
Bioorg Med Chem;
15(3): 1311-22, 2007 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17127070
14.
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.
Bioorg Med Chem Lett;
16(18): 4796-9, 2006 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16870436
15.
Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.
Bioorg Med Chem Lett;
16(18): 4728-32, 2006 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16870441
16.
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Bioorg Med Chem Lett;
16(21): 5659-63, 2006 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16919947
17.
Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.
Bioorg Med Chem Lett;
16(16): 4233-6, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16782334
18.
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors.
Bioorg Med Chem;
14(23): 7880-92, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16908171
19.
Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.
Bioorg Med Chem Lett;
15(19): 4322-6, 2005 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16046129
20.
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.
Bioorg Med Chem Lett;
15(24): 5434-8, 2005 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16216507