Detalles de la búsqueda
1.
Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model.
Antimicrob Agents Chemother;
64(6)2020 05 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32253212
2.
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.
Br J Cancer;
119(10): 1233-1243, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30385821
3.
Global metabolite profiling of human colorectal cancer xenografts in mice using HPLC-MS/MS.
J Proteome Res;
12(6): 2980-6, 2013 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23631600
4.
ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib.
Cancer Res;
82(6): 1140-1152, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35078817
5.
Ce(IV) complexes with donor-functionalized alkoxide ligands: improved precursors for chemical vapor deposition of CeO2.
Inorg Chem;
50(22): 11644-52, 2011 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22017450
6.
Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.
J Med Chem;
64(19): 14377-14425, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34569791
7.
Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity.
Mol Cancer Ther;
7(3): 455-63, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18347133
8.
Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress.
Cancer Res;
79(14): 3762-3775, 2019 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31123088
9.
Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.
Bioorg Med Chem Lett;
18(6): 1904-9, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18294849
10.
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.
Clin Cancer Res;
13(12): 3682-8, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17575233
11.
Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
J Med Chem;
61(22): 9889-9907, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30346772
12.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Mol Cancer Ther;
17(8): 1637-1647, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29769307
13.
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.
J Med Chem;
50(9): 2213-24, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17373783
14.
Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles.
Mol Cancer Ther;
16(6): 1031-1040, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28292940
15.
Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
J Med Chem;
49(3): 955-70, 2006 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16451062
16.
The solid-state structures of dimethylzinc and diethylzinc.
Angew Chem Int Ed Engl;
50(49): 11685-7, 2011 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-21919175
17.
The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.
Cancer Res;
76(20): 6084-6094, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27550455
18.
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.
Sci Transl Med;
8(325): 325ra17, 2016 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26865565
19.
Examining changes in [18 F]FDG and [18 F]FLT uptake in U87-MG glioma xenografts as early response biomarkers to treatment with the dual mTOR1/2 inhibitor AZD8055.
Mol Imaging Biol;
16(3): 421-30, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24249640
20.
Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies.
Cancer Chemother Pharmacol;
71(4): 1021-32, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23355042