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1.

Immune regulation and cytotoxic T cell activation of IL-10 agonists - Preclinical and clinical experience.

Oft, Martin.

Semin Immunol; 44: 101325, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31706853

2.

Immunologic and tumor responses of pegilodecakin with 5-FU/LV and oxaliplatin (FOLFOX) in pancreatic ductal adenocarcinoma (PDAC).

Hecht, J Randolph; Papadopoulos, Kyriakos P; Falchook, Gerald S; Patel, Manish R; Infante, Jeffrey R; Aljumaily, Raid; Wong, Deborah J; Autio, Karen A; Wainberg, Zev A; Bauer, Todd M; Javle, Milind; Pant, Shubham; Bendell, Johanna; Hung, Annie; Ratti, Navneet; VanVlasselaer, Peter; Verma, Rakesh; Leveque, Joseph; Rao, Sujata; Oft, Martin; Naing, Aung.

Invest New Drugs; 39(1): 182-192, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-32910338

3.

Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (IVY): a multicentre, multicohort, open-label, phase 1b trial.

Naing, Aung; Wong, Deborah J; Infante, Jeffrey R; Korn, W Michael; Aljumaily, Raid; Papadopoulos, Kyriakos P; Autio, Karen A; Pant, Shubham; Bauer, Todd M; Drakaki, Alexandra; Daver, Naval G; Hung, Annie; Ratti, Navneet; McCauley, Scott; Van Vlasselaer, Peter; Verma, Rakesh; Ferry, David; Oft, Martin; Diab, Adi; Garon, Edward B; Tannir, Nizar M.

Lancet Oncol; 20(11): 1544-1555, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31563517

4.

Pegylated Interleukin-10: Clinical Development of an Immunoregulatory Cytokine for Use in Cancer Therapeutics.

Autio, Karen; Oft, Martin.

Curr Oncol Rep; 21(2): 19, 2019 02 21.

Artículo en Inglés | MEDLINE | ID: mdl-30790069

5.

Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-Î³-mediated CD8(+) T cell cytotoxicity.

Mumm, John B; Oft, Martin.

Bioessays; 35(7): 623-31, 2013 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-23666891

6.

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.

Teng, Michele W L; Andrews, Daniel M; McLaughlin, Nicole; von Scheidt, Bianca; Ngiow, Shin Foong; Möller, Andreas; Hill, Geoffrey R; Iwakura, Yoichiro; Oft, Martin; Smyth, Mark J.

Proc Natl Acad Sci U S A; 107(18): 8328-33, 2010 May 04.

Artículo en Inglés | MEDLINE | ID: mdl-20404142

7.

Subversion and coercion: the art of redirecting tumor immune surveillance.

Mumm, John B; Oft, Martin.

Curr Top Microbiol Immunol; 344: 25-39, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-20490777

8.

IL-23 promotes tumour incidence and growth.

Langowski, John L; Zhang, Xueqing; Wu, Lingling; Mattson, Jeanine D; Chen, Taiying; Smith, Kathy; Basham, Beth; McClanahan, Terrill; Kastelein, Robert A; Oft, Martin.

Nature; 442(7101): 461-5, 2006 Jul 27.

Artículo en Inglés | MEDLINE | ID: mdl-16688182

9.

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

Oft, Martin; Akhurst, Rosemary J; Balmain, Allan.

Nat Cell Biol; 4(7): 487-94, 2002 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12105419

10.

An orthogonal IL-2 and IL-2Rß system drives persistence and activation of CAR T cells and clearance of bulky lymphoma.

Aspuria, Paul-Joseph; Vivona, Sandro; Bauer, Michele; Semana, Marie; Ratti, Navneet; McCauley, Scott; Riener, Romina; de Waal Malefyt, Rene; Rokkam, Deepti; Emmerich, Jan; Kastelein, Rob A; Lupardus, Patrick J; Oft, Martin.

Sci Transl Med; 13(625): eabg7565, 2021 12 22.

Artículo en Inglés | MEDLINE | ID: mdl-34936383

11.

No immunosurveillance in human IL-10R deficiency.

Oft, Martin.

Blood; 122(23): 3702-3, 2013 Nov 28.

Artículo en Inglés | MEDLINE | ID: mdl-24288405

12.

Interleukin 10-Mediated Response and Correlated Anemia in a Patient with Advanced Non-Small Cell Lung Carcinoma.

Choucair, Khalil; Kelso, Jesse D; Duff, Joseph R; Cassidy, Christine S; Albrethsen, Mary T; Ashraf, Mushtaq; Verghese, Cherian; Oft, Martin; Brunicardi, F Charles; Dworkin, Lance; Nemunaitis, John.

Case Rep Oncol; 12(1): 297-303, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31097939

13.

Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.

Lacher, Markus D; Tiirikainen, Maarit I; Saunier, Elise F; Christian, Christine; Anders, Mario; Oft, Martin; Balmain, Allan; Akhurst, Rosemary J; Korn, Wolfgang Michael.

Cancer Res; 66(3): 1648-57, 2006 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-16452224

14.

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8⁺ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients.

Naing, Aung; Infante, Jeffrey R; Papadopoulos, Kyriakos P; Chan, Ivan H; Shen, Cong; Ratti, Navneet P; Rojo, Bianca; Autio, Karen A; Wong, Deborah J; Patel, Manish R; Ott, Patrick A; Falchook, Gerald S; Pant, Shubham; Hung, Annie; Pekarek, Kara L; Wu, Victoria; Adamow, Matthew; McCauley, Scott; Mumm, John B; Wong, Phillip; Van Vlasselaer, Peter; Leveque, Joseph; Tannir, Nizar M; Oft, Martin.

Cancer Cell; 34(5): 775-791.e3, 2018 11 12.

Artículo en Inglés | MEDLINE | ID: mdl-30423297

15.

PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia.

Chan, Ivan H; Van Hoof, Dennis; Abramova, Marina; Bilardello, Melissa; Mar, Elliot; Jorgensen, Brett; McCauley, Scott; Bal, Harminder; Oft, Martin; Van Vlasselaer, Peter; Mumm, John B.

PLoS One; 11(6): e0156229, 2016.

Artículo en Inglés | MEDLINE | ID: mdl-27299860

16.

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors.

Naing, Aung; Papadopoulos, Kyriakos P; Autio, Karen A; Ott, Patrick A; Patel, Manish R; Wong, Deborah J; Falchook, Gerald S; Pant, Shubham; Whiteside, Melinda; Rasco, Drew R; Mumm, John B; Chan, Ivan H; Bendell, Johanna C; Bauer, Todd M; Colen, Rivka R; Hong, David S; Van Vlasselaer, Peter; Tannir, Nizar M; Oft, Martin; Infante, Jeffrey R.

J Clin Oncol; 34(29): 3562-3569, 2016 10 10.

Artículo en Inglés | MEDLINE | ID: mdl-27528724

17.

The Potentiation of IFN-Î³ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells.

Chan, Ivan Ho; Wu, Victoria; Bilardello, Melissa; Mar, Elliot; Oft, Martin; Van Vlasselaer, Peter; Mumm, John Brian.

J Interferon Cytokine Res; 35(12): 948-55, 2015 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-26309093

18.

IL-10: master switch from tumor-promoting inflammation to antitumor immunity.

Oft, Martin.

Cancer Immunol Res; 2(3): 194-9, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24778315

19.

Killing from within.

Mumm, John B; Emmerich, Jan; Oft, Martin.

Oncoimmunology; 1(9): 1598-1600, 2012 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-23264906

20.

Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells.

Emmerich, Jan; Mumm, John B; Oft, Martin.

Oncoimmunology; 1(9): 1637-1639, 2012 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-23264920

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Immune regulation and cytotoxic T cell activation of IL-10 agonists - Preclinical and clinical experience.

Immunologic and tumor responses of pegilodecakin with 5-FU/LV and oxaliplatin (FOLFOX) in pancreatic ductal adenocarcinoma (PDAC).

Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (IVY): a multicentre, multicohort, open-label, phase 1b trial.

Pegylated Interleukin-10: Clinical Development of an Immunoregulatory Cytokine for Use in Cancer Therapeutics.

Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-Î³-mediated CD8(+) T cell cytotoxicity.

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.

Subversion and coercion: the art of redirecting tumor immune surveillance.

IL-23 promotes tumour incidence and growth.

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

An orthogonal IL-2 and IL-2Rß system drives persistence and activation of CAR T cells and clearance of bulky lymphoma.

No immunosurveillance in human IL-10R deficiency.

Interleukin 10-Mediated Response and Correlated Anemia in a Patient with Advanced Non-Small Cell Lung Carcinoma.

Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8⁺ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients.

PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia.

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors.

The Potentiation of IFN-Î³ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells.

IL-10: master switch from tumor-promoting inflammation to antitumor immunity.

Killing from within.

Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells.