RESUMEN
A 28-year-old woman with systemic lupus erythematosus was referred to our hospital due to nephrotic-level proteinuria despite approximately 1 year of treatment with 50 to 60 mg/d of prednisolone and 100 to 150 mg/d of cyclosporine with methylprednisolone pulse therapy. Kidney biopsy showed diffuse global lupus nephritis (World Health Organization class 4-G A/C) with many intraglomerular foam cells containing cholesterol crystals. Surprisingly, proteinuria diminished after only 5 low-density lipoprotein (LDL) cholesterol apheresis sessions. This case demonstrated the potential of LDL apheresis to exhibit a remarkable effect on not only focal segmental glomerulosclerosis, but also other types of nephritis, particularly nephritis with intraglomerular foam cells.
Asunto(s)
Eliminación de Componentes Sanguíneos , Colesterol/análisis , Células Espumosas/química , Lipoproteínas LDL/administración & dosificación , Nefritis Lúpica/terapia , Proteinuria/terapia , Adulto , Cristalización , Femenino , Células Espumosas/patología , Humanos , Glomérulos Renales/química , Glomérulos Renales/patología , Nefritis Lúpica/complicaciones , Nefritis Lúpica/diagnóstico , Proteinuria/complicaciones , Proteinuria/diagnósticoRESUMEN
Bonner sphere spectrometer (BSS) is used in radiation protection measurement because of its wide energy range (thermal to MeV) and easy operation. Mitsubishi Heavy Industries (MHI) has used BSS to obtain neutron spectrum and has used the neutron spectrum to estimate neutron dose or induced activity. Calibration of BSS is important to estimate precise neutron dose or induced activity. MHI BSS was calibrated at National Institute of Advanced Industrial Science and Technology (AIST). The calibration results at AIST are in good agreement with calculation results.