RESUMEN
BACKGROUND: As more children survive acute myeloid leukemia (AML) it is increasingly important to assess possible late effects of the intensive treatment. Hearing loss has only sporadically been reported in survivors of childhood AML. We assessed hearing status in survivors of childhood AML treated with chemotherapy alone according to 3 consecutive NOPHO-AML trials. PROCEDURE: A population-based cohort of children treated according to the NOPHO-AML-84, NOPHO-AML-88, and NOPHO-AML-93 trials included 137 eligible survivors among whom 101 (74%) completed a questionnaire and 99 (72%) had otologic and audiologic examination performed including otoscopy (72%), pure tone audiometry (70%), and tympanometry (60%). Eighty-four of 93 (90%) eligible sibling controls completed a similar questionnaire. RESULTS: At a median of 11 years (range, 4 to 25) after diagnosis, hearing disorders were rare in survivors of childhood AML and in sibling controls, with no significant differences. None had severe or profound hearing loss diagnosed at audiometry. Audiometry detected a subclinical hearing loss ranging from slight to moderate in 19% of the survivors, 5% had low-frequency hearing loss, and 17% had high-frequency hearing loss. CONCLUSIONS: The frequency of hearing disorders was low, and hearing thresholds in survivors of childhood AML were similar to background populations of comparable age.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica , Trastornos de la Audición , Audición/efectos de los fármacos , Leucemia Mieloide Aguda , Adolescente , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Supervivientes de Cáncer , Niño , Preescolar , Femenino , Estudios de Seguimiento , Trastornos de la Audición/inducido químicamente , Trastornos de la Audición/epidemiología , Humanos , Lactante , Recién Nacido , Leucemia Mieloide Aguda/tratamiento farmacológico , Leucemia Mieloide Aguda/epidemiología , Masculino , Estudios Retrospectivos , HermanosRESUMEN
A natureza do zumbido em 46 pacientes foi investigada usando questionários, em duas ocasioes foram feitas comparaçoes de tons exteriores à sensaçao subjetiva de frequência (tonia) do zumbido individual e foi registrada emissoes otoacústicas espontâneas. A reprodutibilidade dos resultados obtidos nas tentativas de harmonizar tons exteriores à tonia do zumbido era baixa, nao havia uma relaçao estreita entre a sensaçao da intensidade (sonía) e o incômodo do zumbido e tampouco se encontrou uma correlaçao entre a presença de zumbido e de emissoes otoacústicas espontâneas. Foi concluído que é preciso encontrar melhores métodos para avaliar a tonía e a sonia do zumbido.