The advanced lung cancer inflammation index predicts outcomes in patients with Crohn's disease after surgical resection.

AIM: Precise biomarkers for predicting prognosis could help to identify high-risk Crohn's disease (CD) patients to facilitate better follow-up during the postoperative course. In this study, the primary aim is the identification of the most reliable nutrition marker that predicts surgical relapse in CD patients. METHOD: We first evaluated the predictive value of various nutrition markers for postoperative surgical relapse in CD patients and identified the advanced lung cancer inflammation index (ALI) as a promising biomarker. Then, we assessed the clinical significance of preoperative ALI in CD patients using two cohorts. RESULTS: Preoperative ALI showed the highest correlation with reoperation rate compared with other nutritional parameters in CD patients receiving surgical resection (sensitivity 53%, specificity 86%, area under the curve 0.71). Lower levels of preoperative ALI were significantly correlated with the presence of perianal disease. A lower level of preoperative ALI was an independent prognostic factor for reoperation rate after an intestinal resection (hazard ratio 3.37, 95% CI 1.38-10.12, P = 0.006), and the prognostic impact of preoperative ALI was successfully validated in an independent cohort using the same cut-off value. CONCLUSION: Preoperative ALI might be useful for postoperative management of CD patients.

Direct observations of energy transfer from resonant electrons to whistler-mode waves in magnetosheath of Earth.

Electromagnetic whistler-mode waves in space plasmas play critical roles in collisionless energy transfer between the electrons and the electromagnetic field. Although resonant interactions have been considered as the likely generation process of the waves, observational identification has been extremely difficult due to the short time scale of resonant electron dynamics. Here we show strong nongyrotropy, which rotate with the wave, of cyclotron resonant electrons as direct evidence for the locally ongoing secular energy transfer from the resonant electrons to the whistler-mode waves using ultra-high temporal resolution data obtained by NASA's Magnetospheric Multiscale (MMS) mission in the magnetosheath. The nongyrotropic electrons carry a resonant current, which is the energy source of the wave as predicted by the nonlinear wave growth theory. This result proves the nonlinear wave growth theory, and furthermore demonstrates that the degree of nongyrotropy, which cannot be predicted even by that nonlinear theory, can be studied by observations.

Predictors of Cerebral Aneurysm Rupture after Coil Embolization: Single-Center Experience with Recanalized Aneurysms.

BACKGROUND AND PURPOSE: Recanalization after coil embolization is widely studied. However, there are limited data on how recanalized aneurysms rupture. Herein, we describe our experience with the rupture of recanalized aneurysms and discuss the type of recanalized aneurysms at greatest rupture risk. MATERIALS AND METHODS: A total of 426 unruptured aneurysms and 169 ruptured aneurysms underwent coil embolization in our institution between January 2009 and December 2017. Recanalization occurred in 38 (8.9%) of 426 unruptured aneurysms (unruptured group) and 37 (21.9%) of 169 ruptured aneurysms (ruptured group). The Modified Raymond-Roy classification on DSA was used to categorize the recanalization type. Follow-up DSA was scheduled until 6 months after treatment, and follow-up MRA was scheduled yearly. If recanalization was suspected on MRA, DSA was performed. RESULTS: In the unruptured group, the median follow-up term was 74.0 months. Retreatment for recanalization was performed in 18 aneurysms. Four of 20 untreated recanalized aneurysms (0.94% of total coiled aneurysms) ruptured. In untreated recanalized aneurysms, class IIIb aneurysms ruptured significantly more frequently than class II and IIIa (P = .025). In the ruptured group, the median follow-up term was 28.0 months. Retreatment for recanalization was performed in 16 aneurysms. Four of 21 untreated recanalized aneurysms (2.37% of total coiled aneurysms) ruptured. Class IIIb aneurysms ruptured significantly more frequently than class II and IIIa (P = .02). CONCLUSIONS: The types of recanalization after coil embolization may be predictors of rupture. Coiled aneurysms with class IIIb recanalization should undergo early retreatment because of an increased rupture risk.

Palladium adsorbing properties of UV-curable chitosan derivatives and surface analysis of chitosan-containing paint.

The results of X-ray photoelectron spectroscopy (XPS) analyses indicated that palladium chloride was adsorbed on a plastic surface coated with a chitosan-containing paint (C-Paint), and was completely reduced to Pd(0) after reduction with dimethylamine-borane. To improve the stability and hardening properties of C-Paint, UV-curable chitosan derivatives, such as N-[3-methoxy-4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]methylated chitosan and N-(3-methoxy-4-methacryloyloxyphenyl)methylated chitosan, were synthesized. The derivatives showed better affinity for organic solvents. After UV irradiation for 20s, an acidic solution of these derivatives was transformed to a gel, and the dried films exhibited good palladium(II) adsorption at pH 1.1.

UDP-glucose pyrophosphorylase from potato tuber: purification and characterization.

UDP-glucose pyrophosphorylase from potato tuber was purified 243-fold to a nearly homogeneous state with a recovery of 30%. The purified enzyme utilized UDP-glucose, but not ADP-glucose, as the substrate, and was not activated by 3-phosphoglyceric acid. Product inhibition studies revealed the sequential binding of UDP-glucose and MgPPi and the sequential release of glucose-1-phosphate and MgUTP, in this order. Analyses of the effects of Mg2+ on the enzyme activity suggest that the MgPPi and MgUTP complexes are the actual substrates for the enzyme reaction, and that free UTP acts as an inhibitor. The enzyme exists probably as the monomer of an approximately 50-kDa polypeptide with a blocked amino terminus. For structural comparison, 29 peptides isolated from a tryptic digest of the S-carboxymethylated enzyme were sequenced. The results show that the potato tuber enzyme is homologous to UDP-glucose pyrophosphorylase from slime mold, but not to ADP-glucose pyrophosphorylase from Escherichia coli, and provide structural evidence that UDP-glucose and ADP-glucose pyrophosphorylase are two different protein entities.

Re-evaluation of the classical acupuncture concept of meridians in Oriental medicine by the new method of detecting meridian-like network connected to internal organs using "Bi-Digital O-Ring Test".

"Bi-Digital O-Ring Test" has been successfully applied clinically as one of the simplest non-invasive, safe early diagnostic methods as well as localizing specific substances and neuro transmitters and tissues by the " 'Bi-Digital O-Ring Test' Molecular Identification and Localization Method". Using the method most of the internal organs it becomes possible to image the outline of most of the internal organs on most of the body surface without exposing the patient to undesirable radiation of X-Ray or strong magnetic field. While imaging outline of the internal organs the author found that from the surface of each organ, lines or networks of lines extending to the other parts of the body. Such a line closely resembled classically well known lines of meridians of major internal organs in Oriental medicine which author named meridian-like network of each internal organ. Each internal organ's meridian-like network usually can be imaged using microscopic slide of tissue or tissue itself. However, entire part of the small intestine meridian in the arm can also be imaged by heart tissue. For example "spleen meridian" has been considered to represent mainly pancreas of the western medical concept and this was also confirmed by the fact that using microscopic slide of pancreas or dessicated tissue of the pancreas well-known spleen meridian-like network can be imaged. The author also confirmed some of the description of the direction of the meridian and direction of the in reference to the direction of the insertion of the acupuncture needle. The width of the line of this meridian-like network was usually within one or two millimeters and one millimeter outside of the line do not have the same characteristics. This meridian-like network seems to be specialized channel which can propagate some type of information in electro-magnetic field to regulate some of the body functions throughout the body which is difficult to explain in current western medical anatomical concept.

Interrelationships between the heart and central nervous system: localization of neuro-transmitters and imaging of their associated nuclei, including the raphe nuclei & the locus coeruleus, as well as the imaging of the heart and its representation areas in slices of the human central nervous system using the "Bi-Digital O-Ring Test" imaging method.

Using microscopic slides of specific tissues from the human body or pure substances including neuro-transmitters such as serotonin, dopamine, norepinephrine, etc., as reference control substances in the Bi-Digital O-Ring Test Molecular Identification Method, the author was able to localize and image normal and abnormal internal organs, and to localize and trace the distribution of neurotransmitters in the different parts of the central nervous system. Using microscopic slides of different parts of the heart, we were able to image the outline of the heart as well as the SA node, AV node, tricuspid valve, mitral valve, aortic valve, pulmonary valve, coronary arteries, and aorta and its branches, including the vertebral arteries, without using any bulky or expensive imaging instruments. Using serotonin as a reference control substance on the different parts of the central nervous system, it was possible to demonstrate the 6 well-known raphe nuclei and the locus coeruleus (which contains serotonin & norepinephrine), as well as the distribution of serotonin in the cerebrum and the cerebellum, all of which closely resembled previously published well-known neuroanatomical structures and distributions of neurotransmitters. As an extension of this work, possible representations of different internal organs on the central nervous system were examined using microscopic slides of different internal organs as reference control substances. The results indicated that the entire heart is represented primarily in the medulla oblongata, and that the SA node and the upper half of the left atrium are represented in the caudal end of the pons; the right side of the heart (i.e. R-atrium, AV node, tricuspid valve, R-ventricle) is represented on the right side of the medulla oblongata, and the left side of the heart (i.e. lower half of the L-atrium, mitral valve, L-ventricle) is represented on the left side of the medulla oblongata, and the upper half of the left atrium is represented in the caudal end of the left side of the pons. The bottoms of the ventricles are located near the spinal cord. Furthermore, the right and the left sides of the heart are represented in specific areas of each side of the right and left hemispheres of the cerebral cortex, and there are connecting pathways between the representation areas of identical parts of the heart, through the corpus callosum and other neuro-pathways.

Basic electrical parameters for safe and effective electro-therapeutics [electro-acupuncture, TES, TENMS (or TEMS), TENS and electro-magnetic field stimulation with or without drug field] for pain, neuromuscular skeletal problems, and circulatory disturbances.

Using voltage-time-dependent negative resistance characteristics of Voltage-Current curves of excitable cell membranes estimated without using artificial voltage clamp method, the author made a quantitative analysis of excitability of cell membranes and different conditions of transmembrane action potentials as a bias voltage to the negative resistance of the excitable cell membrane. The pacemaker cells were classified as "Astable Oscillators" and nonpacemaker excitable cells as "Monostable Oscillators," and application of a rapidly changing electromagnetic field to the cells was analyzed as a means of stimulating the cells. The understanding of the 10 essential electrical parameters is highly desirable for safe and effective electrical stimulation. Among these, emphasis was placed on the often neglected, important electrical parameters of "output impedance" of stimulation pulse wave complexes for + and - polarity components, as well as the importance of capacitive current (Ic = C.dV/dt) which depends on rise time as well as fall time of the stimulation pulse wave, and undesirable side effects of electrolysis phenomena due to excessive D.C. current. The difference and similarity between TENS (Transcutaneous Nerve Stimulation) and TES (Transcutaneous Electrical Stimulation), TENMS (Transcutaneous Electrical Nerve and Muscle Stimulation) or TMS (Transcutaneous Muscle Stimulation) was discussed. The author's clinical study indicated that effective TES (TENMS)--characterized by effective muscle contraction without creating pain with a pulse repetition rate approximately the same as the heart rate of the individual--can often give superior beneficial effects in improvement of micro-circulation and subsequent relief of pain and other symptoms compared with TENS that creates stimulation of large diameter sensory nerve fibers without creating significant muscle contraction. Such improvement is often accompanied by the abolishment of the pain with disappearance of local substance P and increase in local serotonin with disappearance of local L-tryptophan.

Meridian-like networks of internal organs, corresponding to traditional Chinese 12 main meridians and their acupuncture points as detected by the "Bi-Digital O-Ring Test imaging method": search for the corresponding internal organ of Western medicine for each meridian--Part I.

The "Bi-Digital O-Ring Test" imaging method has been successfully used not only to outline the internal organs but also malignant tumors as long as identical reference control tissue is available, regardless of whether it comes from the same individual or others, without exposing the patient to undesirable radiation from X-Rays, strong magnetic field or ultra-sound. While imaging the outline of the internal organs the author found that, from the surface of each organ, lines or networks of lines extend to other parts of the body. Such a line closely resembles well-known lines of meridians of major internal organs in Oriental medicine. This meridian-like network of each internal organ can be imaged using a microscopic slide, dessicated tissue or raw tissue of the same internal organ as reference control substance in "Bi-Digital O-Ring Test" imaging method. In previous papers, among meridians of 12 main internal organs in Traditional Chinese Medicine, the author was able to find which meridian corresponds to which internal organ of Western Medicine as in 10 meridians by "Bi-Digital O-Ring Test" imaging with corresponding internal organs as reference control substances, with the exception of "Pericardium Meridian", and "Triple Burner Meridian". In this study we were able to confirm that the "Pericardium Meridian" can be imaged mainly using adrenal gland as a reference control substance and "Triple Burner Meridian" can be imaged by the ovary or adrenal gland in the female and also can be imaged by the testes or adrenal gland in the male. Thus, the author was able to confirm, for the first time, the corresponding internal organ of Western Medicine for each one of the 12 main meridians. During this study, when actively imaging the meridian-like network, the author found bulging areas of the meridian-like network at specific locations, and found that these bulging areas correspond to specific acupuncture points. The area or average diameter of these acupuncture points often increased in the abnormal area and returned relatively small normal diameter by acupuncture given on certain acupuncture points of the same meridian. Thus, one can find the exact location of the meridian-like network and specific acupuncture points along the network. Therefore, it is now possible to re-evaluate true effects of giving acupuncture on these specific points as well as some of the other classical concepts of acupuncture.

Microbial infection or trauma at cardiovascular representation area of medulla oblongata as some of the possible causes of hypertension or hypotension.

The author found that the onset of hypertension or hypotension is relatively often associated with infections or development of so-called "sneezing due to allergy to pollen or dust," with or without headache, or due to trauma to the occipital area of the head. Using the "Bi-Digital O-ring Test," it was possible to demonstrate that, among bacterial and viral infections, the most common cause of infection associated with the appearance of hypertension is chlamydia, herpes simplex virus, cytomegalovirus, or Epstein-Barr virus. Particularly chlamydia and/or herpes simplex virus, with or without coexistence of other microbes, is usually present at the heart representation area of the medulla oblongata, especially at the left ventricular representation area, often accompanied by upper respiratory infection, cephalic, cervical or facial pain, with or without coexisting genito-urinary infection. The left ventricular representation area of the medulla oblongata is usually located at the right side. In most hypertensive patients, the left ventricular representation area of the medulla oblongata is enlarged up to 3 or 4 times normal size. Sufficient antibiotic treatment of chlamydia with erythromycin sometimes eliminated severe hypertension which appeared after chlamydia infection. In the presence of viral infections, such as herpes simplex, which is also causing severe pain in the head or neck, oral administration of acyclovir, erythromycin, or EPA (Eicosa Pentaenoic acid)-DHA (docosa hexaenoic acid) Omega 3 fish oil often reduced associated intractable pain and hypertension toward the normal level. Thus, the author is proposing new possible mechanisms as among the causes of so-called essential hypertension as a result of microbial infection or trauma of the cardiovascular representation area, particularly that of the left ventricular representation area at the right side of the medulla oblongata.

Impression on observing psychic surgery and healing in Brazil which appear to incorporate (+) qi gong energy & the use of acupuncture points.

In December, 1995, the author had the opportunity to observe an elderly psychic healer of East European origin in Sao Paulo, Brazil. This man specialized in cancer treatment by pointing with the fingers of his right hand at his patients, without actually touching them, spending an average of 30 to 40 minutes with each one. The author considered this to be Qi Gong treatment. In March, 1997 the author also observed 2 leading psychic healers in Brazil. One of them, named Rubens Farias, Jr. is a 43 year-old former engineer and computer programmer if European descent, who is commonly known as "Dr. Fritz III" because he is believed to be the spirit of Dr. Adolf Fritz, a German physician who died during World War I, operates through him. The other is "Dr." Hirota, a 53 year old former farmer of Japanese decent who lives near Campinas. About 120 kilometers outside of Sao Paulo and treats large numbers of people daily using indirect and/or hand-on healing techniques. On March 6, 1997, when the author visited "Dr. Fritz III"'s clinic in Sao Paulo with a group of Brazilian physicians, he was informed the about 1,400 patients had come that day. "Dr Fritz III" examined and treated the majority of the patients in less than one minute each, often asking very quick questions and then immediately beginning treatment. Most patients received injections of a dark-brown solution, which, some of the visiting doctors speculated, may be an iodine solution mixed with either alcohol or a local anesthetic. In many patients, he injected this solution near the pathological area or at an acupuncture point near the pathological area. When the needle of the syringe was in the acupuncture pint, he twirled it with his fingers several times and the withdrew it. Minor surgery was performed in about 1/5th of the patients with whom the author observed. Most of the surgical incisions were made on the midline of the tissue over the spine near the pathological area. The clamping of the blood vessels and the closings of the surgical wounds were performed by licensed surgeons or licensed nurses. Major surgery were done by "Dr. Fritz III" who used a rather primitive and unorthodox cutting technique. Except for major surgery, assistance was performed by volunteer nurses, including his wife. After the surgical wounds were closed, gauze band-aids were applied. When the surface of the gauze facing the wound was examined, it showed strong (+) Qi Gong energy according to the Bi-Digital O-Ring Test. Essentially, "Dr. Fritz III"'s treatment consists of acupuncture, injection of iodine with other substances near the pathological area, and (+) Qi Gong energy stored gauze which is applied to the acupuncture point, pathological area, or the site of surgery. "Dr." Hirota is another famous psychic healer whom the author was able to meet and observe in practice while in Brazil. "Dr." Hirota has been practicing for over 20 years. He usually sees patients who come to his clinic in the mornings and he claims to treat 1,000 to 2,000 patients daily between 9 AM and 12 noon. His main treatment also appears to be the application of external Qi Gong energy through the fingers of his right-hand, in combination with Shiatsu Massage and a manual procedure resembling chiropractic manipulation.

Transmission of molecular information through electro-magnetic waves with different frequencies and its application to non-invasive diagnosis of patients as well as detection from patient's X-ray film of visible and not visible medical information: Part I.

Our previous study indicates the principle that information on the molecular structure and its quantity will be transmitted bi-directionally through a red-spectrum soft laser beam when specific molecules are placed in the close vicinity of the laser beam. The method was immediately applied for diagnosing diseases or localizing specific substances, using the Bi-Digital O-Ring Test, in moving or stationary animals or human subjects at clearly visible distances, without directly contacting the subject. This principle was also applied for the microscopic Bi-Digital O-Ring Test to examine cellular structures and substances within the cell at the magnified focused projected plane. The method was further expanded to an electron-microscopic Bi-Digital O-Ring Test, where, instead of a light beam as a source of electromagnetic wave carrier, an electron beam was used. Thus, it was possible to study the ultra-fine structure of cells. During the past several years, the author has been experimenting with the question of whether, instead of using visible light in the microscopic Bi-Digital O-Ring Test, if much shorter wavelengths, such as X-ray with strong penetrating force through living tissue, are used as the carriers of molecular information, and if X-ray pictures of the body are evaluated by a similar method as in the microscopic Bi-Digital O-Ring Test, molecular information existing in the pathways of the X-ray through the body might be detectable or not. Our studies indicate that, using X-ray film with good picture quality taken of specific parts of the body, one can detect not only specific microbial infections, such as bacterial, viral, or spirochete (e.g., Lyme), and changes in local chemistry including blood chemistry such as glucose, total cholesterol, uric acid, in major arteries or the heart, but also potentially effective medication. Using the Bi-Digital O-Ring Test resonance phenomenon between a reference control substance and an identical substance or its electromagnetic field imprint, anatomical structures of the soft tissue, such as blood vessels, nerves, and muscles can be identified even when they are not visible on the X-ray film because of the masking effect of other tissues with high density or large volume of tissue. Similar findings were also found in the CAT Scan and MRI pictures of normal and abnormal organs of the body. In this paper, two examples of such analyses, i.e. X-ray films of one patient with adenocarcinoma of the colon and another patient with rheumatoid arthritis of the knee joint are shown.

Accurate localization of organ representation areas on the feet & hands using the bi-digital O-ring test resonance phenomenon: its clinical implication in diagnosis & treatment--Part I.

Accuracy of the widely used organ representation areas, currently used in different schools of foot and hand reflexology was evaluated using Bi-Digital O-Ring test resonance phenomenon. Our previous study indicated that mapping organ representation areas of the tongue using Bi-Digital O-Ring Test resonance phenomenon between 2 identical substances often provided more reliable clinical information for both diagnosis and treatment than the 2 widely used, but crude, traditional schools of Chinese tongue diagnosis. This same method was applied for the mapping of the organ representation areas on the feet and hands. We succeeded in mapping the following areas on human feet: 1) Middle (3rd) toe on the sole side represents the following starting from the tip: A) Head, B) Face with eye, ear, nose, and mouth (1st Digit) C) Neck and organs within the neck (narrow band of space between 1st crease after the 1st digit and crease at the junction of the beginning of the sole); 2) 2nd and 4th toe represent upper extremities, the beginning tip being fingers and hands. The crease at the base of these toes represents the shoulder. The 2nd toe represents right upper extremity, and the 4th toe represents left upper extremity; 3) 1st and 5th toes in both the right and left feet represent lower extremities with the tip being the toes and soles of feet. The crease at the base of these toes represents the inguinal area. The 1st toe of each foot represents right lower extremity, and 5th toe represents left lower extremity. The sole of the foot is divided into the following 3 distinctive sections. 1) Upper (1st) section represents organs in the chest cavity including 2 thymus glands, trachea, 2 lungs, with the heart between them, and with the esophagus appearing as a narrow band outside of the lung near and below the 1st and 2nd toe depending upon the individual. Chest section occupies the first 1/3 to 1/5 (on a relatively long foot) of the entire sole. The boundary between the chest and G.I. system can be approximately estimated by extending the length of the entire toe or up to 25% longer to the sole, but it can be accurately determined using a diaphragm tissue microscope slide as a reference control substance. 2) Middle (2nd) section represents Gastro-Intestinal system, including lower end of the esophagus, liver, stomach, spleen, gall bladder, pancreas, duodenum, jejunum, ileum, appendix, colon, and anus.(ABSTRACT TRUNCATED AT 400 WORDS)

Simple and quick non-invasive evaluation of circulatory condition of cerebral arteries by clinical application of the "Bi-Digital O-Ring Test".

Using the "Bi-Digital O-Ring Test," generalized abnormal circulation of the distribution of the 3 cerebral arteries at each side of the brain (i.e., anterior cerebral artery, middle cerebral artery and posterior cerebral artery) can be predicted, without any expensive instruments usually in a few minutes. When abnormality was found in the bifurcation area of the common carotid artery by the "Bi-Digital O-Ring Test," there were always abnormal findings of the area of the brain where circulation was coming from either one or both of the anterior or middle cerebral arteries. When abnormal "Bi-Digital O-Ring" response was found at the vertebral artery and posterior cerebral artery representation point, discovered by the author, at the side of the 6th cervical vertebra (corresponding to the entry point of the vertebral artery into the transverse foramen), the areas of the cerebrum, cerebellum and brain stem where circulation is coming from the posterior cerebral artery, basilar artery and vertebral artery were also abnormal. Most of these abnormalities were found to be associated with problems of the cervical vertebrae and spastic muscles of the neck and shoulders and are often reversible. In this study, the author was able to differentiate abnormal brain circulation of any major branch of arteries in the brain due to organic changes or functional reversible changes by relaxing these spastic muscles and improving the circulation of the neck and shoulder area by giving either manual acupuncture, massage, or transcutaneous electrical stimulation. This in turn often improved brain circulation. If it was a functional abnormality, within a few minutes after one of these procedures the "Bi-Digital O-Ring Test" usually showed normal response or improvement. However, if it was an organic abnormality, the abnormality remained. When the supra-orbital arterial blood pressure at both sides of the forehead decreases below 40 or 30 mmHg, most patients develop so-called "Cephalic Hypotension Syndrome," which is characterized by sleep disturbance pattern; difficulty in concentration; easy forgetfulness of recent events; irritability; decreased pain threshold with or without depression; spastic skeletal muscles, particularly the neck, shoulder and back areas. All of these symptoms can be explained by decreased circulation to the Nucleus Raphe Centralis Superior (controls sleep and waking pattern), Nucleus Raphe Magnus (serotonin & modulation of pain), Nucleus Reticularis Giganto Cellularis (controls muscle tone), etc. in reticular formation.(ABSTRACT TRUNCATED AT 400 WORDS)

Acupuncture points & use of moxibustion, found in the popular literature & paintings of 17th century Japan.

Acupuncture and moxibustion have long been an integral part of Far Eastern oriental medicine. Moxibustion and acupuncture cannot be discussed without each other since both use the same acupuncture point locations and nomenclatures. In the late 17th century, the famous travel diary of Basho, a Japanese master of haiku poetry, made reference to personal use of moxibustion on one of the well-known acupuncture points, stomach 36. Recently, the author found 2 paintings of a 17th century Kyoto geisha house and its surroundings in the Boston Museum of Fine Arts, painted in realistic color by Moronobu, the originator of the Ukiyoe style and a contemporary of Basho. Part of the scene depicts some professional porters at work; on their legs are white scars at some of the well-known acupuncture points, including stomach 36 and spleen 6. The scars appear to be the result of moxibustion. This may indicate the common use of moxibustion on well-known acupuncture points of the lower extremities in late 17th century Japan for professional porters and for people making extensive journeys. Further support of the relatively widespread use of acupuncture and moxibustion is even found in the popular, non-medical literature of late 17th century Japan. In one of the short stories about the life of average people, written by the novelist Saikaku, the details of a young woman giving moxibustion on the back of a young man is realistically described with illustrations. Reports written by some of the foreign physicians who visited Japan during this period were published, describing these methods with illustrations.(ABSTRACT TRUNCATED AT 250 WORDS)

Non-invasive circulatory evaluation and electro-acupuncture & TES treatment of diseases difficult to treat in Western medicine.

Even in the presence of normal blood pressure (B.P.) in both arms in some individuals, abnormal B.P. and circulatory disturbances can be found in the brain and lower extremities. The author discovered the following five types of abnormal B.P. in the brain in the presence or absence of normal B.P. in the arms: unilateral cephalic hypertension; bilateral cephalic hypertension; unilateral cephalic hypotension; bilateral cephalic hypotension; mixed cephalic hypertension and hypotension. When the B.P. of the head exceeds about 160 mm Hg, patients experience sensation of increased pressure buildup in the head to moderate headache. When it exceeds over 220 mm Hg, most of them experience severe headache in that side of the head. When the B.P. is very low (less than 30 mm Hg in both sides), majority of the subjects experience sleep disturbance pattern, mainly insomnia and some develop excessive sleepiness; difficulty in concentration and easy forgetfulness of recent events; various degrees of irritability. They are often associated with injury of neck-shoulder area with the presence of spastic muscles in the area. Relaxation of the spastic muscles by acupuncture, TES or soft laser beam from He-Ne (7 approximately 15m Watts) often change the abnormal cephalic B.P. toward normal. Among individuals with cephalic hypotension some of them develop eye problems. Blind patients with macular degeneration and retinitis pigmentosa often have severe cephalic hypotension and reduced blood flow. Improvement of B.P. and blood flow induced by safe and effective electrical stimulation resulted in significant improvement in vision. In some patients, abnormal B.P. and blood flow of the brain are dependent on the position of the head and neck which can be classified as "Cephalo-cervical Position Dependent Dysfunction Syndrome" which interferes with the function of some of the internal organs. In many psychiatric patients with schizophrenia or severe depression, cephalic B.P. and blood flow are often reduced significantly with additional abnormal function of pancreas, thyroid gland or liver. These abnormalities can explain some of the abnormal behavior, particularly when hypoglycemia, decrease in serotonin level and decreased circulation in the brain coexist.(ABSTRACT TRUNCATED AT 400 WORDS)

New simple early diagnostic methods using Omura's "Bi-Digital O-Ring Dysfunction Localization Method" and acupuncture organ representation points, and their applications to the "drug & food compatibility test" for individual organs and to auricular diagnosis of internal organs--part I.

By critically evaluating exceptions which may lead to false diagnoses, as well as by improving the currently-used applied kinesiology diagnostic method (="Dysfunction Localization Method"), the author was able to develop the "Thumb-Index Finger Bi-Digital O-Ring Diagnostic Method," using the Applied Kinesiology Dysfunction Localization Principle. By combining the author's "Bi-Digital O-Ring Dysfunction Localization Method" with clinically useful organ representation points in acupuncture medicine (where the presence of tenderness at the organ representation point is used for diagnosis as well as for the location of treatment), it has become possible to make early diagnoses of most of the internal organs, with an average diagnostic accuracy of over 85%, without knowing the patient's history or using any instruments. The method can detect dysfunctioning or diseased organs even before tenderness appears at the organ representation point, with an applied force of less than 1 gm/mm2 on the skin surface, while the detection of tenderness at the organ representation point often requires a minimum applied force of 80-100 gm/mm2. The method was applied to the "Drug and Food Compatibility Test" to determine the probable effects of a given food or drug on individual internal organs without going through time-consuming, expensive laboratory tests. It was also applied to auricular organ representation points and their evaluation, and has succeeded in increasing their diagnostic sensitivity. The method was also used for the evaluation of magnetic fields. Usually the North pole increased muscle strength and the South pole weakened it at most parts of the body. This simple, improved, economical diagnostic method may have invaluable implications in clinical diagnosis, treatment and drug research. Key Words: early diagnostic methods, "Thumb-Index Finger Bi-Digital O-Ring Diagnostic Method," applied kinesiology, cardio-vascular diseases, drugs, tenderness, pain, pain medicine, anti-hypertensive drugs, cardio-vascular drugs, aspirin, Bufferin, gastro-intestinal system, muscle strength, nutrition, magnetic field, sensory nerve, spinal cord, brain stem. Inderal.

Accurate localization of organ representation areas of the tongue, using the Bi-Digital O-Ring Test: its clinical application, and re-evaluation of classical Oriental tongue diagnosis--Part I.

In spite of the importance of tongue diagnosis in Oriental Medicine, a very rough assignment of only a limited number of the major internal organs is known, and some of the assignments are not exactly the same, depending upon various schools of thought. In 1980, the author first developed a simple, quick, non-invasive, accurate method of localizing representation areas of internal organs, using the Bi-Digital O-Ring Test Molecular Identification Method based on the resonance phenomena between 2 identical substances or tissues, with a microscope slide of a specific internal organ as a reference control substance. The method was applied to the organ representation areas in the ears, hands, feet, cerebral cortex, and tongue. In this article for the first time detailed organ representation areas of the human tongue are being presented in comparison with currently known organ representation areas on the tongue. For convenience, the tongue can be divided into 3 parts: the anterior, the middle, and the posterior. On each side of the anterior part (1st part, area around the tip) of the tongue, the internal organs in the chest cavity are represented; from the mid-line to each side of the tip of the tongue, the oesophagus, thymus gland, lung (and trachea & bronchi), heart, and breast (over heart area) are represented. The middle (2nd) part of the tongue represents the digestive system, and the 3rd part represents the genito-urinary system. The 2nd part of the tongue represents the rectum, colon, cecum, appendix, small intestine, stomach, pancreas, liver, and gall bladder. The 2nd and 3rd parts of the tongue represent all the internal organs in the abdominal cavities and the genito-urinary area. The remaining one-third of the tongue, near the pharynx, is all related to the genito-urinary system with the exception of the spleen, which is located between the kidney and the adrenal gland representation areas. Within the triangular area formed by the sulcus terminalis, the anus is represented on both sides. Finally, at the peak of that triangle, i.e. the foramen cecum, the coccyx is represented. Extremities are represented at the sides of the tongue. The undersurface of the tongue starting from the tip of the tongue in the mid-line and going towards the root of the tongue along the frenulum in the mouth represents one kind of homunculus consisting of the neck, face, head, ears, upper & lower extremities and back of the body.(ABSTRACT TRUNCATED AT 400 WORDS)

Simple non-invasive early detection and localization of specific cancer tissues of internal organs and differentiation of cancer tissue from surrounding areas infected by cancer related viruses, as well as evaluation of their micro-circulatory condition & drug uptake using the BI-Digital O-Ring Test.

In 1984, the author first developed a simple, quick, non-invasive, economical method of detecting cancer in specific internal organs, using the Bi-Digital O-Ring Test (BDORT), with a microscope slide of specific cancer of a specific internal organ as a reference control substance. The detection rate for cancer screening was much greater than with any standard diagnostic tests. When imaging was performed using the BDORT, the area of positive response to the cancer positive slide was often much greater than the actual size of the cancer itself. This was due to the fact that most of the cancer tissue of the lungs or digestive system contained viruses such as HTLV-3 (often found in adenocarcinoma of the lung, stomach, head of pancreas, and colon) or HTLV-1 (often found in small-cell carcinoma of the lung and certain types of leukemia). The extent of the virus positive area was often far greater than that of the cancer tissue itself and was distributed in a much greater area surrounding the cancer. For this reason, the virus alone showed a response which could be mistaken for cancer tissue. The author succeeded in differentiating the exact location of cancer tissue itself from surrounding cancer related virus (with or without other microbes) positive area by using a pair of identical microscope slides with the same cancer tissue. One of the slides was exposed to ultra-violet rays (peak wavelength of 253.7 nm mercury vapor atomic resonance spectral line) for 40 seconds-4 minutes. After this exposure, the BDORT response to the virus (with or without other microbes) associated with the cancer tissue was completely eliminated, while the response to the cancer tissue was maintained. Using an ultraviolet exposed cancer slide, the imaging of the part of the body which responded to this virus-free cancer slide indicated the actual location of the cancer tissue, which was often confirmed by standard X-ray or other imaging methods when the thickness of the tumor was relatively large. These cancers detectable by standard laboratory tests had strikingly weakening response to the BDORT (-3.5 and -4), with ultra-violet exposed cancer slide as well as for antibody of Oncogen C-fos. The smallest size of cancer tissue detected by this method was less than 1mm in diameter in the very early stage of the cancer, which usually cannot be detected by current laboratory tests.(ABSTRACT TRUNCATED AT 400 WORDS)

Storing of qi gong energy in various materials and drugs (qi gongnization): its clinical application for treatment of pain, circulatory disturbance, bacterial or viral infections, heavy metal deposits, and related intractable medical problems by selectively enhancing circulation and drug uptake.

In the process of evaluating the effects of external Qi Gong on inanimate substances by the Bi-Digital O-Ring Test, Qi Gong energy was shown to have a polarity which the author designated for convenience sake (+) or (-), where (+) increases the strength of muscles and (-) weakens them. Depending upon how external Qi Gong is applied and from which part of the body it emanates, the polarity changes. In general, it was found that, when (+) polarity is applied to the painful area or spastic muscles or arteries in vaso-constriction it often reduced or eliminated the pain, spastic muscles or circulatory disturbances. The author succeeded in storing part of the Qi Gong energy in inanimate materials, such as papers, metals (such as a sheet of aluminum foil), glass, stone, band-aids, clothes, drugs, etc. in bi-polar (one end of the same material becomes (+) polarity and the other end of the same material becomes (-) polarity) form in one material or uni-polar, i.e., the entire material either has pure (+) polarity or (-) polarity. Water, EPA, vitamins, antibiotics and other drugs were also converted to (+) polarity. When the material has a bi-polar state, it becomes possible to eliminate one of the polarities by applying certain changing electrical fields. The effect of placing (+) polarity Qi Gong energy stored material was compared with direct application of the Qi Gong on pain, spastic muscle and spastic vertebral arteries. The therapeutic effects of these 2 methods were quite similar for the identical time duration but a more predictable effect was often obtained in the former. As our previous study indicates that acupuncture, electrical stimulation (1-3 pulses/sec.), as well as Qi Gong not only improved the microcirculatory disturbance and relaxed spastic muscles and vaso-constrictive arteries but also reduced or eliminated the pain and also selectively enhanced drug uptake to the area where drugs could not be delivered due to existing circulatory disturbances, by placing (+) Qi Gong stored material, such as a sheet of paper or aluminum foil, band-aid or clothes. Bi- Digital O-Ring Test evaluation indicated that not only did it produce all the beneficial effects of Qi Gong but also enhanced the drug uptake selectively in the area where it is necessary for the drug to be delivered for effective treatment, and reduced lead deposits in tissue.(ABSTRACT TRUNCATED AT 400 WORDS)