Non-contact widefield neonatal retinal imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging.

OBJECTIVE: To illustrate the role of non-contact widefield retinal imaging (NC-WFI) of retinopathy of prematurity (ROP) using the Clarus 700 high resolution true colour reflectance imaging. METHODS: All babies were examined by the vitreoretinal faculty in a tertiary eye care centre from a period of March 2021 to November 2021 using the indirect ophthalmoscope after pupillary dilatation. ROP grading was done according to the revised ICROP (2005) classification. NC-WFI was then performed using the Clarus 700 high resolution true colour reflectance imaging (Carl Zeiss Meditec, Dublin, CA) in the retina diagnostic set up of a tertiary eye care centre. RESULTS: A total of 22 babies (44 eyes) underwent NC-WFI from March 2021 to November 2021. 13 unique cases of retinopathy of prematurity with images captured on Clarus 700 and the clinical summary is described. CONCLUSION: Clarus is a non-contact wide field imaging (NC-WFI) system that can capture high resolution and true colour images (images of the fundus appear similar colour to direct observation by ophthalmoscopy) helping in more accurate diagnosis and grading of the severity of ROP.

Netarsudil-induced corneal honeycombing in childhood glaucomas.

Netarsudil is a hypotensive drug that reduces intraocular pressure (IOP). Although it is used to treat corneal decompensation/edema in normotensive eyes, we observed the occurrence of corneal epithelial edema with corneal honeycombing in children with uncontrolled IOP (primary or secondary glaucoma) on maximal topical medication following netarsudil (0.02%) therapy of >2 weeks. Of 16 eyes of 16 children, 9 (56%) developed corneal honeycombing. They were younger than those without honeycombing (median age, 3.1 vs 9.7 years [P = 0.016]), had higher baseline IOP (35.6 ± 7.4 vs 27.2 ± 5.6 mm Hg [P < 0.001]), and usually had preexisting corneal edema (7/9 eyes vs none [P < 0.001]).

The effect of two lighting conditions on performance of the Farnsworth Lantern color vision test.

This paper compares the performance of color defective patients on the Farnsworth Lantern test in both unlit and lit room conditions. We examined 18 dichromats and 33 anomalous trichromats, as diagnosed by the Mark I Nagel Anomaloscope. No statistically significant differences were found between their performance in the two conditions.

Pediatric eye disease investigator group amblyopia treatment review.

INTRODUCTION: The Pediatric Eye Disease Investigator Group (PEDIG), formed in 1997, has been dedicated to clinical research of eye diseases affecting children. Over the last three years, PEDIG has studied the efficacy of amblyopia treatment regimes, and has followed the long-term outcomes of these regimes. These studies are known as the Amblyopia Treatment Studies (ATS) and have been sorted into eight categories. Four of these have been published and four are still awaiting publication. METHOD: A survey of ophthalmologists and orthoptists attending a seminar in British Columbia, Canada. They were questioned as to how they treat amblyopia in light of the PEDIG studies. RESULTS: Ninety percent continue to use patching as their first method of treatment in moderate amblyopia. Over 50% will patch four hours/day or more to begin treatment and 83% will use near exercises to augment the patching. Two thirds will begin patching six or more hours/day in patients with severe amblyopia. Those that use atropine, use it daily rather than on weekends. Most felt that amblyopia could be treated to age 12 years and some thought it could be treated to 14 years. CONCLUSION: Most ophthalmologists and orthoptists taking the survey have not significantly changed their approach to amblyopia treatment in light of the recent PEDIG studies.

Sensitivity and specificity of tests to detect eye disease in an older population.

OBJECTIVE: To compare the ability of tests of visual function to detect the presence of eye disease. DESIGN: Cross-sectional study. PARTICIPANTS: Three thousand six hundred fifty-four of 4433 (82.4%) eligible residents of an area near Sydney aged 49 years and older had a detailed eye examination, including retinal and lens photography and subsequent grading of eye disease, tests of presenting and corrected visual acuity, contrast sensitivity, screening visual field and intraocular pressure. MAIN OUTCOME MEASURES: Receiver operator characteristic (ROC) curves were created and area under the curve compared for each vision test. Sensitivity and specificity were calculated for each test. RESULTS: No single vision test predicted the presence of eye disease with any consistency. Best-corrected visual acuity or contrast sensitivity had the highest area under the ROC curve for most eye diseases examined but had poor sensitivity and specificity. For glaucoma and diabetic retinopathy there was no difference in area under the curve for any of the tests examined, and no test had a good balance of sensitivity and specificity. Screening tests (performed with presenting correction) did not perform as well as nonscreening tests (those carried out after refraction with best correction). CONCLUSIONS: Current vision tests are not particularly good at detecting eye disease compared with the "gold standard" of a full eye examination performed by an ophthalmologist. Further work in this area should be carried out before vision screening programs can be recommended for implementation among older people.