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1.

Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy.

Dolton, Garry; Rius, Cristina; Wall, Aaron; Szomolay, Barbara; Bianchi, Valentina; Galloway, Sarah A E; Hasan, Md Samiul; Morin, Théo; Caillaud, Marine E; Thomas, Hannah L; Theaker, Sarah; Tan, Li Rong; Fuller, Anna; Topley, Katie; Legut, Mateusz; Attaf, Meriem; Hopkins, Jade R; Behiry, Enas; Zabkiewicz, Joanna; Alvares, Caroline; Lloyd, Angharad; Rogers, Amber; Henley, Peter; Fegan, Christopher; Ottmann, Oliver; Man, Stephen; Crowther, Michael D; Donia, Marco; Svane, Inge Marie; Cole, David K; Brown, Paul E; Rizkallah, Pierre; Sewell, Andrew K.

Cell; 186(16): 3333-3349.e27, 2023 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-37490916

2.

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel.

Gökbuget, Nicola; Boissel, Nicolas; Chiaretti, Sabina; Dombret, Hervé; Doubek, Michael; Fielding, Adele; Foà, Robin; Giebel, Sebastian; Hoelzer, Dieter; Hunault, Mathilde; Marks, David I; Martinelli, Giovanni; Ottmann, Oliver; Rijneveld, Anita; Rousselot, Philippe; Ribera, Josep; Bassan, Renato.

Blood; 143(19): 1891-1902, 2024 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-38295337

3.

Management of ALL in adults: 2024 ELN recommendations from a European expert panel.

Gökbuget, Nicola; Boissel, Nicolas; Chiaretti, Sabina; Dombret, Hervé; Doubek, Michael; Fielding, Adele; Foà, Robin; Giebel, Sebastian; Hoelzer, Dieter; Hunault, Mathilde; Marks, David I; Martinelli, Giovanni; Ottmann, Oliver; Rijneveld, Anita; Rousselot, Philippe; Ribera, Josep; Bassan, Renato.

Blood; 143(19): 1903-1930, 2024 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-38306595

4.

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation.

Chiriches, Claudia; Nicolaisen, Nathalie; Wieske, Maria; Elhaddad, Heba; Mehmetbeyoglu, Ecmel; Alvares, Caroline; Becher, Dörte; Hole, Paul; Ottmann, Oliver Gerhard; Ruthardt, Martin.

PLoS Genet; 18(10): e1010463, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-36288392

5.

Phase Ib study of sabatolimab (MBG453), a novel immunotherapy targeting TIM-3 antibody, in combination with decitabine or azacitidine in high- or very high-risk myelodysplastic syndromes.

Brunner, Andrew M; Esteve, Jordi; Porkka, Kimmo; Knapper, Steve; Traer, Elie; Scholl, Sebastian; Garcia-Manero, Guillermo; Vey, Norbert; Wermke, Martin; Janssen, Jeroen J W M; Narayan, Rupa; Fleming, Shaun; Loo, Sun; Tovar, Natalia; Kontro, Mika; Ottmann, Oliver G; Naidu, Purushotham; Sun, Haiying; Han, May; White, Roisin; Zhang, Na; Mohammed, Anisa; Sabatos-Peyton, Catherine A; Steensma, David P; Rinne, Mikael L; Borate, Uma M; Wei, Andrew H.

Am J Hematol; 99(2): E32-E36, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-37994196

6.

Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.

Hughes, Timothy P; Mauro, Michael J; Cortes, Jorge E; Minami, Hironobu; Rea, Delphine; DeAngelo, Daniel J; Breccia, Massimo; Goh, Yeow-Tee; Talpaz, Moshe; Hochhaus, Andreas; le Coutre, Philipp; Ottmann, Oliver; Heinrich, Michael C; Steegmann, Juan L; Deininger, Michael W N; Janssen, Jeroen J W M; Mahon, Francois-Xavier; Minami, Yosuke; Yeung, David; Ross, David M; Tallman, Martin S; Park, Jae H; Druker, Brian J; Hynds, David; Duan, Yuyan; Meille, Christophe; Hourcade-Potelleret, Florence; Vanasse, K Gary; Lang, Fabian; Kim, Dong-Wook.

N Engl J Med; 381(24): 2315-2326, 2019 12 12.

Artículo en Inglés | MEDLINE | ID: mdl-31826340

7.

Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia.

Chiriches, Claudia; Khan, Dilawar; Wieske, Maria; Guillen, Nathalie; Rokicki, Michal; Guy, Carol; Wilson, Marieangela; Heesom, Kate J; Ottmann, Oliver Gerhard; Ruthardt, Martin.

Ann Hematol; 101(10): 2179-2193, 2022 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-35941390

8.

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat.

Oppliger Leibundgut, Elisabeth; Haubitz, Monika; Burington, Bart; Ottmann, Oliver G; Spitzer, Gary; Odenike, Olatoyosi; McDevitt, Michael A; Röth, Alexander; Snyder, David S; Baerlocher, Gabriela M.

Haematologica; 106(9): 2397-2404, 2021 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-32732354

9.

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1^T315I and BCR-ABL1^T315I-E255K.

Mian, Afsar Ali; Haberbosch, Isabella; Khamaisie, Hazem; Agbarya, Abed; Pietsch, Larissa; Eshel, Elizabeh; Najib, Dally; Chiriches, Claudia; Ottmann, Oliver Gerhard; Hantschel, Oliver; Biondi, Ricardo M; Ruthardt, Martin; Mahajna, Jamal.

Ann Hematol; 100(8): 2023-2029, 2021 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-34110462

10.

Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome-positive B-precursor acute lymphoblastic leukemia.

Rambaldi, Alessandro; Ribera, Josep-Maria; Kantarjian, Hagop M; Dombret, Hervé; Ottmann, Oliver G; Stein, Anthony S; Tuglus, Catherine A; Zhao, Xiaoyue; Kim, Christopher; Martinelli, Giovanni.

Cancer; 126(2): 304-310, 2020 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-31626339

11.

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.

Legut, Mateusz; Dolton, Garry; Mian, Afsar Ali; Ottmann, Oliver G; Sewell, Andrew K.

Blood; 131(3): 311-322, 2018 01 18.

Artículo en Inglés | MEDLINE | ID: mdl-29122757

12.

Genomic CDKN2A/2B deletions in adult Ph⁺ ALL are adverse despite allogeneic stem cell transplantation.

Pfeifer, Heike; Raum, Katharina; Markovic, Sandra; Nowak, Verena; Fey, Stephanie; Obländer, Julia; Pressler, Jovita; Böhm, Verena; Brüggemann, Monika; Wunderle, Lydia; Hüttmann, Andreas; Wäsch, Ralph; Beck, Joachim; Stelljes, Matthias; Viardot, Andreas; Lang, Fabian; Hoelzer, Dieter; Hofmann, Wolf-Karsten; Serve, Hubert; Weiss, Christel; Goekbuget, Nicola; Ottmann, Oliver G; Nowak, Daniel.

Blood; 131(13): 1464-1475, 2018 03 29.

Artículo en Inglés | MEDLINE | ID: mdl-29348129

13.

Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.

Kroschinsky, Frank; Middeke, Jan Moritz; Janz, Martin; Lenz, Georg; Witzens-Harig, Mathias; Bouabdallah, Reda; La Rosée, Paul; Viardot, Andreas; Salles, Gilles; Kim, Seok Jin; Kim, Tae Min; Ottmann, Oliver; Chromik, Joerg; Quinson, Anne-Marie; von Wangenheim, Ute; Burkard, Ute; Berk, Andreas; Schmitz, Norbert.

Invest New Drugs; 38(5): 1472-1482, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32172489

14.

Hematopoietic stem cell involvement in BCR-ABL1-positive ALL as a potential mechanism of resistance to blinatumomab therapy.

Nagel, Inga; Bartels, Marius; Duell, Johannes; Oberg, Hans-Heinrich; Ussat, Sandra; Bruckmueller, Henrike; Ottmann, Oliver; Pfeifer, Heike; Trautmann, Heiko; Gökbuget, Nicola; Caliebe, Almuth; Kabelitz, Dieter; Kneba, Michael; Horst, Heinz-August; Hoelzer, Dieter; Topp, Max S; Cascorbi, Ingolf; Siebert, Reiner; Brüggemann, Monika.

Blood; 130(18): 2027-2031, 2017 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-28827408

15.

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

Baerlocher, Gabriela M; Oppliger Leibundgut, Elisabeth; Ottmann, Oliver G; Spitzer, Gary; Odenike, Olatoyosi; McDevitt, Michael A; Röth, Alexander; Daskalakis, Michael; Burington, Bart; Stuart, Monic; Snyder, David S.

N Engl J Med; 373(10): 920-8, 2015 Sep 03.

Artículo en Inglés | MEDLINE | ID: mdl-26332546

16.

Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL.

Rousselot, Philippe; Coudé, Marie Magdelaine; Gokbuget, Nicola; Gambacorti Passerini, Carlo; Hayette, Sandrine; Cayuela, Jean-Michel; Huguet, Françoise; Leguay, Thibaut; Chevallier, Patrice; Salanoubat, Celia; Bonmati, Caroline; Alexis, Magda; Hunault, Mathilde; Glaisner, Sylvie; Agape, Philippe; Berthou, Christian; Jourdan, Eric; Fernandes, José; Sutton, Laurent; Banos, Anne; Reman, Oumedaly; Lioure, Bruno; Thomas, Xavier; Ifrah, Norbert; Lafage-Pochitaloff, Marina; Bornand, Anne; Morisset, Laure; Robin, Valérie; Pfeifer, Heike; Delannoy, Andre; Ribera, Josep; Bassan, Renato; Delord, Marc; Hoelzer, Dieter; Dombret, Herve; Ottmann, Oliver G.

Blood; 128(6): 774-82, 2016 08 11.

Artículo en Inglés | MEDLINE | ID: mdl-27121472

17.

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia.

Rafiei, Anahita; Mian, Afsar Ali; Döring, Claudia; Metodieva, Anna; Oancea, Claudia; Thalheimer, Frederic B; Hansmann, Martin Leo; Ottmann, Oliver Gerhard; Ruthardt, Martin.

PLoS Genet; 11(4): e1005144, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25919613

18.

TKI vs relapse after HSCT: is the jury still out?

Ottmann, Oliver G.

Blood; 136(15): 1705-1706, 2020 10 08.

Artículo en Inglés | MEDLINE | ID: mdl-33031524

19.

Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma.

Oelsner, Sarah; Friede, Miriam E; Zhang, Congcong; Wagner, Juliane; Badura, Susanne; Bader, Peter; Ullrich, Evelyn; Ottmann, Oliver G; Klingemann, Hans; Tonn, Torsten; Wels, Winfried S.

Cytotherapy; 19(2): 235-249, 2017 02.

Artículo en Inglés | MEDLINE | ID: mdl-27887866

20.

The hypomorphic TERT A1062T variant is associated with increased treatment-related toxicity in acute myeloid leukemia.

Both, Anna; Krauter, Jürgen; Damm, Frederik; Thol, Felicitas; Göhring, Gudrun; Heuser, Michael; Ottmann, Oliver; Lübbert, Michael; Wattad, Mohammed; Kanz, Lothar; Schlimok, Günter; Raghavachar, Aruna; Fiedler, Walter; Kirchner, Hartmut; Brugger, Wolfram; Schlegelberger, Brigitte; Heil, Gerhard; Ganser, Arnold; Wagner, Katharina.

Ann Hematol; 96(6): 895-904, 2017 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-28331964

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