Detalles de la búsqueda
1.
Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
Am J Physiol Renal Physiol;
315(1): F57-F73, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29537311
2.
TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Proc Natl Acad Sci U S A;
112(47): E6486-95, 2015 Nov 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26604306
3.
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Antimicrob Agents Chemother;
60(5): 2822-33, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26902771
4.
Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines.
J Biomed Sci;
22: 57, 2015 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-26184865
5.
Small-molecule inducers of Aß-42 peptide production share a common mechanism of action.
FASEB J;
26(12): 5115-23, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22972917
6.
Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer.
Eur J Med Chem;
261: 115797, 2023 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37708799
7.
Targeting low molecular weight cyclin E (LMW-E) in breast cancer.
Breast Cancer Res Treat;
132(2): 575-88, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21695458
8.
Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules.
Eur J Med Chem;
240: 114578, 2022 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35841881
9.
Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography.
Bioconjug Chem;
21(2): 279-88, 2010 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-20092293
10.
Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.
Sci Rep;
10(1): 10983, 2020 Jul 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32620926
11.
A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.
Sci Rep;
10(1): 1143, 2020 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31980673
12.
Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation.
Front Neurol;
10: 124, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30915013
13.
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
Sci Rep;
9(1): 6653, 2019 04 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-31040306
14.
Recent advances in the development of cyclin-dependent kinase 7 inhibitors.
Eur J Med Chem;
183: 111641, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31514062
15.
A ß-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy.
Eur J Med Chem;
158: 1-6, 2018 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30199702
16.
A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?
ACS Omega;
2(7): 3467-3474, 2017 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-30023695
17.
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.
Eur J Med Chem;
125: 696-709, 2017 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27721154
18.
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.
J Innate Immun;
8(4): 330-49, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26987072
19.
Specific Triazine Herbicides Induce Amyloid-ß42 Production.
J Alzheimers Dis;
54(4): 1593-1605, 2016 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27589520
20.
Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell-based assays.
Nat Prod Res;
29(11): 1026-34, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25423141