RESUMEN
CONCLUSIONS: The results of this preliminary study demonstrate that with regard to determining the efficacy of intratympanic (IT) gentamicin treatment in patients with Meniere's disease, the reliability of testing for vestibular evoked myogenic potentials (VEMPs) is comparable to that of caloric tests. Compared with caloric tests, VEMP measurements are more comfortable and take less time. The results of VEMP and caloric testing do not correlate with the results of hearing tests. OBJECTIVE: To test the reliability of VEMP testing to monitor the results of IT gentamicin therapy in patients with Meniere's disease. SUBJECTS AND METHODS: Twelve patients with unilateral Meniere's disease were evaluated with pure tone audiometry (PTA), bithermal caloric tests, and VEMP tests. Patients with measurable caloric and VEMP results before IT gentamicin treatment were included in the study. IT gentamicin (0.5 ml) at a concentration of 40 mg/ml was administered to the patients. Reinjection was performed 10 days later depending on patients' complaints. Patients were re-evaluated with short- and long-term VEMP, hearing, and caloric test results. RESULTS: Caloric responses and VEMPs changed following gentamicin therapy in 9 patients and 12 patients, respectively. Long-term results of caloric and VEMP tests in patients receiving IT gentamicin treatment changed in 7 patients and 10 patients, respectively.
Asunto(s)
Potenciales Evocados Somatosensoriales/fisiología , Gentamicinas/administración & dosificación , Enfermedad de Meniere/tratamiento farmacológico , Inhibidores de la Síntesis de la Proteína/administración & dosificación , Vestíbulo del Laberinto/fisiopatología , Adulto , Audiometría de Tonos Puros , Relación Dosis-Respuesta a Droga , Potenciales Evocados Somatosensoriales/efectos de los fármacos , Femenino , Estudios de Seguimiento , Humanos , Inyecciones , Masculino , Enfermedad de Meniere/diagnóstico , Enfermedad de Meniere/fisiopatología , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento , Membrana Timpánica , Pruebas de Función Vestibular , Vestíbulo del Laberinto/efectos de los fármacosRESUMEN
A 42-year-old man presented with sensorineural hearing loss of acute onset, tinnitus, and vertigo. Physical examination revealed slight asymmetry in facial nerve functions and spontaneous nystagmus. Magnetic resonance imaging of the internal acoustic canal showed contrast enhancement consistent with edema-inflammation, being notable and diffuse in the seventh and eighth cranial nerve complex, and minimal in the cochlea. Non-hydropic cochleovestibular syndrome was considered and the patient was treated with antiviral and corticosteroid medications. A week later, facial paralysis improved and the acute hearing loss reversed. On the twelfth day of presentation, he had no complaints other than mild imbalance on abrupt changes in movement. In this type of herpetic facial paralysis in which cochleovestibular symptoms outweigh facial nerve symptoms, it might be argued that varicella zoster virus reactivation occurs in the spiral and/or vestibular ganglion.
Asunto(s)
Herpes Zóster Ótico/diagnóstico , Herpesvirus Humano 3/fisiología , Enfermedades del Laberinto/virología , Corticoesteroides/uso terapéutico , Adulto , Antivirales/uso terapéutico , Parálisis de Bell/diagnóstico , Parálisis de Bell/tratamiento farmacológico , Parálisis de Bell/fisiopatología , Pérdida Auditiva Sensorineural/virología , Herpes Zóster Ótico/tratamiento farmacológico , Herpes Zóster Ótico/fisiopatología , Humanos , Enfermedades del Laberinto/tratamiento farmacológico , Imagen por Resonancia Magnética , Masculino , Nistagmo Patológico , Canales Semicirculares/patología , Acúfeno/virología , Resultado del Tratamiento , Vértigo/virología , Activación ViralRESUMEN
OBJECTIVE: Although sensorineural hearing loss has been widely investigated in those with rheumatoid arthritis, studies assessing the vestibular system in patients with rheumatoid arthritis are limited. The aim of this study was to assess the vestibular system in patients with rheumatoid arthritis. METHODS: The study consisted of 43 patients with rheumatoid arthritis and 30 healthy controls. Otorhinolaryngologic and neurotologic examinations, pure-tone audiometry, impedancemetry, electronystagmography including smooth pursuit, saccade, positional, and caloric tests were performed in all patients with rheumatoid arthritis and in controls. The erythrocyte sedimentation rate, C-reactive protein level, and rheumatoid factor level were evaluated in all patients with rheumatoid arthritis. RESULTS: Audiograms revealed sensorineural hearing loss in 12 patients (27.9%) with rheumatoid arthritis and in two controls (6.6%); the difference was statistically significant (P=.033). In those with rheumatoid arthritis, the results of electronystagmography revealed central abnormalities in nine patients (20.9%), peripheral abnormalities in three (6.9%), and mixed abnormalities in three (6.9%). Smooth pursuit and saccade tracing impairments were significantly higher in patients with rheumatoid arthritis (P>.05). Canal paresis in patients with rheumatoid arthritis were significantly higher than those in the control group (P=.039). No association was found between electronystagmographic abnormalities in patients with rheumatoid arthritis and age, sex, duration of disease, the results of laboratory testing, sensorineural hearing loss, or medication use. CONCLUSION: Our results suggest an association of rheumatoid arthritis with vestibular system dysfunction as well as auditory impairment.
Asunto(s)
Artritis Reumatoide/fisiopatología , Electronistagmografía , Vestíbulo del Laberinto/fisiopatología , Pruebas de Impedancia Acústica , Adulto , Artritis Reumatoide/diagnóstico , Audiometría de Tonos Puros , Femenino , Pérdida Auditiva Sensorineural/diagnóstico , Pérdida Auditiva Sensorineural/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Seguimiento Ocular Uniforme/fisiología , Reflejo Acústico , Movimientos Sacádicos/fisiología , Enfermedades Vestibulares/diagnóstico , Enfermedades Vestibulares/fisiopatología , Pruebas de Función VestibularRESUMEN
Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world. To improve the approach pertaining to the diagnosis and management of middle ear cholesteatoma, clear, clinically applicable, and useful definition and classification of cholesteatoma are required. This review aimed to evaluate the current and most accepted descriptions and opinions concerning cholesteatoma. A review of the literature concerning different definitions and classifications of cholesteatoma was used in the preparation of the Cholesteatoma Guidelines, a project implemented by the European Academy of Otology - Neuro-otology.
Asunto(s)
Colesteatoma del Oído Medio/clasificación , Humanos , Medical Subject Headings , Terminología como AsuntoRESUMEN
The European Academy of Otology and Neurotology (EAONO) has previously published a consensus document on the definitions and classification of cholesteatoma. It was based on the Delphi consensus methodology involving the broad EAONO membership. At the same time, the Japanese Otological Society (JOS) had been working independently on the "Classification and Staging of Cholesteatoma." EAONO and JOS then decided to collaborate and produce a joint consensus document. The EAONO/JOS joint consensus on "Definitions, Classification and Staging of Middle Ear Cholesteatoma" was formally presented at the 10th International Conference on Cholesteatoma and Ear Surgery in Edinburgh, June 5-8, 2016. The international otology community who attended the consensus session was given the chance to debate and give their support or disapproval. The statements on the "Definitions of Cholesteatoma" received 89% approval. The "Classification of Cholesteatoma" received almost universal approval (98%). The "EAONO/JOS Staging System on Middle Ear Cholesteatoma" had a majority of approval (75%). Some international otologists wanted to see more prognostic factors being incorporated in the staging system. In response to this, the EAONO/JOS steering group plans to set up an "International Otology Outcome Working Group" to work on a minimum common otology data set that the international otology community can use to evaluate their surgical outcome. This will generate a large database and help identify relevant prognostic factors that can be incorporated into the staging system in future revisions.
Asunto(s)
Colesteatoma del Oído Medio , Otolaringología , Procedimientos Quirúrgicos Otológicos , Colesteatoma del Oído Medio/clasificación , Colesteatoma del Oído Medio/diagnóstico , Colesteatoma del Oído Medio/cirugía , Congresos como Asunto , Consenso , Progresión de la Enfermedad , Europa (Continente) , Medicina Basada en la Evidencia , Humanos , Procedimientos Quirúrgicos Otológicos/métodos , Pautas de la Práctica en Medicina , Sociedades MédicasRESUMEN
OBJECTIVE: Vertigo in childhood is a complaint consisting of a wide spectrum of diagnoses. The aim of this study was to evaluate pediatric patients with vertigo with normal eardrum and middle ear findings and discuss the differential diagnoses. METHODS: Patient records of 50 children under 18 years of age with vertigo as the chief complaint, examined at the Baskent University, Research and Application Centers at Konya and Adana otorhinolaryngology clinics between May 2003 and October 2005 were retrospectively reviewed. The questionnaires, laboratory tests including blood samples, audiological and vestibular tests, and final diagnoses were analyzed. Patients with perforated eardrums, otitis media with effusion, and acute upper respiratory tract infections were not included in the study. RESULTS: The study group consisted of 50 patients (33 females, 66%; 17 males, 34%), between 4 and 17 years of age (mean age, 11.5+/-3.9 years). Severe sensorineural hearing loss was present in one patient unilaterally (2%) and one patient bilaterally (2%). Bilateral low-frequency sensorineural hearing loss was present in one patient (2%). Electronystagmography revealed central vestibular abnormalities in three patients (6%). Canal paresis was established in six patients (12%). The Dix-Hallpike test was positive in six patients (12%). The most frequent cause of vertigo was migraine, occurring in 34% of patients (n=17). Other less-frequent etiologies of vertigo were benign paroxysmal vertigo (n=6; 12%), benign paroxysmal positional vertigo (n=6; 12%), psychogenic vertigo (n=5; 10%), epilepsy (n=3; 6%), metabolic disorders (n=3; 6%), vestibular neuritis (n=2; 4%), Meniere's disease (n=1; 2%), perilymphatic fistula (n=1; 2%), amblyopia (n=1; 2%), and unclassifiable (n=5; 10%). CONCLUSIONS: Migraine was found to be the most frequent presenting diagnosis in childhood vertigo, although several peripheral vestibular disorders also were diagnosed. Evaluation of vertigo in childhood should begin with a thorough neuro-otologic evaluation and include other relevant multidisciplinary team members as needed to avoid unnecessary effort and cost.
Asunto(s)
Vértigo/diagnóstico , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Estudios RetrospectivosRESUMEN
OBJECTIVES: We investigated the effect of intratympanic gentamicin and dexamethasone treatments on the control of vertigo and hearing loss in patients with Meniere's disease. PATIENTS AND METHODS: Forty-five patients with a diagnosis of Meniere's disease according to the 1995 criteria of American Academy of Otorhinolaryngology Head and Neck Surgery were assigned to receive intratympanic gentamicin (40 mg/ml, 0.7 ml; n=24; 11 males, 13 females; mean age 46 years) or dexamethasone (4 mg/ml, 0.7 ml; n=21; 8 males, 13 females; mean age 50.4 years). The results were evaluated with respect to changes in vertigo and hearing symptoms. RESULTS: In the gentamicin group, vertigo symptoms were controlled in 22 patients (92%), deterioration in hearing was seen in only two patients (8%). In the dexamethasone group, nine patients had complete follow-up. Of these, vertigo control was achieved in six patients (67%), none had worsened hearing, and one patient (5%) had improved hearing. When improvement in hearing was defined as at least a 5 dB change, then five patients (24%) benefited from treatment. CONCLUSION: Intratympanic treatment modalities in Meniere's disease are easy to perform, cheap, and effective. They are expected to have a more extensive use with higher success rates in the future.
Asunto(s)
Antibacterianos/administración & dosificación , Antiinflamatorios/administración & dosificación , Dexametasona/administración & dosificación , Gentamicinas/administración & dosificación , Enfermedad de Meniere/tratamiento farmacológico , Membrana Timpánica , Quimioterapia Combinada , Femenino , Pérdida Auditiva Sensorineural/etiología , Pérdida Auditiva Sensorineural/prevención & control , Humanos , Inyecciones Intralesiones , Masculino , Enfermedad de Meniere/complicaciones , Persona de Mediana Edad , Resultado del Tratamiento , Vértigo/etiología , Vértigo/prevención & controlRESUMEN
Epithelial cysts are benign epithelium-lined lesions that contain fluid or semisolid material. This type of cyst is rare in the oral cavity. Most epithelial cysts in this location are situated in the anterior floor of the mouth; the soft palate is seldom affected. Oral examination in a 6-year-old boy revealed a cyst in the soft palate. The lesion was excised under general anesthesia, and histopathological examination identified it as an epithelial cyst. The report discusses this rare location for an epithelial cyst and reviews the pertinent literature.
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Quistes/patología , Enfermedades de la Boca/patología , Paladar Blando/patología , Niño , Tos/etiología , Quistes/complicaciones , Quistes/cirugía , Humanos , Masculino , Enfermedades de la Boca/complicaciones , Enfermedades de la Boca/cirugía , Paladar Blando/cirugía , Resultado del TratamientoRESUMEN
Fibrous dysplasia is an uncommon benign bone disorder of unknown etiology in which normal medullary bone is replaced by fibrotic and osseous tissue. Solitary involvement of the sphenoid sinus is unusual. Here, we present the case of a 28-year-old man complaining of occipital and vertical headache. Imaging modalities demonstrated an expansile lesion filling the entire sphenoid sinus. Biopsy specimen was obtained by endoscopic sphenoidotomy. Diagnosis of fibrous dysplasia was made by imaging results and pathologic examination.
Asunto(s)
Displasia Fibrosa Monostótica/diagnóstico , Hueso Esfenoides/patología , Seno Esfenoidal/patología , Adulto , Biopsia , Diagnóstico Diferencial , Displasia Fibrosa Monostótica/patología , Humanos , Imagen por Resonancia Magnética , Masculino , Tomografía Computarizada por Rayos XAsunto(s)
Infecciones por Coronavirus , Pandemias , Neumonía Viral , Edición/tendencias , Betacoronavirus , COVID-19 , Humanos , SARS-CoV-2RESUMEN
Development of a consensus on the definitions and classification of cholesteatoma is essential for scientific community to exchange information on clinical studies and compare their outcomes. The aim of the study is to reach a consensus among members of the European Academy of Otology and Neurotology (EAONO) regarding the definitions and classification related to cholesteatoma. A set of statements was developed by the authors utilizing the literature on the definition and classification of cholesteatoma. A questionnaire was sent to the members of the EAONO, inviting them to state if they are in agreement with each of the statements and if not, then to provide comments or suggestions for revision. Responses were evaluated and modified using online questionnaire and survey software based on the Delphi technique, a cyclical process of gathering information, summarizing, and re-submitting the revised statements to the same target population until a consensus is reached. Target agreement among the responders was set at a minimum of 80%, and the cycle of revision and re-submission of the statements were repeated until a consensus was reached on a majority of the statements. A steering group has been established to evaluate the results of the survey and worked via the process of cognitive debriefing. Out of 364 EAONO members, 123 responded to the first consensus cycle, 77 to the second cycle, and 53 to the third cycle. After three cycles, all statements concerning cholesteatoma definitions reached the target of 80% consensus. However, a consensus on the classification of cholesteatoma could not be achieved. The steering group excluded four statements of cholesteatoma definition and established a consensus on cholesteatoma classification. A consensus on cholesteatoma definitions was reached among the members of the EAONO. The final revision on consensus statements for cholesteatoma definition and classification has been made via the process of cognitive debriefing of the steering group.
Asunto(s)
Colesteatoma/clasificación , Consenso , Técnica Delphi , Humanos , Encuestas y CuestionariosRESUMEN
We used pipe models to investigate the effects of paranasal sinus ostium size and paranasal sinus volume on the area-distance curves derived by acoustic rhinometry (AR). Each model had a Helmholtz resonator or a short neck as a side branch that simulated the paranasal sinus and sinus ostium. The AR-derived cross-sectional areas posterior to the ostium were significantly overestimated. Sinus volume affected the AR measurements only when the sinus was connected via a relatively large ostium. The experimental area-distance curve posterior to the side branch showed pronounced oscillations in association with low-frequency acoustic resonances in this distal part of the pipe. The experimental results are discussed in terms of theoretically calculated "sound-power reflection coefficients" for the pipe models used. The results indicate that the effects of paranasal sinuses and low-frequency acoustic resonances in the posterior part of the nasal cavity are not accounted for in the current AR algorithms. AR does not provide reliable information about sinus ostium size, sinus volume, or cross-sectional area in the distal parts of nasal cavity.
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Senos Paranasales/anatomía & histología , Rinometría Acústica , Humanos , Modelos AnatómicosRESUMEN
The authors report an extremely rare case of complete fistula of the second branchial cleft, with an external opening in the skin and an internal opening in the oropharyngeal mucosa. A 13-year-old girl presented with the complaint of intermittent drainage from the right side of her neck, a problem that had existed since birth. Fistulography revealed a complete fistula of the second branchial cleft. Before surgical excision, a 4-F catheter and a 0.018-in guide-wire were inserted into the external opening of the fistula and passed through to the tonsillar region under fluoroscopic guidance. The infrahyoid segment and parapharyngeal segment of the fistula were then excised through first- and second-step neck incisions, respectively. In this case, tonsillectomy was not necessary. Pathological examination of the wall of the fistula revealed lymphoid tissue containing lymphoid follicles. This report describes a technique in which complete excision of a fistula of the second branchial arch is facilitated by placing a catheter in the tract.
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Región Branquial/cirugía , Fístula Cutánea/cirugía , Orofaringe , Fístula del Sistema Respiratorio/cirugía , Adolescente , Región Branquial/patología , Cateterismo/instrumentación , Fístula Cutánea/diagnóstico , Fístula Cutánea/patología , Femenino , Humanos , Tejido Linfoide/patología , Orofaringe/patología , Orofaringe/cirugía , Fístula del Sistema Respiratorio/diagnóstico , Fístula del Sistema Respiratorio/patologíaRESUMEN
Epidermoid carcinoma (also known as squamous cell carcinoma) of the parotid gland is more prevalent among the elderly, as are other head and neck tumors. In most cases it is observed either as a nodal metastasis of a primary tumor that drains into the parotid area or as a direct extension of a tumor that has originated in the upper dermis. Primary epidermoid carcinomas arising directly from the parotid gland are extremely rare. Similarly, secondary invasion of the orbital region by a neighboring tumor is more common than primary epidermoid carcinoma of the orbit, which is also rare. In this article, we discuss the diagnosis and treatment of a rare case of epidermoid carcinoma simultaneously invading the parotid gland and the orbit.
Asunto(s)
Carcinoma de Células Escamosas , Neoplasias Orbitales , Neoplasias de la Parótida , Anciano de 80 o más Años , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/terapia , Resultado Fatal , Femenino , Humanos , Neoplasias Orbitales/diagnóstico , Neoplasias Orbitales/terapia , Neoplasias de la Parótida/diagnóstico , Neoplasias de la Parótida/terapiaRESUMEN
OBJECTIVE: To study the effects of various densities of middle ear fluids on acoustic immittance and elucidate the characteristics of this study that might be beneficial for clinical use in otitis media with effusion. STUDY DESIGN: Experimental, in vivo model. MATERIALS AND METHODS: The study was performed on 12 ears of six white Vienna rabbits. Rabbits were placed in six positions: normal resting position (group 1); after drilling a hole into the tympanic bulla (group 2); filling the bulla with distilled water (group 3; density = 1000 g/cm(3)); filling the bulla with 8.4% bicarbonate solution (group 4; density = 1005 g/cm(3)); filling the bulla with Tonimer gel (group 5; density = 1035 g/cm(3)); and filling the bulla with glycerine (group 6; density > 1050 g/cm(3)). Acoustic immittance measurements were then made in vivo. During each measurement, volume, compliance, pressure, and gradient values were recorded. Analysis of variance, Student t-test, and Pearson correlation coefficient and multiple regression analyses were used for statistical evaluations of the data. RESULTS: Volume, compliance, and pressure values were obtained in all of the six measurements. A significant difference in volume was found between groups 1 and 2 (p < .001) and between the other four groups in this study (p < .001). With regard to compliance, group 2 was significantly different from groups 3, 4, 5, and 6 (p < .001). With regard to pressure, there was no intergroup (1 and 2) difference (p = .639); however, a significant difference (p < .001) was found between groups 1 and 2 and the other four groups. A significant difference was found between groups 3 and 6 (p = .006). A gradient value was obtained in all of the six measurements only for groups 1 and 2. In group 2, a significant rise in gradient was observed (p = .001). CONCLUSION: Generally, volume, compliance, and pressure values declined significantly in rabbits in which the bulla had been filled with fluid when compared with rabbits with empty bullae. Drilling a hole into the bulla increased volumetric values under normal conditions but had no effect on compliance and pressure values. The significant difference between groups 3 and 6 regarding pressure demonstrates that the density of fluid in the middle ear plays a role in pressure values when measured with tympanometry. We conclude that the correlation between density and pressure values of middle ear fluids may be useful in the clinical decision-making process when treating disorders such as otitis media.