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1.
Am J Physiol Lung Cell Mol Physiol ; 327(4): L464-L472, 2024 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-39104316

RESUMEN

Chronic obstructive pulmonary disease (COPD) is regarded as an accelerated-age disease in which chronic inflammation, maladaptive immune responses, and senescence cell burden coexist. Accordingly, cellular senescence has emerged as a potential mechanism involved in COPD pathophysiology. In this study, 25 stable patients with COPD underwent a daily physical activity promotion program for 6 mo. We reported that increase of physical activity was related to a reduction of the senescent cell burden in circulating lymphocytes of patients with COPD. Senescent T-lymphocyte population, characterized by absence of surface expression of CD28, was reduced after physical activity intervention, and the reduction was associated to the increase of physical activity level. In addition, the mRNA expression of cyclin-dependent kinase inhibitors, a hallmark of cell senescence, was reduced and, in accordance, the proliferative capacity of lymphocytes was improved postintervention. Moreover, we observed an increase in functionality in T cells from patients after intervention, including improved markers of activation, enhanced cytotoxicity, and altered cytokine secretions in response to viral challenge. Lastly, physical activity intervention reduced the potential of lymphocytes' secretome to induce senescence in human primary fibroblasts. In conclusion, our study provides, for the first time, evidence of the potential of physical activity intervention in patients with COPD to reduce the senescent burden in circulating immune cells.NEW & NOTEWORTHY For the first time, we identified in patients with COPD a relation between physical activity intervention with respiratory function improvement and cellular senescence burden in lymphocytes that improved the T cell functionality and proliferative capacity of patients. In addition, our experiments highlight the possible impact of T-cell senescence in other cell types which could be related to some of the clinical lung complications observed in COPD.


Asunto(s)
Senescencia Celular , Ejercicio Físico , Enfermedad Pulmonar Obstructiva Crónica , Humanos , Enfermedad Pulmonar Obstructiva Crónica/inmunología , Enfermedad Pulmonar Obstructiva Crónica/patología , Enfermedad Pulmonar Obstructiva Crónica/metabolismo , Masculino , Femenino , Ejercicio Físico/fisiología , Anciano , Persona de Mediana Edad , Linfocitos/inmunología , Linfocitos/metabolismo , Linfocitos T/inmunología , Linfocitos T/metabolismo , Fibroblastos/metabolismo , Fibroblastos/patología , Proliferación Celular , Citocinas/metabolismo , Activación de Linfocitos
2.
Sensors (Basel) ; 23(17)2023 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-37688015

RESUMEN

In recent years, the application of artificial intelligence (AI) in the automotive industry has led to the development of intelligent systems focused on road safety, aiming to improve protection for drivers and pedestrians worldwide to reduce the number of accidents yearly. One of the most critical functions of these systems is pedestrian detection, as it is crucial for the safety of everyone involved in road traffic. However, pedestrian detection goes beyond the front of the vehicle; it is also essential to consider the vehicle's rear since pedestrian collisions occur when the car is in reverse drive. To contribute to the solution of this problem, this research proposes a model based on convolutional neural networks (CNN) using a proposed one-dimensional architecture and the Inception V3 architecture to fuse the information from the backup camera and the distance measured by the ultrasonic sensors, to detect pedestrians when the vehicle is reversing. In addition, specific data collection was performed to build a database for the research. The proposed model showed outstanding results with 99.85% accuracy and 99.86% correct classification performance, demonstrating that it is possible to achieve the goal of pedestrian detection using CNN by fusing two types of data.

3.
Sensors (Basel) ; 23(2)2023 Jan 10.
Artículo en Inglés | MEDLINE | ID: mdl-36679580

RESUMEN

Driver identification refers to the process whose primary purpose is identifying the person behind the steering wheel using collected information about the driver him/herself. The constant monitoring of drivers through sensors generates great benefits in advanced driver assistance systems (ADAS), to learn more about the behavior of road users. Currently, there are many research works that address the subject in search of creating intelligent models that help to identify vehicle users in an efficient and objective way. However, the different methodologies proposed to create these models are based on data generated from sensors that include different vehicle brands on routes established in real environments, which, although they provide very important information for different purposes, in the case of driver identification, there may be a certain degree of bias due to the different situations in which the route environment may change. The proposed method seeks to intelligently and objectively select the most outstanding statistical features from motor activity generated in the main elements of the vehicle with genetic algorithms for driver identification, this process being newer than those established by the state-of-the-art. The results obtained from the proposal were an accuracy of 90.74% to identify two drivers and 62% for four, using a Random Forest Classifier (RFC). With this, it can be concluded that a comprehensive selection of features can greatly optimize the identification of drivers.


Asunto(s)
Conducción de Automóvil , Humanos , Masculino , Accidentes de Tránsito , Bosques Aleatorios , Aprendizaje , Actividad Motora
4.
Rev Invest Clin ; 74(6): 314-327, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36546894

RESUMEN

Background: The coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus and is responsible for nearly 6 million deaths worldwide in the past 2 years. Machine learning (ML) models could help physicians in identifying high-risk individuals. Objectives: To study the use of ML models for COVID-19 prediction outcomes using clinical data and a combination of clinical and metabolic data, measured in a metabolomics facility from a public university. Methods: A total of 154 patients were included in the study. "Basic profile" was considered with clinical and demographic variables (33 variables), whereas in the "extended profile," metabolomic and immunological variables were also considered (156 characteristics). A selection of features was carried out for each of the profiles with a genetic algorithm (GA) and random forest models were trained and tested to predict each of the stages of COVID-19. Results: The model based on extended profile was more useful in early stages of the disease. Models based on clinical data were preferred for predicting severe and critical illness and death. ML detected trimethylamine N-oxide, lipid mediators, and neutrophil/lymphocyte ratio as important variables. Conclusions: ML and GAs provided adequate models to predict COVID-19 outcomes in patients with different severity grades.


Asunto(s)
COVID-19 , SARS-CoV-2 , Humanos , COVID-19/diagnóstico , Algoritmos , Pronóstico , Aprendizaje Automático
5.
Sensors (Basel) ; 21(22)2021 Nov 21.
Artículo en Inglés | MEDLINE | ID: mdl-34833826

RESUMEN

Worldwide, motor vehicle accidents are one of the leading causes of death, with alcohol-related accidents playing a significant role, particularly in child death. Aiming to aid in the prevention of this type of accidents, a novel non-invasive method capable of detecting the presence of alcohol inside a motor vehicle is presented. The proposed methodology uses a series of low-cost alcohol MQ3 sensors located inside the vehicle, whose signals are stored, standardized, time-adjusted, and transformed into 5 s window samples. Statistical features are extracted from each sample and a feature selection strategy is carried out using a genetic algorithm, and a forward selection and backwards elimination methodology. The four features derived from this process were used to construct an SVM classification model that detects presence of alcohol. The experiments yielded 7200 samples, 80% of which were used to train the model. The rest were used to evaluate the performance of the model, which obtained an area under the ROC curve of 0.98 and a sensitivity of 0.979. These results suggest that the proposed methodology can be used to detect the presence of alcohol and enforce prevention actions.


Asunto(s)
Conducción de Automóvil , Conducir bajo la Influencia , Accidentes de Tránsito/prevención & control , Algoritmos , Niño , Humanos , Vehículos a Motor
6.
Sensors (Basel) ; 18(2)2018 Feb 03.
Artículo en Inglés | MEDLINE | ID: mdl-29401637

RESUMEN

Among the current challenges of the Smart City, traffic management and maintenance are of utmost importance. Road surface monitoring is currently performed by humans, but the road surface condition is one of the main indicators of road quality, and it may drastically affect fuel consumption and the safety of both drivers and pedestrians. Abnormalities in the road, such as manholes and potholes, can cause accidents when not identified by the drivers. Furthermore, human-induced abnormalities, such as speed bumps, could also cause accidents. In addition, while said obstacles ought to be signalized according to specific road regulation, they are not always correctly labeled. Therefore, we developed a novel method for the detection of road abnormalities (i.e., speed bumps). This method makes use of a gyro, an accelerometer, and a GPS sensor mounted in a car. After having the vehicle cruise through several streets, data is retrieved from the sensors. Then, using a cross-validation strategy, a genetic algorithm is used to find a logistic model that accurately detects road abnormalities. The proposed model had an accuracy of 0.9714 in a blind evaluation, with a false positive rate smaller than 0.018, and an area under the receiver operating characteristic curve of 0.9784. This methodology has the potential to detect speed bumps in quasi real-time conditions, and can be used to construct a real-time surface monitoring system.

7.
Sensors (Basel) ; 17(11)2017 Nov 21.
Artículo en Inglés | MEDLINE | ID: mdl-29160799

RESUMEN

Human Activity Recognition (HAR) is one of the main subjects of study in the areas of computer vision and machine learning due to the great benefits that can be achieved. Examples of the study areas are: health prevention, security and surveillance, automotive research, and many others. The proposed approaches are carried out using machine learning techniques and present good results. However, it is difficult to observe how the descriptors of human activities are grouped. In order to obtain a better understanding of the the behavior of descriptors, it is important to improve the abilities to recognize the human activities. This paper proposes a novel approach for the HAR based on acoustic data and similarity networks. In this approach, we were able to characterize the sound of the activities and identify those activities looking for similarity in the sound pattern. We evaluated the similarity of the sounds considering mainly two features: the sound location and the materials that were used. As a result, the materials are a good reference classifying the human activities compared with the location.


Asunto(s)
Actividades Humanas , Acústica , Humanos , Reconocimiento de Normas Patrones Automatizadas , Procesamiento de Señales Asistido por Computador , Sonido
8.
Traffic Inj Prev ; 25(6): 842-851, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38717829

RESUMEN

OBJECTIVE: One of the main causes of death worldwide among young people are car crashes, and most of these fatalities occur to children who are seated in the front passenger seat and who, at the time of an accident, receive a direct impact from the airbags, which is lethal for children under 13 years of age. The present study seeks to raise awareness of this risk by interior monitoring with a child face detection system that serves to alert the driver that the child should not be sitting in the front passenger seat. METHODS: The system incorporates processing of data collected, elements of deep learning such as transfer learning, fine-tunning and facial detection to identify the presence of children in a robust way, which was achieved by training with a dataset generated from scratch for this specific purpose. The MobileNetV2 architecture was used based on the good performance shown when compared with the Inception architecture for this task; and its low computational cost, which facilitates implementing the final model on a Raspberry Pi 4B. RESULTS: The resulting image dataset consisted of 102 empty seats, 71 children (0-13 years), and 96 adults (14-75 years). From the data augmentation, there were 2,496 images for adults and 2,310 for children. The classification of faces without sliding window gave a result of 98% accuracy and 100% precision. Finally, using the proposed methodology, it was possible to detect children in the front passenger seat in real time, with a delay of 1 s per decision and sliding window criterion, reaching an accuracy of 100%. CONCLUSIONS: Although our 100% accuracy in an experimental environment is somewhat idealized in that the sensor was not blocked by direct sunlight, nor was it partially or completely covered by dirt or other debris common in vehicles transporting children. The present study showed that is possible the implementation of a robust noninvasive classification system made on Raspberry Pi 4 Model B in any automobile for the detection of a child in the front seat through deep learning methods such as Deep CNN.


Asunto(s)
Accidentes de Tránsito , Aprendizaje Profundo , Humanos , Niño , Preescolar , Adolescente , Lactante , Accidentes de Tránsito/prevención & control , Adulto , Adulto Joven , Persona de Mediana Edad , Anciano , Recién Nacido , Femenino , Masculino , Sistemas de Retención Infantil/estadística & datos numéricos , Reconocimiento Facial Automatizado , Cara
9.
Diagnostics (Basel) ; 14(15)2024 Jul 27.
Artículo en Inglés | MEDLINE | ID: mdl-39125499

RESUMEN

Type 2 diabetes mellitus (T2DM) is one of the most common metabolic diseases in the world and poses a significant public health challenge. Early detection and management of this metabolic disorder is crucial to prevent complications and improve outcomes. This paper aims to find core differences in male and female markers to detect T2DM by their clinic and anthropometric features, seeking out ranges in potential biomarkers identified to provide useful information as a pre-diagnostic tool whie excluding glucose-related biomarkers using machine learning (ML) models. We used a dataset containing clinical and anthropometric variables from patients diagnosed with T2DM and patients without TD2M as control. We applied feature selection with three different techniques to identify relevant biomarker models: an improved recursive feature elimination (RFE) evaluating each set from all the features to one feature with the Akaike information criterion (AIC) to find optimal outputs; Least Absolute Shrinkage and Selection Operator (LASSO) with glmnet; and Genetic Algorithms (GA) with GALGO and forward selection (FS) applied to GALGO output. We then used these for comparison with the AIC to measure the performance of each technique and collect the optimal set of global features. Then, an implementation and comparison of five different ML models was carried out to identify the most accurate and interpretable one, considering the following models: logistic regression (LR), artificial neural network (ANN), support vector machine (SVM), k-nearest neighbors (KNN), and nearest centroid (Nearcent). The models were then combined in an ensemble to provide a more robust approximation. The results showed that potential biomarkers such as systolic blood pressure (SBP) and triglycerides are together significantly associated with T2DM. This approach also identified triglycerides, cholesterol, and diastolic blood pressure as biomarkers with differences between male and female actors that have not been previously reported in the literature. The most accurate ML model was selection with RFE and random forest (RF) as the estimator improved with the AIC, which achieved an accuracy of 0.8820. In conclusion, this study demonstrates the potential of ML models in identifying potential biomarkers for early detection of T2DM, excluding glucose-related biomarkers as well as differences between male and female anthropometric and clinic profiles. These findings may help to improve early detection and management of the T2DM by accounting for differences between male and female subjects in terms of anthropometric and clinic profiles, potentially reducing healthcare costs and improving personalized patient attention. Further research is needed to validate these potential biomarkers ranges in other populations and clinical settings.

10.
J Eval Clin Pract ; 29(1): 117-125, 2023 02.
Artículo en Inglés | MEDLINE | ID: mdl-35856486

RESUMEN

RATIONALE, AIMS AND OBJECTIVES: The healthcare system and professionals working in the sector have experienced a high caseload during the coronavirus disease 2019 (COVID-19) pandemic. This has increased the potential for morally harmful events that violate professionals' moral codes and values. The aim of this study was to understand and explore experiences of new moral challenges emerging among physicians and nurses caring for individuals during the COVID-19 pandemic. METHOD: The consolidated criteria for reporting qualitative research (COREQ) checklist was used in this qualitative study based on Gadamer's phenomenology. Participants were selected using a convenience sampling method. Thirteen medicine and nursing graduates were interviewed in depth. The participants all worked on the frontline at the start of the COVID-19 pandemic. Data were gathered in two basic healthcare districts in Spain, encompassing both primary care and hospital care. RESULTS: Four main themes emerged from the data analysis: (1) Betrayal of moral and ethical values as a key source of suffering; (2) Ethical and moral sense of failure accompanying loss of meaning; (3) Lack of confidence in performance; (4) Self-demand and self-punishment as personal condemnation among healthcare workers. CONCLUSIONS: Health institutions must implement interventions for health professionals to help mitigate the consequences of experiencing complex ethical scenarios during the pandemic. In addition, they should promote training in moral and ethical deliberation and prepare them to make decisions of great ethical significance.


Asunto(s)
COVID-19 , Enfermeras y Enfermeros , Médicos , Humanos , COVID-19/epidemiología , Pandemias , Investigación Cualitativa
11.
Diseases ; 11(4)2023 Sep 30.
Artículo en Inglés | MEDLINE | ID: mdl-37873778

RESUMEN

The escalating prevalence of Type 2 Diabetes (T2D) represents a substantial burden on global healthcare systems, especially in regions such as Mexico. Existing diagnostic techniques, although effective, often require invasive procedures and labor-intensive efforts. The promise of artificial intelligence and data science for streamlining and enhancing T2D diagnosis is well-recognized; however, these advancements are frequently constrained by the limited availability of comprehensive patient datasets. To mitigate this challenge, the present study investigated the efficacy of Generative Adversarial Networks (GANs) for augmenting existing T2D patient data, with a focus on a Mexican cohort. The researchers utilized a dataset of 1019 Mexican nationals, divided into 499 non-diabetic controls and 520 diabetic cases. GANs were applied to create synthetic patient profiles, which were subsequently used to train a Random Forest (RF) classification model. The study's findings revealed a notable improvement in the model's diagnostic accuracy, validating the utility of GAN-based data augmentation in a clinical context. The results bear significant implications for enhancing the robustness and reliability of Machine Learning tools in T2D diagnosis and management, offering a pathway toward more timely and effective patient care.

12.
Diagnostics (Basel) ; 12(12)2022 Dec 08.
Artículo en Inglés | MEDLINE | ID: mdl-36553106

RESUMEN

Breast cancer is the most common cancer among women worldwide, after lung cancer. However, early detection of breast cancer can help to reduce death rates in breast cancer patients and also prevent cancer from spreading to other parts of the body. This work proposes a new method to design a bio-marker integrating Bayesian predictive models, pyRadiomics System and genetic algorithms to classify the benign and malignant lesions. The method allows one to evaluate two types of images: The radiologist-segmented lesion, and a novel automated breast cancer detection by the analysis of the whole breast. The results demonstrate only a difference of 12% of effectiveness for the cases of calcification between the radiologist generated segmentation and the automatic whole breast analysis, and a 25% of difference between the lesion and the breast for the cases of masses. In addition, our approach was compared against other proposed methods in the literature, providing an AUC = 0.86 for the analysis of images with lesions in breast calcification, and AUC = 0.96 for masses.

13.
Bioengineering (Basel) ; 9(9)2022 Sep 09.
Artículo en Inglés | MEDLINE | ID: mdl-36135004

RESUMEN

Depression is a common illness worldwide, affecting an estimated 3.8% of the population, including 5% of all adults, in particular, 5.7% of adults over 60 years of age. Unfortunately, at present, the ways to evaluate different mental disorders, like the Montgomery-Åsberg depression rating scale (MADRS) and observations, need a great effort, on part of specialists due to the lack of availability of patients to obtain the necessary information to know their conditions and to detect illness such as depression in an objective way. Based on data analysis and artificial intelligence techniques, like Convolutional Neural Network (CNN), it is possible to classify a person, from the mental status examination, into two classes. Moreover, it is beneficial to observe how the data of these two classes are similar in different time intervals. In this study, a motor activity database was used, from which the readings of 55 subjects of study (32 healthy and 23 with some degree of depression) were recorded with a small wrist-worn accelerometer to detect the peak amplitude of movement acceleration and generate a transient voltage signal proportional to the rate of acceleration. Motor activity data were selected per patient in time-lapses of one day for seven days (one week) in one-minute intervals. The data were pre-processed to be given to a two-dimensional convolutional network (2D-CNN), where each record of motor activity per minute was represented as a pixel of an image. The proposed model is capable of detecting depression in real-time (if this is implemented in a mobile device such as a smartwatch) with low computational cost and accuracy of 76.72% In summary, the model shows promising abilities to detect possible cases of depression, providing a helpful resource to identify the condition and be able to take the appropriate follow-up for the patient.

14.
Healthcare (Basel) ; 10(8)2022 Jul 22.
Artículo en Inglés | MEDLINE | ID: mdl-35893185

RESUMEN

Type 2 diabetes mellitus (T2DM) represents one of the biggest health problems in Mexico, and it is extremely important to early detect this disease and its complications. For a noninvasive detection of T2DM, a machine learning (ML) approach that uses ensemble classification models with dichotomous output that is also fast and effective for early detection and prediction of T2D can be used. In this article, an ensemble technique by hard voting is designed and implemented using generalized linear regression (GLM), support vector machines (SVM) and artificial neural networks (ANN) for the classification of T2DM patients. In the materials and methods as a first step, the data is balanced, standardized, imputed and integrated into the three models to classify the patients in a dichotomous result. For the selection of features, an implementation of LASSO is developed, with a 10-fold cross-validation and for the final validation, the Area Under the Curve (AUC) is used. The results in LASSO showed 12 features, which are used in the implemented models to obtain the best possible scenario in the developed ensemble model. The algorithm with the best performance of the three is SVM, this model obtained an AUC of 92% ± 3%. The ensemble model built with GLM, SVM and ANN obtained an AUC of 90% ± 3%.

15.
Healthcare (Basel) ; 10(7)2022 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-35885784

RESUMEN

Major depressive disorder (MDD) is the most recurrent mental illness globally, affecting approximately 5% of adults. Furthermore, according to the National Institute of Mental Health (NIMH) of the U.S., calculating an actual schizophrenia prevalence rate is challenging because of this illness's underdiagnosis. Still, most current global metrics hover between 0.33% and 0.75%. Machine-learning scientists use data from diverse sources to analyze, classify, or predict to improve the psychiatric attention, diagnosis, and treatment of MDD, schizophrenia, and other psychiatric conditions. Motor activity data are gaining popularity in mental illness diagnosis assistance because they are a cost-effective and noninvasive method. In the knowledge discovery in databases (KDD) framework, a model to classify depressive and schizophrenic patients from healthy controls is constructed using accelerometer data. Taking advantage of the multiple sleep disorders caused by mental disorders, the main objective is to increase the model's accuracy by employing only data from night-time activity. To compare the classification between the stages of the day and improve the accuracy of the classification, the total activity signal was cut into hourly time lapses and then grouped into subdatasets depending on the phases of the day: morning (06:00-11:59), afternoon (12:00-17:59), evening (18:00-23:59), and night (00:00-05:59). Random forest classifier (RFC) is the algorithm proposed for multiclass classification, and it uses accuracy, recall, precision, the Matthews correlation coefficient, and F1 score to measure its efficiency. The best model was night-featured data and RFC, with 98% accuracy for the classification of three classes. The effectiveness of this experiment leads to less monitoring time for patients, reducing stress and anxiety, producing more efficient models, using wearables, and increasing the amount of data.

16.
Healthcare (Basel) ; 10(7)2022 Jul 14.
Artículo en Inglés | MEDLINE | ID: mdl-35885829

RESUMEN

Sudden infant death syndrome (SIDS) represents the leading cause of death in under one year of age in developing countries. Even in our century, its etiology is not clear, and there is no biomarker that is discriminative enough to predict the risk of suffering from it. Therefore, in this work, taking a public dataset on the lipidomic profile of babies who died from this syndrome compared to a control group, a univariate analysis was performed using the Mann-Whitney U test, with the aim of identifying the characteristics that enable discriminating between both groups. Those characteristics with a p-value less than or equal to 0.05 were taken; once these characteristics were obtained, classification models were implemented (random forests (RF), logistic regression (LR), support vector machine (SVM) and naive Bayes (NB)). We used seventy percent of the data for model training, subjecting it to a cross-validation (k = 5) and later submitting to validation in a blind test with 30% of the remaining data, which allows simulating the scenario in real life-that is, with an unknown population for the model. The model with the best performance was RF, since in the blind test, it obtained an AUC of 0.9, specificity of 1, and sensitivity of 0.8. The proposed model provides the basis for the construction of a SIDS risk prediction computer tool, which will contribute to prevention, and proposes lines of research to deal with this pathology.

17.
Healthcare (Basel) ; 9(4)2021 Apr 06.
Artículo en Inglés | MEDLINE | ID: mdl-33917300

RESUMEN

Diabetes incidence has been a problem, because according with the World Health Organization and the International Diabetes Federation, the number of people with this disease is increasing very fast all over the world. Diabetic treatment is important to prevent the development of several complications, also lipid profile monitoring is important. For that reason the aim of this work is the implementation of machine learning algorithms that are able to classify cases, that corresponds to patients diagnosed with diabetes that have diabetes treatment, and controls that refers to subjects who do not have diabetes treatment but some of them have diabetes, bases on lipids profile levels. Logistic regression, K-nearest neighbor, decision trees and random forest were implemented, all of them were evaluated with accuracy, sensitivity, specificity and AUC-ROC curve metrics. Artificial neural network obtain an acurracy of 0.685 and an AUC value of 0.750, logistic regression achieve an accuracy of 0.729 and an AUC value of 0.795, K-nearest neighbor gets an accuracy of 0.669 and an AUC value of 0.709, on the other hand, decision tree reached an accuracy pg 0.691 and a AUC value of 0.683, finally random forest achieve an accuracy of 0.704 and an AUC curve of 0.776. The performance of all models was statistically significant, but the best performance model for this problem corresponds to logistic regression.

18.
Healthcare (Basel) ; 9(8)2021 Jul 31.
Artículo en Inglés | MEDLINE | ID: mdl-34442108

RESUMEN

Alzheimer's disease (AD) is a neurodegenerative disease that mainly affects older adults. Currently, AD is associated with certain hypometabolic biomarkers, beta-amyloid peptides, hyperphosphorylated tau protein, and changes in brain morphology. Accurate diagnosis of AD, as well as mild cognitive impairment (MCI) (prodromal stage of AD), is essential for early care of the disease. As a result, machine learning techniques have been used in recent years for the diagnosis of AD. In this research, we propose a novel methodology to generate a multivariate model that combines different types of features for the detection of AD. In order to obtain a robust biomarker, ADNI baseline data, clinical and neuropsychological assessments (1024 features) of 106 patients were used. The data were normalized, and a genetic algorithm was implemented for the selection of the most significant features. Subsequently, for the development and validation of the multivariate classification model, a support vector machine model was created, and a five-fold cross-validation with an AUC of 87.63% was used to measure model performance. Lastly, an independent blind test of our final model, using 20 patients not considered during the model construction, yielded an AUC of 100%.

19.
Polymers (Basel) ; 13(17)2021 Aug 25.
Artículo en Inglés | MEDLINE | ID: mdl-34502886

RESUMEN

In this work, we report the synthesis of copper nanoparticles (Cu NPs), employing the chemical reduction method in an aqueous medium. We used copper sulfate pentahydrate (CuSO4·5H2O) as a metallic precursor; polyethylenimine (PEI), allylamine (AAM), and 4-aminobutyric acid (AABT) as stabilizing agents; and hydrated hydrazine as a reducing agent. The characterization of the obtained nanoparticles consisted of X-ray, TEM, FTIR, and TGA analyses. Through these techniques, it was possible to detect the presence of the used stabilizing agents on the surface of the NPs. Finally, a zeta potential analysis was performed to differentiate the stability of the nanoparticles with a different type of stabilizing agent, from which it was determined that the most stable nanoparticles were the Cu NPs synthesized in the presence of the PEI/AAM mixture. The antimicrobial activity of Cu/PEI/AABT toward P. aeruginosa and S. aureus bacteria was high, inhibiting both bacteria with low contact times and copper concentrations of 50-200 ppm. The synthesis method allowed us to obtain Cu NPs free of oxides, stable to oxidation, and with high yields. The newly functionalized Cu NPs are potential candidates for antimicrobial applications.

20.
Healthcare (Basel) ; 9(7)2021 Jul 13.
Artículo en Inglés | MEDLINE | ID: mdl-34356262

RESUMEN

Children's healthcare is a relevant issue, especially the prevention of domestic accidents, since it has even been defined as a global health problem. Children's activity classification generally uses sensors embedded in children's clothing, which can lead to erroneous measurements for possible damage or mishandling. Having a non-invasive data source for a children's activity classification model provides reliability to the monitoring system where it is applied. This work proposes the use of environmental sound as a data source for the generation of children's activity classification models, implementing feature selection methods and classification techniques based on Bayesian networks, focused on the recognition of potentially triggering activities of domestic accidents, applicable in child monitoring systems. Two feature selection techniques were used: the Akaike criterion and genetic algorithms. Likewise, models were generated using three classifiers: naive Bayes, semi-naive Bayes and tree-augmented naive Bayes. The generated models, combining the methods of feature selection and the classifiers used, present accuracy of greater than 97% for most of them, with which we can conclude the efficiency of the proposal of the present work in the recognition of potentially detonating activities of domestic accidents.

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