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1.
Arch Toxicol ; 91(1): 97-107, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27425218

RESUMEN

The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document's topic that was subjected to voting by all experts as "yes" (agreement with the content and/or wording) or "no" (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.


Asunto(s)
Medicina Basada en la Evidencia , Osteoporosis/prevención & control , Deficiencia de Vitamina D/dietoterapia , Vitamina D/uso terapéutico , Animales , Trastorno del Espectro Autista/epidemiología , Trastorno del Espectro Autista/etiología , Trastorno del Espectro Autista/prevención & control , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/etiología , Enfermedades Cardiovasculares/prevención & control , Demencia/epidemiología , Demencia/etiología , Demencia/prevención & control , Diabetes Mellitus Tipo 1/epidemiología , Diabetes Mellitus Tipo 1/etiología , Diabetes Mellitus Tipo 1/prevención & control , Diabetes Mellitus Tipo 2/epidemiología , Diabetes Mellitus Tipo 2/etiología , Diabetes Mellitus Tipo 2/prevención & control , Femenino , Humanos , Infertilidad Femenina/epidemiología , Infertilidad Femenina/etiología , Infertilidad Femenina/prevención & control , Infertilidad Masculina/epidemiología , Infertilidad Masculina/etiología , Infertilidad Masculina/prevención & control , Masculino , Neoplasias/epidemiología , Neoplasias/etiología , Neoplasias/prevención & control , Osteoporosis/epidemiología , Osteoporosis/etiología , Guías de Práctica Clínica como Asunto , Riesgo , Deficiencia de Vitamina D/fisiopatología
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