Detalles de la búsqueda
1.
Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.
Chembiochem;
17(20): 1925-1930, 2016 10 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-27504718
2.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem J;
460(2): 211-22, 2014 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24593284
3.
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
J Med Chem;
64(1): 326-342, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33356244
4.
Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity.
J Pharmacol Exp Ther;
333(3): 707-16, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20228155
5.
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Bioorg Med Chem Lett;
20(5): 1543-7, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20137931
6.
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Bioorg Med Chem Lett;
19(16): 4882-4, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616942
7.
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
J Med Chem;
62(17): 7669-7683, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31415173
8.
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett;
10(1): 80-85, 2019 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655951
9.
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J Med Chem;
61(3): 1130-1152, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29298069
10.
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
J Med Chem;
60(7): 3094-3108, 2017 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28257199
11.
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
ACS Chem Biol;
10(4): 1094-8, 2015 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25571984
12.
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.
Mol Biosyst;
11(10): 2709-12, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25959423
13.
Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.
Bioorg Med Chem;
15(10): 3390-412, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17387018
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