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1.

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA).

Lim, Shuhui; Khoo, Regina; Peh, Khong Ming; Teo, Jinkai; Chang, Shih Chieh; Ng, Simon; Beilhartz, Greg L; Melnyk, Roman A; Johannes, Charles W; Brown, Christopher J; Lane, David P; Henry, Brian; Partridge, Anthony W.

Proc Natl Acad Sci U S A; 117(11): 5791-5800, 2020 03 17.

Artículo en Inglés | MEDLINE | ID: mdl-32123106

2.

Molecular descriptors suggest stapling as a strategy for optimizing membrane permeability of cyclic peptides.

Li, Jianguo; Kannan, Srinivasaraghavan; Aronica, Pietro; Brown, Christopher J; Partridge, Anthony W; Verma, Chandra S.

J Chem Phys; 156(6): 065101, 2022 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-35168356

3.

Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.

Desai, Tanvi J; Habulihaz, Bahanu; Cannon, Joe R; Chandramohan, Arun; Kaan, Hung Yi Kristal; Sadruddin, Ahmad; Yuen, Tsz Ying; Johannes, Charles; Thean, Dawn; Brown, Chris J; Lane, David P; Partridge, Anthony W; Evers, Raymond; Sawyer, Tomi K; Hochman, Jerome.

Pharm Res; 38(5): 843-850, 2021 May.

Artículo en Inglés | MEDLINE | ID: mdl-33723794

4.

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors.

Kannan, Srinivasaraghavan; Partridge, Anthony W; Lane, David P; Verma, Chandra S.

Int J Mol Sci; 20(23)2019 Nov 28.

Artículo en Inglés | MEDLINE | ID: mdl-31795143

5.

Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides.

Diller, David J; Swanson, Jon; Bayden, Alexander S; Brown, Chris J; Thean, Dawn; Lane, David P; Partridge, Anthony W; Sawyer, Tomi K; Audie, Joseph.

Molecules; 24(24)2019 Dec 14.

Artículo en Inglés | MEDLINE | ID: mdl-31847417

6.

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.

Partridge, Anthony W; Kaan, Hung Yi Kristal; Juang, Yu-Chi; Sadruddin, Ahmad; Lim, Shuhui; Brown, Christopher J; Ng, Simon; Thean, Dawn; Ferrer, Fernando; Johannes, Charles; Yuen, Tsz Ying; Kannan, Srinivasaraghavan; Aronica, Pietro; Tan, Yaw Sing; Pradhan, Mohan R; Verma, Chandra S; Hochman, Jerome; Chen, Shiying; Wan, Hui; Ha, Sookhee; Sherborne, Brad; Lane, David P; Sawyer, Tomi K.

Molecules; 24(12)2019 Jun 20.

Artículo en Inglés | MEDLINE | ID: mdl-31226791

7.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

Sawyer, Tomi K; Partridge, Anthony W; Kaan, Hung Yi Kristal; Juang, Yu-Chi; Lim, Shuhui; Johannes, Charles; Yuen, Tsz Ying; Verma, Chandra; Kannan, Srinivasaraghavan; Aronica, Pietro; Tan, Yaw Sing; Sherborne, Brad; Ha, Sookhee; Hochman, Jerome; Chen, Shiying; Surdi, Laura; Peier, Andrea; Sauvagnat, Berengere; Dandliker, Peter J; Brown, Christopher J; Ng, Simon; Ferrer, Fernando; Lane, David P.

Bioorg Med Chem; 26(10): 2807-2815, 2018 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-29598901

8.

Protein Polymerization as a Novel Targeted Protein Degradation Mechanism.

Berger, Raphaëlle; Partridge, Anthony W.

Biochemistry; 60(15): 1145-1147, 2021 04 20.

Artículo en Inglés | MEDLINE | ID: mdl-33759499

9.

Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.

Desai, Tanvi J; Habulihaz, Bahanu; Cannon, Joseph R; Chandramohan, Arun; Kaan, Hung Yi Kristal; Sadruddin, Ahmad; Yuen, Tsz Ying; Johannes, Charles; Thean, Dawn; Brown, Chris J; Lane, David P; Partridge, Anthony W; Evers, Raymond; Sawyer, Tomi K; Hochman, Jerome.

Pharm Res; 38(4): 735-736, 2021 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-33821425

10.

MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors.

Ingelshed, Katrine; Melssen, Marit M; Kannan, Pavitra; Chandramohan, Arun; Partridge, Anthony W; Jiang, Long; Wermeling, Fredrik; Lane, David P; Nestor, Marika; Spiegelberg, Diana.

iScience; 27(6): 109862, 2024 Jun 21.

Artículo en Inglés | MEDLINE | ID: mdl-38784022

11.

mRNAid, an open-source platform for therapeutic mRNA design and optimization strategies.

Vostrosablin, Nikita; Lim, Shuhui; Gopal, Pooja; Brazdilova, Kveta; Parajuli, Sushmita; Wei, Xiaona; Gromek, Anna; Prihoda, David; Spale, Martin; Muzdalo, Anja; Greig, Jamie; Yeo, Constance; Wardyn, Joanna; Mejzlik, Petr; Henry, Brian; Partridge, Anthony W; Bitton, Danny A.

NAR Genom Bioinform; 6(1): lqae028, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38482061

12.

Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.

Wirjanata, Grennady; Lin, Jianqing; Dziekan, Jerzy Michal; El Sahili, Abbas; Chung, Zara; Tjia, Seth; Binte Zulkifli, Nur Elyza; Boentoro, Josephine; Tham, Roy; Jia, Lai Si; Go, Ka Diam; Yu, Han; Partridge, Anthony; Olsen, David; Prabhu, Nayana; Sobota, Radoslaw M; Nordlund, Pär; Lescar, Julien; Bozdech, Zbynek.

Cell Chem Biol; 31(4): 743-759.e8, 2024 Apr 18.

Artículo en Inglés | MEDLINE | ID: mdl-38593807

13.

Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.

Chandramohan, Arun; Josien, Hubert; Yuen, Tsz Ying; Duggal, Ruchia; Spiegelberg, Diana; Yan, Lin; Juang, Yu-Chi Angela; Ge, Lan; Aronica, Pietro G; Kaan, Hung Yi Kristal; Lim, Yee Hwee; Peier, Andrea; Sherborne, Brad; Hochman, Jerome; Lin, Songnian; Biswas, Kaustav; Nestor, Marika; Verma, Chandra S; Lane, David P; Sawyer, Tomi K; Garbaccio, Robert; Henry, Brian; Kannan, Srinivasaraghavan; Brown, Christopher J; Johannes, Charles W; Partridge, Anthony W.

Nat Commun; 15(1): 489, 2024 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-38216578

14.

A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays.

Kasper, Stephen H; Otten, Stephanie; Squadroni, Brian; Orr-Terry, Cionna; Kuang, Yi; Mussallem, Lily; Ge, Lan; Yan, Lin; Kannan, Srinivasaraghavan; Verma, Chandra S; Brown, Christopher J; Johannes, Charles W; Lane, David P; Chandramohan, Arun; Partridge, Anthony W; Roberts, Lee R; Josien, Hubert; Therien, Alex G; Hett, Erik C; Howell, Bonnie J; Peier, Andrea; Ai, Xi; Cassaday, Jason.

Bioeng Transl Med; 8(5): e10542, 2023 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-37693049

15.

Integrin regulation.

Ginsberg, Mark H; Partridge, Anthony; Shattil, Sanford J.

Curr Opin Cell Biol; 17(5): 509-16, 2005 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-16099636

16.

Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology.

Garrigou, Michael; Sauvagnat, Bérengère; Duggal, Ruchia; Boo, Nicole; Gopal, Pooja; Johnston, Jennifer M; Partridge, Anthony; Sawyer, Tomi; Biswas, Kaustav; Boyer, Nicolas.

J Med Chem; 65(13): 8961-8974, 2022 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-35707970

17.

Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics.

Sun, Yue; Lau, Sze Yi; Lim, Zhi Wei; Chang, Shi Chieh; Ghadessy, Farid; Partridge, Anthony; Miserez, Ali.

Nat Chem; 14(3): 274-283, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35115657

18.

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death.

Chang, Shih Chieh; Gopal, Pooja; Lim, Shuhui; Wei, Xiaona; Chandramohan, Arun; Mangadu, Ruban; Smith, Jeffrey; Ng, Simon; Gindy, Marian; Phan, Uyen; Henry, Brian; Partridge, Anthony William.

Cell Chem Biol; 29(11): 1601-1615.e7, 2022 11 17.

Artículo en Inglés | MEDLINE | ID: mdl-36318925

19.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

Ng, Simon; Brueckner, Alexander C; Bahmanjah, Soheila; Deng, Qiaolin; Johnston, Jennifer M; Ge, Lan; Duggal, Ruchia; Habulihaz, Bahanu; Barlock, Benjamin; Ha, Sookhee; Sadruddin, Ahmad; Yeo, Constance; Strickland, Corey; Peier, Andrea; Henry, Brian; Sherer, Edward C; Partridge, Anthony W.

J Med Chem; 2022 Jul 19.

Artículo en Inglés | MEDLINE | ID: mdl-35853179

20.

STUB1 is an intracellular checkpoint for interferon gamma sensing.

Ng, Simon; Lim, Shuhui; Sim, Adrian Chong Nyi; Mangadu, Ruban; Lau, Ally; Zhang, Chunsheng; Martinez, Sarah Bollinger; Chandramohan, Arun; Lim, U-Ming; Ho, Samantha Shu Wen; Chang, Shih Chieh; Gopal, Pooja; Hong, Lewis Z; Schwaid, Adam; Fernandis, Aaron Zefrin; Loboda, Andrey; Li, Cai; Phan, Uyen; Henry, Brian; Partridge, Anthony W.

Sci Rep; 12(1): 14087, 2022 08 18.

Artículo en Inglés | MEDLINE | ID: mdl-35982220

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