Asunto(s)
Agammaglobulinemia/diagnóstico , Síndromes de Inmunodeficiencia/diagnóstico , Adulto , Agammaglobulinemia/sangre , Agammaglobulinemia/inmunología , Agammaglobulinemia/terapia , Biomarcadores , Niño , Femenino , Seronegatividad para VIH , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina A/inmunología , Inmunoglobulina G/sangre , Inmunoglobulina G/inmunología , Inmunoglobulinas/sangre , Inmunoglobulinas/inmunología , Inmunoglobulinas Intravenosas/uso terapéutico , Síndromes de Inmunodeficiencia/sangre , Síndromes de Inmunodeficiencia/inmunología , Síndromes de Inmunodeficiencia/terapia , Recuento de Linfocitos , Masculino , Resultado del TratamientoAsunto(s)
Inmunidad Humoral , Síndromes de Inmunodeficiencia/inmunología , Infecciones del Sistema Respiratorio/inmunología , Síndrome de Rubinstein-Taybi/inmunología , Niño , Femenino , Humanos , Inmunoglobulinas Intravenosas/administración & dosificación , Síndromes de Inmunodeficiencia/diagnóstico , Factores Inmunológicos/administración & dosificación , Pruebas Inmunológicas , Valor Predictivo de las Pruebas , Recurrencia , Infecciones del Sistema Respiratorio/diagnóstico , Infecciones del Sistema Respiratorio/tratamiento farmacológico , Síndrome de Rubinstein-Taybi/diagnóstico , Resultado del TratamientoAsunto(s)
Granuloma/patología , Trastornos Necrobióticos/patología , Síndrome de Nijmegen/patología , Niño , Femenino , Granuloma/tratamiento farmacológico , Granuloma/inmunología , Granuloma/microbiología , Humanos , Trastornos Necrobióticos/tratamiento farmacológico , Trastornos Necrobióticos/inmunología , Trastornos Necrobióticos/microbiología , Síndrome de Nijmegen/diagnóstico , Síndrome de Nijmegen/genética , Síndrome de Nijmegen/inmunología , Piel/inmunología , Piel/microbiología , Piel/patologíaRESUMEN
We retrospectively analyzed the outcome of hematopoietic stem cell transplantations (HSCT) performed at our Center between 1991 and 2002 in 11 unselected patients with Omenn syndrome, a variant of severe combined immunodeficiency. The patients' mean age at the time of the first HSCT was 8.4 months. Two patients received two, and one patient three, HSCT procedures. The resulting 15 HSCT derived in seven cases from HLA-haploidentical parents, in four patients from matched unrelated donors, in three cases from an HLA phenotypically identical related donor, and in one case from an HLA genotypically identical family donor. Nine out of 11 patients are alive and immunoreconstituted 30-146 months after transplantation. At the time of the most recent evaluation, all of the nine survivors had normal T-cell function, and eight of them had developed normal antibody production. This study demonstrates an overall mortality of 18.2%, which is substantially lower than previously reported. Early recognition of OS, rapid initiation of adequate supportive treatment and HSCT lead to improved outcome for this otherwise fatal disease, regardless of the origin and matching of hematopoietic stem cells.
Asunto(s)
Trasplante de Células Madre Hematopoyéticas , Sarcoma Histiocítico/terapia , Adulto , Anciano , Preescolar , Supervivencia sin Enfermedad , Sarcoma Histiocítico/metabolismo , Sarcoma Histiocítico/mortalidad , Prueba de Histocompatibilidad , Humanos , Masculino , Persona de Mediana Edad , Recuperación de la Función , Estudios Retrospectivos , Síndrome , Linfocitos T/metabolismo , Trasplante Homólogo , Resultado del TratamientoRESUMEN
We evaluated the T-cell repertoire and the thymic output in two infants, one with Omenn Syndrome (OS) and another with complete DiGeorge Syndrome (DGS), who developed generalized dermatitis. The patients shared common T-cell abnormalities, as demonstrated by the low response to mitogenic stimulation, by an unusual usage of specific T-cell receptor (TCR) segments, and by a reduction of TCR diversity in both alpha/beta and gamma/delta populations. Furthermore, they both showed an impaired thymic function, as assessed by the low number of TCR recombination excision circles, which are formed from excised DNA during the rearrangement of TCR genes. These data indicated that generalized erythrodermia may be present in different forms of T-cell immunodeficiency and may reflect intrinsic defects in either V(D)J recombination or in thymic development, leading to the peripheral expansion of T-cell clonotypes, that bear peculiar TCR chains.
Asunto(s)
Inmunodeficiencia Variable Común/complicaciones , Inmunodeficiencia Variable Común/inmunología , Dermatitis/etiología , Síndrome de DiGeorge/complicaciones , Síndrome de DiGeorge/inmunología , Linfocitos T/patología , Timo/fisiopatología , Inmunodeficiencia Variable Común/congénito , Inmunodeficiencia Variable Común/fisiopatología , Síndrome de DiGeorge/congénito , Síndrome de DiGeorge/fisiopatología , Femenino , Amplificación de Genes , Reordenamiento Génico de Linfocito T , Humanos , Lactante , Recién Nacido , Masculino , Receptores de Antígenos de Linfocitos T/genética , Receptores de Antígenos de Linfocitos T/inmunologíaRESUMEN
The use of conventional amphotericin B is limited by toxicity, side-effects, drug interactions and the need for large infusion volumes, especially for infants. Use of liposomal amphotericin B (AmBisome) in 15 paediatric BMT patients with primary immunodeficiency (PID) was therefore studied. Adverse clinical reactions to AmBisome and biochemical profiles were monitored daily for 2 weeks before, during and after each treatment episode. Fungal cultures were obtained weekly and when patients were pyrexial. There were 18 treatment episodes. Mean daily dose was 5 mg/kg (2-6 mg/kg). Mean duration of treatment was 25 days (5-90 days). Clinical reactions to AmBisome were observed in one infant who had a pyrexia of 38 degrees C. One of the 15 infants had a significant increase in creatinine level while on concomitant nephrotoxic therapy. Four developed mild hypokalaemia on AmBisome which resolved with increased potassium supplementation. AmBisome was well tolerated and without significant renal or hepatic toxicity in severely ill immunodeficient infants receiving multiple nephrotoxic and hepatotoxic drugs such as cyclosporin, vancomycin and foscarnet.
Asunto(s)
Anfotericina B/administración & dosificación , Antifúngicos/administración & dosificación , Trasplante de Médula Ósea , Síndromes de Inmunodeficiencia/terapia , Anfotericina B/efectos adversos , Antifúngicos/efectos adversos , Preescolar , Creatinina/sangre , Interacciones Farmacológicas , Tolerancia a Medicamentos , Femenino , Humanos , Hipopotasemia/inducido químicamente , Hipopotasemia/tratamiento farmacológico , Lactante , Riñón/efectos de los fármacos , Liposomas , Hígado/efectos de los fármacos , Masculino , Potasio en la Dieta/administración & dosificación , Estudios Retrospectivos , Seguridad , Inmunodeficiencia Combinada Grave/terapiaRESUMEN
We report herein the results of the cross-cultural adaptation and validation into the Serbian language of the parentís version of two health related quality of life instruments. The Childhood Health Assessment Questionnaire (CHAQ) is a disease specific health instrument that measures functional ability in daily living activities in children with juvenile idiopathic arthritis (JIA). The Child Health Questionnaire (CHQ) is a generic health instrument designed to capture the physical and psychosocial well-being of children independently from the underlying disease. The Serbian CHAQ-CHQ were fully validated with 3 forward and 1 backward translations. A total of 139 subjects were enrolled: 79 patients with JIA (30% systemic onset, 28% polyarticular onset, 6% extended oligoarticular subtype, and 36% persistent oligoarticular subtype) and 60 healthy children. The CHAQ clinically discriminated between healthy subjects and JIA patients, with the systemic, polyarticular and extended oligoarticular subtypes having a higher degree of disability, pain, and a lower overall well-being when compared to their healthy peers. Also the CHQ clinically discriminated between healthy subjects and JIA patients, with the systemic onset, polyarticular onset and extended oligoarticular subtypes having a lower physical and psychosocial well-being when compared to their healthy peers. In conclusion the Serbian version of the CHAQ-CHQ is a reliable, and valid tool for the functional, physical and psychosocial assessment of children with JIA.
Asunto(s)
Artritis Juvenil/diagnóstico , Comparación Transcultural , Estado de Salud , Encuestas y Cuestionarios , Adolescente , Niño , Características Culturales , Evaluación de la Discapacidad , Femenino , Humanos , Lenguaje , Masculino , Psicometría , Calidad de Vida , Reproducibilidad de los Resultados , YugoslaviaAsunto(s)
Antibacterianos/uso terapéutico , Enfermedades de los Bovinos/epidemiología , Mycoplasma bovis/aislamiento & purificación , Neumonía por Mycoplasma/veterinaria , Animales , Secuencia de Bases , Bosnia y Herzegovina/epidemiología , Bovinos , Enfermedades de los Bovinos/tratamiento farmacológico , Enfermedades de los Bovinos/mortalidad , Farmacorresistencia Bacteriana , Pulmón/microbiología , Mycoplasma bovis/clasificación , Cavidad Nasal/microbiología , Neumonía por Mycoplasma/tratamiento farmacológico , Neumonía por Mycoplasma/epidemiología , Neumonía por Mycoplasma/mortalidad , Reacción en Cadena de la Polimerasa/métodos , Reacción en Cadena de la Polimerasa/veterinariaRESUMEN
No disponible
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Humanos , Niño , Agammaglobulinemia/complicaciones , Agammaglobulinemia/diagnóstico , Síndrome de Nijmegen/complicaciones , Síndrome de Nijmegen/diagnóstico , Inmunodeficiencia Variable Común/complicaciones , Inmunodeficiencia Variable Común/diagnóstico , Inmunoglobulinas/inmunología , Pruebas Inmunológicas/métodosRESUMEN
Analysis of pediatric deaths associated with pandemic A H1N1 influenza shows that fatal outcome is more likely in young children, under the age of 5. Neonates, because of the immaturity of their immune system, could represent a high-risk group for severe disease and fatal outcome. We present a group of five neonates with confirmed novel influenza A H1N1 infection. This report indicates that the full spectrum of influenza A H1N1 infection ranging from mild febrile illness with spontaneous recovery to severe disease with fatal outcome may be expected even in neonates.
Asunto(s)
Enfermedades del Prematuro/mortalidad , Subtipo H1N1 del Virus de la Influenza A , Gripe Humana/mortalidad , Pandemias , Antivirales/administración & dosificación , Diagnóstico Diferencial , Resultado Fatal , Femenino , Humanos , Lactante , Recién Nacido , Enfermedades del Prematuro/diagnóstico , Enfermedades del Prematuro/tratamiento farmacológico , Subtipo H1N1 del Virus de la Influenza A/aislamiento & purificación , Gripe Humana/diagnóstico , Gripe Humana/tratamiento farmacológico , Masculino , Oseltamivir/administración & dosificación , Pronóstico , Insuficiencia Respiratoria/diagnóstico , Insuficiencia Respiratoria/tratamiento farmacológico , Insuficiencia Respiratoria/mortalidad , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Factores de RiesgoAsunto(s)
Antifúngicos/administración & dosificación , Aspergilosis/tratamiento farmacológico , Interferón gamma/administración & dosificación , Itraconazol/administración & dosificación , Osteomielitis/tratamiento farmacológico , Niño , Quimioterapia Combinada , Enfermedad Granulomatosa Crónica/complicaciones , Humanos , Masculino , Proteínas RecombinantesRESUMEN
No disponible
Asunto(s)
Humanos , Masculino , Adulto Joven , Síndrome de Nijmegen/tratamiento farmacológico , Budesonida/uso terapéutico , Trastornos por Deficiencias en la Reparación del ADN/diagnóstico , Síndromes de Inmunodeficiencia/diagnóstico , Infecciones del Sistema Respiratorio/etiologíaRESUMEN
UNLABELLED: A patient with Wiskott-Aldrich syndrome who developed Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is described in this study. At 4 mo of age the patient developed fever associated with bicytopenia and splenomegaly. Analysis of a bone marrow specimen revealed extensive haemophagocytosis, and in situ hybridization for EBV of the bone marrow specimen using an EBV-encoded RNA probe was positive. Diagnosis of EBV-HLH was established and immunotherapy with HLH-94 protocol was started. HLH has been described in patients with other well-defined primary immunodeficiencies such as X-linked lymphoproliferative syndrome, Chediak-Higashi syndrome and Griscelli disease. Also, HLH was reported recently in severe combined immunodeficiency and DiGeorge syndrome. CONCLUSION: The possibility of an underlying primary immunodeficiency should be considered in paediatric patients who present with HLH during infancy.
Asunto(s)
Infecciones por Virus de Epstein-Barr/virología , Histiocitosis de Células no Langerhans/complicaciones , Histiocitosis de Células no Langerhans/virología , Síndrome de Wiskott-Aldrich/complicaciones , Preescolar , Infecciones por Virus de Epstein-Barr/tratamiento farmacológico , Infecciones por Virus de Epstein-Barr/inmunología , Hepatomegalia/complicaciones , Humanos , Inmunoglobulina A/inmunología , Inmunoglobulina G/inmunología , Inmunoglobulina M/inmunología , Inmunoglobulinas Intravenosas/uso terapéutico , Masculino , Esplenomegalia/complicacionesRESUMEN
Stivens-Johnson Syndrome is a rare, severe, bullose form of erythema multiforme of unknown etiology. The role of immunological factors in its pathogenesis elucidates. A patients (Sh.V.), nine years of age, was admitted for reccurent streptococcal infections with skin and mucose membrane lesions. In June 1990 streptococcal pharyngitis, fever (38.8-39,9 degrees C) were registered. Penicillin was given. Next day bullous lesions on lips, left ear, trunk and lower extremities and vesiculose lesions with a wide, erythematose base ("iris") and then conjuctivitis were registered. Laboratory tests: SR70.; Leu - 11,0; anti-herpes Ab IgG 1/64, IgM 1/8. Stevens-Johnson was diagnosed. There was a recidivation two years after - oral lesions followed by necrosis and bleeding, after half a year a second recidivation with spreading of bullous and vesiculous lesions to penis gland with prepuce of the penis. Last recidivation in February 1993. Anamnesis: Viral meningitis in 1988. mother suffers from herpes labialis. Peripheral blood immunophenotiping lymphocite extremly indicated decreasing values of B Ly, NK and IL-2R+ cells. Bacteriological tests showed an increase of anti-Chlamidia Ab titer (IgG 1/128, IgA and IgM +). In virological testing there was no increase of titer of Abs against viral antigens (Herpes simplex virus, Varicella-Zoster virus, Citomegalovirus, Adenovirus). We conclude that Stevens-Johnson Sy to be diagnosed by characteristic clinical features, aspecialy by frequent reccurences. Immunological testing during the last recidivation showed that parameters of humoral immune reactivity were within normal ranges while revealed defects of cellular immune reactivity cannot elucidate the ethiopathogenesis of this disease.
Asunto(s)
Síndrome de Stevens-Johnson/diagnóstico , Niño , Humanos , MasculinoRESUMEN
UNLABELLED: We report on a 10-y-old boy who developed Pneumocystis carinii pneumonitis (PCP) as the dominant symptom at the onset of haemophagocytic lymphohistiocytosis (HLH). PCP is a common infection in patients with combined primary immunodeficiencies or acquired immunodeficiency syndrome but it has rarely been observed at the onset of HLH. Typically, HLH presents as a febrile syndrome associated with cytopenia and hepatosplenomegaly. Repeated bone marrow aspirates, spleen or lymph node biopsies are sometimes required to reveal haemophagocytosis. Because of the significant immunosuppression during treatment of HLH, prophylaxis of PCP with co-trimoxazole is recommended. However, de-arranged immune response in HLH renders the patients susceptible to opportunistic infections, even before the introduction of immunosuppressants. CONCLUSION: We suggest that in patients with unclear respiratory symptoms, it is worth considering a differential diagnosis of HLH.